Four new diarylheptanoids and two new terpenoids from the fruits of Alpinia oxyphylla and their anti-inflammatory activities [0.03%]
一果的四个新的茋类和两个倍半萜类化合物及其抗炎活性研究
Jie Dong,Haibo Li,Mi Zhou et al.
Jie Dong et al.
Four previously unreported diarylheptanoids (1a/1b-2a/2b), one undescribed sesquiterpenoid (8), one new diterpenoid (12), and twelve known analogs were isolated from the fruits of Alpinia oxyphylla. The structural elucidation of these compo...
Targeting TLR4 and regulating the Keap1/Nrf2 pathway with andrographolide to suppress inflammation and ferroptosis in LPS-induced acute lung injury [0.03%]
andrographolide靶向TLR4并调节Keap1/Nrf2途径以抑制LPS诱导的急性肺损伤中的炎症和铁死亡
Yichen Li,Liting Huang,Jilang Li et al.
Yichen Li et al.
Acute lung injury (ALI) is a severe inflammatory condition with a high mortality rate, often precipitated by sepsis. The pathophysiology of ALI involves complex mechanisms, including inflammation, oxidative stress, and ferroptosis, a novel ...
Advances in intelligent mass spectrometry data processing technology for in vivo analysis of natural medicines [0.03%]
用于天然药物体内分析的智能质谱数据处理技术研究进展
Simian Chen,Binxin Dai,Dandan Zhang et al.
Simian Chen et al.
Natural medicines (NMs) are crucial for treating human diseases. Efficiently characterizing their bioactive components in vivo has been a key focus and challenge in NM research. High-performance liquid chromatography-high-resolution mass sp...
Shuwei Li,Qingyi Xiong,Yiwen Shen et al.
Shuwei Li et al.
Toosendanin (TSN), a tetracyclic triterpenoid derived from Melia toosendan and M. azedarach, demonstrates broad application prospects in cancer treatment. Although previously employed as a pesticide, recent studies have revealed its potenti...
New insight into targeting the DNA damage response in the treatment of glioblastoma [0.03%]
针对胶质母细胞瘤治疗中靶向DNA损伤反应的新见解
Tengfei Zhen,Tianyu Sun,Baichen Xiong et al.
Tengfei Zhen et al.
Glioblastoma (GBM) is the most common invasive malignant tumor in human brain tumors, representing the most severe grade of gliomas. Despite existing therapeutic approaches, patient prognosis remains dismal, necessitating the exploration of...
Glasesterterpenoids A-C: three sesterterpenoids with 7-cyclohexyldecahydronaphthalene carbon skeleton isolated from the root of Lindera glauca [0.03%]
绿萼叶冬青根中具有环己基癸氢萘碳架的三个倍半萜类化合物
Shiting He,Qinghui Zou,Qi Zhang et al.
Shiting He et al.
Three novel sesterterpenoids glasesterterpenoids A-C (1-3), featuring an unprecedented 7-cyclohexyldecahydronaphthalene carbon skeleton, were isolated from the root of Lindera glauca (L. glauca). Their structures were elucidated by quantum ...
Macrocyclic trichothecenes from Myrothecium verrucaria PA 57 and their cytotoxic activity [0.03%]
Myrothecium verrucaria PA 57 的大环三帖类化合物及其细胞毒活性研究
Jisong Mo,Yufen Tan,Wenjing Ai et al.
Jisong Mo et al.
Four novel macrocyclic trichothecenes, termed mytoxins D-G (1-4), along with four known analogs (5-8), were isolated from the ethyl acetate extract of fermented rice inoculated with the fungus Myrothecium verrucaria PA57. Each compound feat...
Discovery of antitumor diterpenoids from Casearia graveolens targeting VEGFR-2 to inhibit angiogenesis [0.03%]
一种作用于VEGFR-2以抑制血管生成的抗肿瘤茋二萜类化合物的发现来自主良藤黄树叶提取物
Sibei Wang,Yuhui Liu,Yue Liang et al.
Sibei Wang et al.
Eight novel clerodane diterpenoids (1-8) were isolated from the twigs of Casearia graveolens. Their structures were elucidated through comprehensive nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry...
Cytotoxic lignans from the roots and rhizomes of Diphylleia sinensis, a China's endemic plant species [0.03%]
中国大陆独有植物粗柱果防己科滇防己干燥根和根茎中的细胞毒双菲类木脂素化合物研究
Yanjun Sun,Chen Zhao,Hongyun Bai et al.
Yanjun Sun et al.
Eight novel arylnaphthalide lactone lignans, designated as diphylignan A-H (1-8), and a new dibenzyltyrolactone lignan, designated as diphylignan I (9), were isolated from the roots and rhizomes of Diphylleia sinensis, along with two additi...
Antibacterial and cytotoxic metabolites produced by Streptomyces tanashiensis BYF-112 isolated from Odontotermes formosanus [0.03%]
来源于Odontotermes formosanus的链霉菌BYF-112的抑菌及细胞毒活性代谢产物研究
Jun Wu,Tao Song,Le Zhang et al.
Jun Wu et al.
Chemical investigations of the termite-associated Streptomyces tanashiensis BYF-112 resulted in the discovery of four novel alkaloid derivatives: vegfrecines A and B (1 and 2), exfoliazone A (3), and venezueline H (7), in addition to nine k...