Denghui Zhu,Jingke Zhang,Pengli Guo et al.
Denghui Zhu et al.
Twelve previously unidentified triterpenoids (1-12) were isolated from the dichloromethane extract of Alisma orientale (A. orientale). Among these compounds, 1 and 2 exhibited a rare 6/6/7/5 tetracyclic ring system, and compound 3 was lanos...
Cytotoxic anthrone-cyclopentenone heterodimers from the fungus Penicillium sp. guided by molecular networking [0.03%]
基于分子网络引导的曲霉属真菌茋类茋倍半萜杂二聚体及其抗肿瘤活性研究
Ruiyun Huo,Jiayu Dong,Gaoran Liu et al.
Ruiyun Huo et al.
(±)-Penicithrones A-D (1a/1b-4a/4b), four novel pairs of anthrone-cyclopentenone heterodimers characterized by a distinctive bridged 6/6/6-5 tetracyclic core skeleton, together with three previously identified compounds (5-7), were isolate...
New diterpenoids from Euphorbia wallichii with antioxidant activity [0.03%]
具抗氧化活性的牻牛儿苗属植物姜花大戟中的二萜类化合物研究
Yali Wang,Juan Chen,Wenshuo Zheng et al.
Yali Wang et al.
Thirteen novel diterpenoids, comprising seven tiglianes (walliglianes G-M, 1-7), four rhamnofolanes (wallinofolanes A-D, 8-11), and two daphnanes (wallaphnanes A and B, 12 and 13), together with two known rhamnofolane diterpenoids (euphorwa...
Bisdemethoxycurcumin suppresses liver fibrosis-associated hepatocellular carcinoma via inhibiting CXCL12-induced macrophage polarization [0.03%]
茋衍生的姜黄素类似物抑制肝纤维化相关肝癌中的CXCL12诱导的巨噬细胞极化作用
Wei Yuan,Xinxin Zeng,Bin Chen et al.
Wei Yuan et al.
Chronic, unresolved inflammation correlates with persistent hepatic injury and fibrosis, ultimately progressing to hepatocellular carcinoma (HCC). Bisdemethoxycurcumin (BDMC) demonstrates therapeutic potential against HCC, yet its mechanism...
(+)-Strebloside induces Non-Hodgkin lymphoma cell death through the STEAP3-Mediated Ferroptosis and MAPK pathway [0.03%]
斯特布洛昔诱导的STEAP3介导的铁死亡和MAPK通路非霍奇金淋巴瘤细胞死亡
Yu Zhao,Jing Cai,Ying Yang et al.
Yu Zhao et al.
(+)-Strebloside, a significant bioactive compound isolated from the roots of Streblus asper Lour., demonstrates inhibitory effects against multiple malignancies. However, its specific function and underlying mechanistic pathways in Non-Hodg...
Chinese agarwood petroleum ether extract suppressed gastric cancer progression via up-regulation of DNA damage-induced G0/G1 phase arrest and HO-1-mediated ferroptosis [0.03%]
沉香石油醚萃取物通过调节DNA损伤诱导的G0/G1期阻滞和HO-1介导的铁死亡抑制胃癌进展
Lishan Ouyang,Xuejiao Wei,Fei Wang et al.
Lishan Ouyang et al.
Gastric cancer (GC) is characterized by high morbidity and mortality rates. Chinese agarwood comprises the resin-containing wood of Aquilaria sinensis (Lour.) Gilg., traditionally utilized for treating asthma, cardiac ischemia, and tumors. ...
Taohe Chengqi decoction inhibits PAD4-mediated neutrophil extracellular traps and mitigates acute lung injury induced by sepsis [0.03%]
陶氏承气汤通过抑制PAD4介导的中性粒细胞胞外陷阱减轻脓毒症诱导的急性肺损伤
Mengting Xie,Xiaoli Jiang,Weihao Jiang et al.
Mengting Xie et al.
Acute lung injury (ALI) is a significant complication of sepsis, characterized by high morbidity, mortality, and poor prognosis. Neutrophils, as critical intrinsic immune cells in the lung, play a fundamental role in the development and pro...
Compatibility of cold herb CP and hot herb AZ in Huanglian Ganjiang decoction alleviates colitis mice through M1/M2 macrophage polarization balance via PDK4-mediated glucose metabolism reprogramming [0.03%]
黄连甘草配伍通过PDK4介导的糖代谢重编程缓解结肠炎小鼠M1/M2巨噬细胞极化平衡Compatibility of cold herb CP and hot herb AZ in Huanglian Ganjiang decoction alleviates colitis mice through M1/M2 macrophage polarization balance via PDK4-mediated glucose metabolism reprogramming
Yanyang Li,Chang Liu,Yi Wang et al.
Yanyang Li et al.
Ulcerative colitis (UC) is a chronic and non-specific inflammatory bowel disease (IBD). Huanglian Ganjiang decoction (HGD), derived from ancient book Beiji Qianjin Yao Fang, has demonstrated efficacy in treating UC patients traditionally. P...
The novel combination of astragaloside IV and formononetin protects from doxorubicin-induced cardiomyopathy by enhancing fatty acid metabolism [0.03%]
新型绞股蓝皂苷IV和金雀异黄素联合用药通过增强脂肪酸代谢保护心脏免受阿霉素损害所致的心肌病伤害
Xinyue Yu,Zhaodi Han,Linling Guo et al.
Xinyue Yu et al.
Astragali Radix (AR), a traditional Chinese medicine (TCM), has demonstrated therapeutic efficacy against various diseases, including cardiovascular conditions, over centuries of use. While doxorubicin serves as an effective chemotherapeuti...
Research progress on new techniques and methods for identifying active ingredients in traditional Chinese medicine [0.03%]
中药活性成分识别的新技术和方法研究进展
Jiaxin Zhang,Xinhao Zhu,Chaofeng Zhang et al.
Jiaxin Zhang et al.
Recent years have witnessed significant advances in the development of novel techniques and methodologies for identifying active ingredients in traditional Chinese medicine (TCM), substantially advancing research and development efforts. Sp...