Protective effect of the extract of Yi-Qi-Fu-Mai preparation on hypoxia-induced heart injury in mice [0.03%]
益气复脉汤对缺氧诱导的小鼠心肌损伤的保护作用研究
Ya-Qian Feng,Ai-Chun Ju,Chun-Hua Liu et al.
Ya-Qian Feng et al.
Yi-Qi-Fu-Mai (YQFM) is extensively used clinically to treat cardiovascular diseases in China. To explore the anti-hypoxia effect of the extract of YQFM preparation (EYQFM), the EYQFM (1.4, 2.8, and 5.5 g·kg(-1)·d(-1)) was assessed for its...
Simultaneous quantification of chlorogenic acid and taurocholic acid in human plasma by LC-MS/MS and its application to a pharmacokinetic study after oral administration of Shuanghua Baihe tablets [0.03%]
一种LC-MS/MS同时测定人血浆中绿原酸和牛磺胆酸的方法及其在双华白合片口服给药后药物动力学研究中的应用
Pan Gu,Rui-Juan Liu,Min-Lu Cheng et al.
Pan Gu et al.
An LC-MS/MS method was developed and validated for the simultaneous quantification of chlorogenic acid (CGA) and taurocholic acid (TCA) in human plasma using hydrochlorothiazide as the internal standard. The chromatographic separation was a...
Chemical constituents of Solanum coagulans and their antimicrobial activities [0.03%]
Solanum coagulans的化学成分及其抗菌活性
Xu-Jie Qin,Paul-Keilah Lunga,Yun-Li Zhao et al.
Xu-Jie Qin et al.
The present study aimed at determining the chemical constituents of Solanum coagulans and their antimicrobial activities. The compounds were isolated by various chromatographic techniques and their structures were elucidated on the basis of...
Leojaponic acids A and B, two new homologous terpenoids, isolated from Leonurus japonicus [0.03%]
来自Leonurus japonicus的两种新的同系类萜化合物Leojaponic酸A和B
Han-Kui Wu,Yan-Jun Mao,Shan-Shan Sun et al.
Han-Kui Wu et al.
The present study aimed at isolation and purification of the bioactive terpenoids from the herb of Leonurus japonicus by chromatographic separations such as silica gel, sephadex LH-20 and C18 reversed phase silica gel, as well as preparativ...
H1-A, a compound isolated from Fusarium oxysporum inhibits hepatitis C virus (HCV) NS3 serine protease [0.03%]
从尖镰孢菌中分离得到的化合物H1-A能够抑制丙型肝炎病毒(NS3丝氨酸蛋白酶)
Li-Yuan Yang,Jun Lin,Bin Zhou et al.
Li-Yuan Yang et al.
The present study was aimed to isolate the active compounds from the fermentation products of Fusarium oxysporum, which had hepatitis C virus (HCV) NS3 protease inhibitory activity. A bioactive compound was isolated by reverse-phase silica-...
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor [0.03%]
中国齿突蟾皮肤毒腺中的两种新型抗菌肽
Hong-Ling Yang,Zhi-Qiang Shen,Xuan Liu et al.
Hong-Ling Yang et al.
Amphibian skin contains rich bioactive peptides. Especially, a large amount of antimicrobial peptides have been identified from amphibian skin secretions. Antimicrobial peptides display potent cytolytic activities against a range of pathoge...
Enhanced production of shikimic acid using a multi-gene co-expression system in Escherichia coli [0.03%]
基于多重基因共表达体系的大肠杆菌莽草酸生产菌株的构建与优化研究
Xiang-Lei Liu,Jun Lin,Hai-Feng Hu et al.
Xiang-Lei Liu et al.
Shikimic acid (SA) is the key synthetic material for the chemical synthesis of Oseltamivir, which is prescribed as the front-line treatment for serious cases of influenza. Multi-gene expression vector can be used for expressing the pluralit...
Appropriate choice of collision-induced dissociation energy for qualitative analysis of notoginsenosides based on liquid chromatography hybrid ion trap time-of-flight mass spectrometry [0.03%]
基于液相色谱-离子陷阱飞行时间质谱的三七皂苷 qualitative 分析中 CID 能量的选择
Guang-Ji Wang,Han-Xu Fu,Jing-Cheng Xiao et al.
Guang-Ji Wang et al.
Liquid chromatography hybrid ion trap/time-of-flight mass spectrometry possessesd both the MS(n) ability of ion trap and the excellent resolution of a time-of-flight, and has been widely used to identify drug metabolites and determine trace...
Protective effects of astragaloside in rats with adriamycin nephropathy and underlying mechanism [0.03%]
黄芪苷对阿霉素肾病大鼠保护作用及机制研究
Na Wang,Ri-Bao Wei,Qing-Ping Li et al.
Na Wang et al.
The present study was designed to determine the mechanism underlying the treatment of nephrotic syndrome using astragaloside by observing the effects of astragaloside on the expression of nephrin and podocin proteins and genes in kidneys of...
Puerarin prevents bone loss in ovariectomized mice and inhibits osteoclast formation in vitro [0.03%]
葛根素通过体外和体内实验证明能预防绝经后妇女骨质疏松发生与发展
Si-Yuan Yuan,Tong Sheng,Lian-Qi Liu et al.
Si-Yuan Yuan et al.
The present study aimed at investigating the effects of Puerarin (PR), a major isoflavonoid isolated from the Chinese medicinal herb Puerariae radix, on bone metabolism and the underlying mechanism of action. The in vivo assay, female mice ...