Dammarane-type triterpenoids from Gynostemma longipes and their protective activities on hypoxia-induced injury in PC12 cells [0.03%]
具绞股蓝烷结构的五味子三萜及其对PC12细胞缺氧损伤的保护作用
Haizhen Liang,Xiaojuan Chen,Qi Li et al.
Haizhen Liang et al.
Sixteen new dammarane-type triterpenoid saponins (1-16) featuring diverse structural variations in the side chain at C-17, along with twenty-one known analogues (17-37), have been isolated from the rhizomes of Gynostemma longipes C. Y. Wu, ...
Design, synthesis, and biological evaluation of novel chrysin derivatives as poly(ADP-ribose) polymerase 1 (PARP1) inhibitors for the treatment of breast cancer [0.03%]
新型查尔kins衍生物的设计、合成及生物学评价作为聚（腺苷二磷酸核糖）多聚酶1（PARP1）抑制剂用于乳腺癌治疗
Yao Yang,Jing Tong,Xianshun Xie et al.
Yao Yang et al.
In this study, we reported the discovery and structure-activity relationship analysis of chrysin derivatives as a new class of inhibitors targeting poly (ADP-ribose) polymerase 1 (PARP1). Among these derivatives, compound 5d emerged as the ...
Novel phenanthrene/bibenzyl trimers from the tubers of Bletilla striata attenuate neuroinflammation via inhibition of NF-κB signaling pathway [0.03%]
春石斛兰块茎中三种茋/双苯乙烯三聚体对NF-κB信号通路的抑制作用及抗神经炎症活性研究
Siyuan Shao,Mohan Sun,Xianjie Ma et al.
Siyuan Shao et al.
Five novel (9,10-dihydro) phenanthrene and bibenzyl trimers, as well as two previously identified biphenanthrenes and bibenzyls, were isolated from the tubers of Bletilla striata. Their structures were elucidated through comprehensive analy...
Shengmaisan combined with Liuwei Dihuang Decoction alleviates chronic intermittent hypoxia-induced cognitive impairment by activating the EPO/EPOR/JAK2 signaling pathway [0.03%]
圣玛散联合六味地黄汤通过激活EPO/EPOR/JAK2信号通路缓解慢性间歇性缺氧致认知障碍的作用研究
Jianchao Si,Xue Chen,Kerong Qi et al.
Jianchao Si et al.
Chronic intermittent hypoxia (CIH), a principal pathophysiological aspect of obstructive sleep apnea (OSA), is associated with cognitive deficits. Clinical evidence suggests that a combination of Shengmaisan and Liuwei Dihuang Decoctions (S...
Kun Ma,Mengnan Li,Yahui Song et al.
Kun Ma et al.
Bazi Bushen (BZBS), a traditional Chinese medicine (TCM), has demonstrated therapeutic efficacy in testicular dysfunction within D-galactose and NaNO2 mouse models. This study aimed to ascertain if BZBS could also mitigate the decline in te...
Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction [0.03%]
芍药总苷通过阻断STING-IRF3相互作用缓解cGAS-STING介导的疾病
Ye Xiu,Sihao Wang,Ping Zhang et al.
Ye Xiu et al.
In the realm of autoimmune and inflammatory diseases, the cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) signaling pathway has been thoroughly investigated and established. Despite this, the clinical approval of drugs...
Hernandezine promotes cancer cell apoptosis and disrupts the lysosomal acidic environment and cathepsin D maturation [0.03%]
Hernándezine促进癌细胞凋亡并扰乱溶酶体酸性环境和cathepsin D成熟
Qianwen Feng,Lu Sun,Muhammad Jibran Sualeh et al.
Qianwen Feng et al.
Hernandezine (Her), a bisbenzylisoquinoline alkaloid extracted from Thalictrum flavum, is recognized for its range of biological activities inherent to this herbal medicine. Despite its notable properties, the anti-cancer effects of Her hav...
Potential role of the protein interactome in translating TCM theory and clinical practice into modern biomedical knowledge [0.03%]
蛋白质相互作用组在将中医理论和临床实践转化为现代生物医学知识中的潜在作用
Qian Chen,Xiaohui Fan
Qian Chen
Rapid characterization of non-volatile phenolic compounds reveals the reliable chemical markers for authentication of traditional Chinese medicine Xiang-ru among confusing Elsholtzia species [0.03%]
快速表征非挥发性酚类化合物揭示了香薷防伪认证的可靠化学标志物用于复杂的益母草属物种中
Zhen Zeng,Chen Zhang,Jiadong Hu et al.
Zhen Zeng et al.
The aerial parts of Mosla chinensis Maxim. and Mosla chinensis cv. 'Jiangxiangru' (MCJ) are widely utilized in traditional Chinese medicine (TCM), known collectively as Xiang-ru. However, due to clinical effectiveness concerns and frequent ...
Xiaolei Huang,Xusheng Huang,Qirun Li et al.
Xiaolei Huang et al.
Phorbol esters are recognized for their dual role as anti-HIV-1 agents and as activators of protein kinase C (PKC). The efficacy of phorbol esters in binding with PKC is attributed to the presence of oxygen groups at positions C20, C3/C4, a...