A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy [0.03%]
一种黄喹啉基白藜芦醇类似物通过促进Parkin介导的线粒体自噬在缺血性中风后改善神经元损伤
Qingqi Meng,Yan Mi,Libin Xu et al.
Qingqi Meng et al.
Ischemic stroke (IS) is a prevalent neurological disorder often resulting in significant disability or mortality. Resveratrol, extracted from Polygonum cuspidatum Sieb. et Zucc. (commonly known as Japanese knotweed), has been recognized for...
Nigella sativa L. seed extract alleviates oxidative stress-induced cellular senescence and dysfunction in melanocytes [0.03%]
黑种草籽提取物减轻黑色素细胞的氧化应激诱导的细胞衰老和功能障碍
Ben Niu,Xiaohong An,Yongmei Chen et al.
Ben Niu et al.
Nigella sativa L. seeds have been traditionally utilized in Chinese folk medicine for centuries to treat vitiligo. This study revealed that the ethanolic extract of Nigella sativa L. (HZC) enhances melanogenesis and mitigates oxidative stre...
Capsaicin (CAP) exerts a protective effect against ethanol-induced oxidative gastric mucosal injury by modulating the chemokine receptor 4 (CCR4)/Src/p47phox signaling pathway both in vitro and in vivo [0.03%]
辣椒素通过调节趋化因子受体4/Src/p47phox信号通路对乙醇诱导的氧化性胃粘膜损伤起到保护作用的体内外研究
Zhiru Yang,Haolin Guo,Pengfei Zhang et al.
Zhiru Yang et al.
Ethanol (EtOH) is a common trigger for gastric mucosal diseases, and mitigating oxidative stress is essential for attenuating gastric mucosal damage. Capsaicin (CAP) has been identified as a potential agent to counteract oxidative damage in...
Metabolomics as an emerging tool for the pharmacological and toxicological studies on Aconitum alkaloids [0.03%]
代谢组学作为对乌头生物碱药理和毒理学研究的一种新兴工具
Han Ding,Yamin Liu,Sifan Wang et al.
Han Ding et al.
Aconitum (Ranunculaceae) has a long-standing history in traditional Chinese medicine (TCM), where it has been widely used to treat conditions such as rheumatoid arthritis (RA), myocardial infarction, and heart failure. However, the potency ...
A comprehensive review on wedelolactone: natural sources, total synthesis, and pharmacological activities [0.03%]
wedelolactone的全面评述：天然来源，全合成及药理活性
Haiping Cai,Yue Wu,Xiaojin Zhang
Haiping Cai
Plant-derived natural products have long been a vital source for developing therapeutic drugs. Wedelolactone (WDL), a coumestan isolated from Eclipta prostrata, Wedelia calendulacea, Wedelia chinensis, and Sphagneticola trilobata, demonstra...
Metabolic insights into gut microbiota in the pharmacology of natural medicines [0.03%]
肠道微生物对天然药物药理学的代谢研究进展
Zixin Chen,Junchi Zhou,Xiao Zheng et al.
Zixin Chen et al.
Natural medicines (NMs) demonstrate distinct advantages in the clinical management of chronic diseases. Recent years have seen growing recognition of the gut microbiota's role in the efficacy and synergy of NMs, providing new impetus for el...
Research progress in methods of acquisition, structure elucidation, and quality control of Chinese herbal polysaccharides [0.03%]
中药多糖的提取、结构表征及质量控制研究进展
Tingting Wang,Baojie Zhu,Jing Zhao et al.
Tingting Wang et al.
The therapeutic efficacy of traditional Chinese medicine has been widely acknowledged due to its extensive history of clinical effectiveness. However, the precise active components underlying each prescription remain incompletely understood...
General expert consensus on the application of network pharmacology in the research and development of new traditional Chinese medicine drugs [0.03%]
网络药理学在新中药研发中应用的通用专家共识
Shao Li,Wei Xiao
Shao Li
The research and development of new traditional Chinese medicine (TCM) drugs have progressively established a novel system founded on the integration of TCM theory, human experience, and clinical trials (termed the "Three Combinations"). Ho...
Buqi-Tongluo Decoction inhibits osteoclastogenesis and alleviates bone loss in ovariectomized rats by attenuating NFATc1, MAPK, NF-κB signaling [0.03%]
补气活血汤通过抑制NFATc1、MAPK和NF-κB信号通路减少卵巢切除大鼠破骨细胞生成及骨丢失
Yongxian Li,Jinbo Yuan,Wei Deng et al.
Yongxian Li et al.
Osteoporosis is a prevalent skeletal condition characterized by reduced bone mass and strength, leading to increased fragility. Buqi-Tongluo (BQTL) decoction, a traditional Chinese medicine (TCM) prescription, has yet to be fully evaluated ...
Zhongfeng Xingnao Liquid ameliorates post-stroke cognitive impairment through sirtuin1 (SIRT1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway [0.03%]
复方醒脑液通过激活SIRT1/Nrf2/HO-1信号通路改善缺血性卒中后认知功能障碍
Wenqin Yang,Wen Wen,Hao Chen et al.
Wenqin Yang et al.
The activation of the sirtuin1 (SIRT1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway has been shown to mitigate oxidative stress-induced apoptosis and mitochondrial damage by reducing reactive oxygen spe...