New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp. ZS03 [0.03%]
一株Arthrinium孢子分离菌的抗菌新倍半萜内酯类化合物研究
Songfeng Zhao,Ziwei Jing
Songfeng Zhao
A comprehensive chemical study of the endophytic fungus Arthrinium sp. ZS03, associated with Acorus tatarinowii Schott, yielded eleven pimarane diterpenoids (compounds 1-11), including seven novel compounds designated arthrinoids A-G (1-7)....
Nuciferine alleviates collagen-induced arthritic in rats by inhibiting the proliferation and invasion of human arthritis-derived fibroblast-like synoviocytes and rectifying Th17/Treg imbalance [0.03%]
番红花石竹素通过抑制滑膜成纤维细胞的增殖和侵袭及纠正Th17/Treg失衡来缓解II型胶原诱导的大鼠关节炎作用研究
Hao Wang,Xiaolong Geng,Fangbin Ai et al.
Hao Wang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder marked by persistent synovial inflammation and joint degradation, posing challenges in the development of effective treatments. Nuciferine, an alkaloid found in lotus leaf, has show...
Notoginsenoside Ft1 inhibits colorectal cancer growth by increasing CD8+ T cell proportion in tumor-bearing mice through the USP9X signaling pathway [0.03%]
诺可金通过调节去泛素酶USP9X抑制结直肠癌增殖并增加肿瘤组织中CD8+T细胞比例
Yutao Feng,Yuan Li,Fen Ma et al.
Yutao Feng et al.
The management of colorectal cancer (CRC) poses a significant challenge, necessitating the development of innovative and effective therapeutics. Our research has shown that notoginsenoside Ft1 (Ng-Ft1), a small molecule, markedly inhibits s...
Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway [0.03%]
迪加塞雷因通过抑制DCLK1/STAT3信号通路来抑制结直肠癌生长中的再利用作用研究
Qiaobei Ye,Yu Zhu,Meng Shi et al.
Qiaobei Ye et al.
Double cortin-like kinase 1 (DCLK1) exhibits high expression levels across various cancers, notably in human colorectal cancer (CRC). Diacerein, a clinically approved interleukin (IL)-1β inhibitor for osteoarthritis treatment, was evaluate...
Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγ activation [0.03%]
奥罗苷通过激活PPARγ抑制内质网应激从而防治葡聚糖硫酸钠诱导的结肠炎
Lei Tao,Renjie Dou,Xueming Chen et al.
Lei Tao et al.
Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), may result from immune system dysfunction, leading to the sustained overproduction of reactive oxygen species (ROS) and subsequent cellular oxidative stress dama...
Icariin attenuates vascular endothelial dysfunction by inhibiting inflammation through GPER/Sirt1/HMGB1 signaling pathway in type 1 diabetic rats [0.03%]
淫羊藿黄酮通过GPR30/长寿蛋白sirtuin 1/高迁移率族蛋白B1信号通路抑制炎症改善1型糖尿病大鼠血管内皮细胞功能损伤
Wenhui Yao,Rongpin Tao,Kai Wang et al.
Wenhui Yao et al.
Icariin, a flavonoid glycoside, is extracted from Epimedium. This study aimed to investigate the vascular protective effects of icariin in type 1 diabetic rats by inhibiting high-mobility group box 1 (HMGB1)-related inflammation and explori...
Identification of missing CYP450 enzymes involved in paclitaxel biosynthesis and heterologous reconstitution of baccatin III [0.03%]
鉴定参与紫杉醇生物合成的缺失的细胞色素P450酶并实现巴卡亭Ⅲ的人工异源重构
Jinfa DU,Pan Liao,Xu Lu
Jinfa DU
Tingting Yan,Liangliang Nie,Haiping Hao
Tingting Yan
Isolation and microbial transformation of tea sapogenin from seed pomace of Camellia oleifera with anti-inflammatory effects [0.03%]
一种茶皂素的分离及其抗炎活性微生物转化研究
Pingping Shen,Xuewa Jiang,Jingling Zhang et al.
Pingping Shen et al.
In the current study, tea saponin, identified as the primary bioactive constituent in seed pomace of Camellia oleifera Abel., was meticulously extracted and hydrolyzed to yield five known sapogenins: 16-O-tiglogycamelliagnin B (a), camellia...
Hyparillums A and B: polycyclic polyprenylated acylphloroglucinols from Hypericum patulum [0.03%]
穿心莲中两类新的多环茋化合物 Hyparillums A 和 B
Yulin Duan,Zhengyi Shi,Fei Song et al.
Yulin Duan et al.
Hyparillums A (1) and B (2), two previously unidentified polycyclic polyprenylated acylphloroglucinols (PPAPs) with intricate architectures, were isolated from Hypericum patulum Thunb. Hyparillum A was the first PPAP with eight-carbon rings...