Activation of LONP1 by 84-B10 alleviates aristolochic acid nephropathy via re-establishing mitochondrial and peroxisomal homeostasis [0.03%]
84-B10通过激活LONP1缓解马兜铃酸肾病并恢复线粒体和过氧化物酶体的稳态
Xinyue Xu,Wenping Zhu,Mengqiu Miao et al.
Xinyue Xu et al.
Pharmaceutical formulations derived from Aristolochiaceae herbs, which contain aristolochic acids (AAs), are widely used for medicinal purposes. However, exposure to these plants and isolated AAs is linked to renal toxicity, known as AA nep...
Discovery and characterization of naturally occurring covalent inhibitors of SARS-CoV-2 Mpro from the antiviral herb Ephedra [0.03%]
从抗病毒草药麻黄中发现和表征针对SARS-CoV-2 Mpro的天然共价抑制剂
Qing Hu,Yiwen Zhang,Pengcheng Chen et al.
Qing Hu et al.
The Chinese herb Ephedra (also known as Mahuang) has been extensively utilized for the prevention and treatment of coronavirus-induced diseases, including coronavirus disease 2019 (COVID-19). However, the specific anti-SARS-CoV-2 compounds ...
Natural medicine can substitute antibiotics in animal husbandry: protective effects and mechanisms of rosewood essential oil against Salmonella infection [0.03%]
天然香料紫苏叶油替代抗生素防治副溶血性弧菌感染的研究及其作用机制
Lanqiao Wang,Juan Fang,Heng Wang et al.
Lanqiao Wang et al.
Aniba rosaeodora essential oil (RO) has been traditionally used in natural medicine as a substitute for antibiotics due to its notable antidepressant and antibacterial properties. Salmonella, a prevalent pathogen in foodborne illnesses, pre...
Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis [0.03%]
熟地黄提取物通过恢复细胞内铁稳态来改善肝脏缺血再灌注损伤
Yinhao Zhang,Kexin Jia,Yufei Li et al.
Yinhao Zhang et al.
Hepatic ischemia/reperfusion injury (HIRI) is a common pathophysiological condition occurring during or after liver resection and transplantation, leading to hepatic viability impairment and functional deterioration. Recently, ferroptosis, ...
Different processing methods and pharmacological effects of Atractylodis Rhizoma [0.03%]
不同处理方法对白术药理作用的影响研究进展
Dongmei Guo,Kang Xu,Qianyun Wan et al.
Dongmei Guo et al.
Atractylodis Rhizoma, a traditional Chinese medicine with an extensive history of treating gastrointestinal disorders and other diseases, undergoes various processing methods in China to enhance its therapeutic efficacy for specific conditi...
Traditional Chinese medicines derived natural inhibitors of ferroptosis on ischemic stroke [0.03%]
来源于中医药的缺血性卒中铁死亡天然抑制剂
Yongliang Wang,Xiaobing Lan,Ning Liu et al.
Yongliang Wang et al.
Ischemic stroke (IS) is a globally prevalent cerebrovascular disorder resulting from cerebral vessel occlusion, leading to significant morbidity and mortality. The intricate pathological mechanisms underlying IS complicate the development o...
Emerging mechanisms of non-alcoholic steatohepatitis and novel drug therapies [0.03%]
非酒精性脂肪肝病发病机制及药物治疗新策略研究进展
Hao Chen,Yang Zhou,Haiping Hao et al.
Hao Chen et al.
Non-alcoholic fatty liver disease (NAFLD) has become a leading cause of chronic liver disease globally. It initiates with simple steatosis (NAFL) and can progress to the more severe condition of non-alcoholic steatohepatitis (NASH). NASH of...
Taohong Siwu Decoction: a classical Chinese prescription for treatment of orthopedic diseases [0.03%]
桃红四物汤：用于骨科疾病治疗的古典中药方剂
Yunzhen Shi,Shengpeng Wang,Disi Deng et al.
Yunzhen Shi et al.
The pathogenesis of orthopedic diseases is intimately linked to blood stasis, frequently arising from damage to primary and secondary blood channels. This disruption can lead to "blood leaving the meridians" or Qi stagnation, resulting in b...
Approved drugs and natural products at clinical stages for treating Alzheimer's disease [0.03%]
已用于阿尔茨海默病治疗的临床药物和天然产物
Yajing Ma,Sufang Liu,Qingfeng Zhou et al.
Yajing Ma et al.
Alzheimer's disease (AD) remains the foremost cause of dementia and represents a significant unmet healthcare need globally. The complex pathogenesis of AD, characterized by various pathological and physiological events, has historically ch...
The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium: a review [0.03%]
ericiopsis蘑菇属药食两用真菌次级代谢产物的化学结构、生物合成及活性研究综述
Jianzhao Qi,Jing Wu,Shijie Kang et al.
Jianzhao Qi et al.
Fungal phytochemicals derived from higher fungi, particularly those from the culinary-medicinal genus Hericium, have gained significant attention in drug discovery and healthcare. This review aims to provide a comprehensive analysis of the ...