Natural products from untapped sources as a potent reserve against antimicrobial resistance crisis [0.03%]
未利用资源中的天然产物可作为对抗抗菌素抗药性危机的有效储备库
Xiaoxia Gu,Weiguang Sun,Zhengxi Hu
Xiaoxia Gu
Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica [0.03%]
Vernonia sylvatica中抗炎倍半萜内酯类化合物的研究
Min Wang,Han Li,Bintao Hu et al.
Min Wang et al.
Nine new germacranolides, sylvaticalides A-H (1-9), and three known analogues (10-12) were isolated from the aerial part of Vernonia sylvatica. Their structures were established using comprehensive spectroscopic analysis, including high-res...
Palmitic acid reduces the methylation of the FOXO1 promoter to suppress the development of diffuse large B-cell lymphoma via modulating the miR-429/DNMT3A axis [0.03%]
棕榈酸通过调节miR-429/DNMT3A轴降低FOXO1启动子甲基化来抑制弥漫性大B细胞淋巴瘤的发生发展
Weiming Li,Ming Gao,Weili Xue et al.
Weiming Li et al.
Diffuse large B-cell lymphoma (DLBCL) is characterized by significant treatment resistance. Palmitic acid (PA) has shown promising antitumor properties. This study aims to elucidate the molecular mechanisms by which PA influences DLBCL prog...
Si-Miao-Yong-An Decoction alleviates thromboangiitis obliterans by regulating miR-548j-5p/IL-17A signaling pathway [0.03%]
四妙勇安汤通过调节miR-548j-5p/IL-17A信号通路治疗血栓闭塞性脉管炎
Chu Chu,Shangwen Sun,Zhen Zhang et al.
Chu Chu et al.
Thromboangiitis obliterans (TAO) is a rare, chronic, progressive, and segmental inflammatory disease characterized by a high rate of amputation, significantly compromising the quality of life of patients. Si-Miao-Yong-An decoction (SMYA), a...
Exposure to ephedrine attenuates Th1/Th2 imbalance underlying OVA-induced asthma through airway epithelial cell-derived exosomal lnc-TRPM2-AS [0.03%]
麻黄碱通过气道上皮细胞分泌的长链非编码RNA lnc-TRPM2-AS介导的外泌体缓解卵清蛋白诱导的小鼠哮喘中Th1/Th2失衡作用机制研究
Yan Hu,Mengqing Wang,Jing Xie et al.
Yan Hu et al.
Although various anti-inflammatory medications, such as ephedrine, are employed to manage cough-variant asthma, their underlying mechanisms are yet to be fully understood. Recent studies suggest that exosomes derived from airway epithelial ...
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy [0.03%]
芍药苷通过促进线粒体自噬抑制NLRP3炎性小体活化从而缓解抑郁效应
Lili Su,Pengli Guo,Xiangjuan Guo et al.
Lili Su et al.
Depression ranks among the most common neuropsychiatric disorders globally. Current studies examining the roles of inflammation and mitochondrial autophagy in the antidepressant efficacy of paeoniflorin (PF) are sparse. This study aimed to ...
Fu-Zheng-Yi-Liu Formula inhibits the stem cells and metastasis of prostate cancer via tumor-associated macrophages/C-C motif chemokine ligand 5 pathway in tumor microenvironment [0.03%]
扶正益气方通过肿瘤微环境中的肿瘤相关巨噬细胞/CCL5信号通路抑制前列腺癌干细胞及其转移
Chiwei Chen,Renlun Huang,Neng Wang et al.
Chiwei Chen et al.
Prostate cancer (PCa) is the second most common malignancy among men globally. The Fu-Zheng-Yi-Liu (FZYL) Formula has been widely utilized in the treatment of PCa. This study investigates whether the FZYL Formula can inhibit PCa by targetin...
Reynosin protects neuronal cells from microglial neuroinflammation by suppressing NLRP3 inflammasome activation mediated by NADPH oxidase [0.03%]
赖诺普利通过抑制NADPH氧化酶介导的NLRP3炎性小体活化来保护神经元细胞免受小胶质细胞神经炎症的损害
Yanqiu Yang,Yue Che,Mingxia Fang et al.
Yanqiu Yang et al.
Neuroinflammation, mediated by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing-3 (NLRP3) inflammasome, is a significant contributor to the pathogenesis of neurodegenerative diseases (NDDs). Reynosi...