Exploring the mechanism of Xiaoaiping Injection inhibiting autophagy in prostate cancer based on proteomics [0.03%]
基于蛋白质组学探讨消癌平注射液抑制前列腺癌自噬的机制研究
Qiuping Zhang,Qiuju Huang,Zhiping Cheng et al.
Qiuping Zhang et al.
Xiaoaiping (XAP) Injection demonstrates the anti-prostate cancer (PCa) effects, yet the underlying mechanism remains unclear. This study aims to investigate the impact of XAP on PCa and elucidate its mechanism of action. PCa cell proliferat...
Astragali Radix-Notoginseng Radix et Rhizoma medicine pair prevents cardiac remodeling by improving mitochondrial dynamic balance [0.03%]
黄苠和三七药对通过改善线粒体动态平衡防治心脏重构
Pingping Lin,Hong Chen,Zekun Cui et al.
Pingping Lin et al.
Astragali Radix (AR) and Notoginseng Radix et Rhizoma (NR) are frequently employed in cardiovascular disease treatment. However, the efficacy of the AR-NR medicine pair (AN) in improving cardiac remodeling and its underlying mechanism remai...
Stem-leaf saponins of Panax notoginseng attenuate experimental Parkinson's disease progression in mice by inhibiting microglia-mediated neuroinflammation via P2Y2R/PI3K/AKT/NFκB signaling pathway [0.03%]
三七茎叶总皂苷通过P2Y2受体介导的磷脂酰肌醇3-激酶/蛋白激酶B/核因子κB信号通路抑制小胶质细胞活化而缓解实验性帕金森病大鼠模型疾病进程
Hui Wu,Chenyang Ni,Yu Zhang et al.
Hui Wu et al.
Stem-leaf saponins from Panax notoginseng (SLSP) comprise numerous PPD-type saponins with diverse pharmacological properties; however, their role in Parkinson's disease (PD), characterized by microglia-mediated neuroinflammation, remains un...
Research progress of small-molecule natural medicines for the treatment of ischemic stroke [0.03%]
小分子天然药物治疗缺血性脑卒中的研究进展
Kui Liu,Ling Wang,Tao Pang
Kui Liu
Stroke is the second leading cause of disability and mortality worldwide, imposing a substantial socioeconomic burden on individuals and healthcare systems. Annually, approximately 14 million people experience stroke, with ischemic stroke c...
Curvularin derivatives from hydrothermal vent sediment fungus Penicillium sp. HL-50 guided by molecular networking and their anti-inflammatory activity [0.03%]
基于分子网络引导的热液喷口真菌Penicillium sp. HL-50中curvularin衍生物的分离及其抗炎活性研究
Chunxue Yu,Zixuan Xia,Zhipeng Xu et al.
Chunxue Yu et al.
Guided by molecular networking, nine novel curvularin derivatives (1-9) and 16 known analogs (10-25) were isolated from the hydrothermal vent sediment fungus Penicillium sp. HL-50. Notably, compounds 5-7 represented a hybrid of curvularin a...
Amoenucles A-F, novel nucleoside derivatives with TNF-α inhibitory activities from Aspergillus amoenus TJ507 [0.03%]
来自Aspergillus amoenus TJ507的阿莫纽克素A-F：具有抑制TNF-α活性的新核苷衍生物
Yeting Zhang,Zhengyi Shi,Chunhua Zhao et al.
Yeting Zhang et al.
Amoenucles A-F (1-6), six previously undescribed nucleoside derivatives, and two known analogs (7 and 8) were isolated from the culture of Aspergillus amoenus TJ507. Their structures were elucidated through spectroscopic analysis, single-cr...
Tianxiangdan (TXD) alleviates myocardial ischemia reperfusion-induced ferroptosis through the activation of estrogen receptor alpha (ERα) [0.03%]
天香丹通过激活雌激素受体α来缓解心肌缺血再灌注诱导的铁死亡
Yuanjia Yue,Yu Li,Xing Rong et al.
Yuanjia Yue et al.
Tianxiangdan (TXD), a traditional Chinese herbal remedy, demonstrates efficacy in mitigating myocardial ischemia-reperfusion (I/R)-induced damage. This study employed network pharmacology to evaluate the therapeutic targets and mechanisms o...
Pinelliae Rhizoma: a systematic review on botany, ethnopharmacology, phytochemistry, preclinical and clinical evidence [0.03%]
半夏的系统性综述：植物、民族药理学、植物化学、非临床及临床证据
Zuanji Liang,Jinchao Wei,Sioi Chan et al.
Zuanji Liang et al.
Pinelliae Rhizoma (PR), known as Banxia in Chinese, Hange in Japanese, and Banha in Korean, is a renowned herbal medicine in East Asia derived from the dry tuber of Pinellia ternata (Thunb.) Breit. (PT). It is extensively utilized in dispen...
Traditional Chinese medicine-based drug delivery systems for anti-tumor therapies [0.03%]
基于中医药的抗肿瘤治疗递药系统研究进展
Ling Yang,Yani Wang,Xietao Ye et al.
Ling Yang et al.
The treatment of tumors continues to be significantly challenging. The presence of multiple modalities, including surgery, radiation, chemotherapy and immunotherapy, the therapeutic outcomes remain limited and are often associated with adve...
Natural endogenous material-based vehicles for delivery of macromolecular drugs [0.03%]
基于天然内源性材料的高分子药物递送载体
An Lu,Kang DU,Meng Wang et al.
An Lu et al.
Natural endogenous materials (NEMs), such as cell and cell derivatives, polysaccharide, protein and peptide, and nucleic acid-derived vectors, often exhibit biocompatibility, biodegradability and natural homing ability, which can minimize a...