Evaluation of the antimicrobial and antibiofilm activities of aztreonam-avibactam against the Burkholderia cepacia complex [0.03%]
阿维巴坦他唑巴胺对伯克霍尔德菌复合群的抗菌和抗生物被膜活性的评价
Ozlem Oyardi,Damla Damar Celik,Taylan Turan et al.
Ozlem Oyardi et al.
Beta-lactamase production by Burkholderia cepacia complex (Bcc) leads to beta-lactam resistance and worsens patient prognosis. This study describes the activity of aztreonam, a monobactam, in combination with avibactam, a beta-lactamase inh...
Toward microbiota-friendly design and evaluation of antimicrobial peptides: a mini-review [0.03%]
关于抗菌肽的微生态友好设计和评价的 minireview
Aseel Alrashdan
Aseel Alrashdan
The rise of multidrug-resistant (MDR) bacteria driven by the prolonged use and misuse of conventional antibiotics poses a severe threat to global healthcare systems. To combat this risk, considerable research efforts have focused on the dis...
Antimicrobial, antibiofilm, and virulence gene modulatory effects of supercritical CO₂ extracts of Thymbra spicata against clinical MRSA isolates [0.03%]
百里香辣薄荷超临界二氧化碳提取物对临床分离的耐甲氧西林金黄色葡萄球菌的抗菌、抗生物被膜和调变毒力基因效应研究
Mehmet Çimentepe,Salim Yakut,Akin Yigin et al.
Mehmet Çimentepe et al.
In this study, extracts of Thymbra spicata were obtained using supercritical carbon dioxide (scCO₂) extraction under two different pressure conditions, namely 120 atm (T1) and 300 atm (T2), while maintaining a constant temperature of 40 °...
Network-based bioinformatics for the prediction of candidate SNPs in Staphylococcus aureus virulence and resistance genes [0.03%]
基于网络的生物信息学在金黄色葡萄球菌毒力和耐药基因候选SNP预测中的应用
Agueda Maria De França Tavares,Eliane Macedo Sobrinho Santos,Renata Gabriela Chaves Ferreira et al.
Agueda Maria De França Tavares et al.
This study proposes a network-based bioinformatics strategy to predict candidate genes for SNPs in Staphylococcus aureus that act as points of convergence between antimicrobial resistance and biofilm formation. Based on 19 Staphylococcus au...
Enhanced antibacterial activity of amoxicillin combination with a Cu-Fe sulfide mineral against antimicrobial-resistant bacteria [0.03%]
含铜铁硫化物矿物与氨苄西林联合使用对抗菌耐药菌的增效抗菌活性
Himani Khardiya,Gautam Priyadarshi,Avani Thakkar et al.
Himani Khardiya et al.
Antibiotic resistance (AMR) poses a significant global threat to public health and necessitates the development of new strategies to improve antibiotic efficacy. In the present study, Swarn Makshik (SM) Bhasma (CuFeS2) was synthesised and l...
Immunoinformatics-driven multi-epitope vaccine design as a promising strategy against multidrug-resistant pathogens: a comprehensive review [0.03%]
免疫信息学驱动的多表位疫苗设计作为对抗多重耐药病原体的一种有前途的战略：全面综述
Rameen Nasir,Muhammad Mutayyab Javaid,Raheen Rahman et al.
Rameen Nasir et al.
Infections caused by multidrug-resistant (MDR) pathogens, both gram-negative and gram-positive organisms, have transformed into a silent global pandemic. These pathogens, especially ESKAPE pathogens, exhibit wide resistance patterns to seve...
Stress-induced remodeling of yeast amino acid pools occurs within conserved physicochemical constraints [0.03%]
应激引起的酿酒酵母氨基酸池重建遵循保守的物理化学约束条件
Hajar Ebadi,Payam Setoodeh,Ali Niazi
Hajar Ebadi
Industrial fermentation processes frequently expose yeast cells to environmental fluctuations, particularly temperature stress and oxygen-transfer limitation, which can profoundly alter cellular metabolism and fermentation performance. In t...
Investigation of the effects of ampicillin and ceftazidime on Proteus mirabilis using metabolomic approaches and bioinformatics analyses [0.03%]
采用代谢组学方法和生物信息学分析探讨氨苄西林和头孢他啶对普罗威登菌的效果
Kübra Tekşen,İdil Yet,Ergin Murat Altuner
Kübra Tekşen
Antibiotic resistance is the ability of microorganisms to survive and proliferate despite exposure to antibiotics that would normally inhibit or kill susceptible strains. This resistance can make antibiotics ineffective or diminish their ab...
Exploring halophilic microorganisms for novel antimicrobial discovery: molecular mechanisms and computational approaches [0.03%]
探索嗜盐微生物中新型抗菌物质的发现：分子机制和计算方法
Pooja Bhowmick,Pankaj Kumar,Simran Panjabi et al.
Pooja Bhowmick et al.
The rapid rise in antibiotic resistance, which causes more than 700,000 deaths worldwide each year, has intensified the search for alternative antimicrobial sources to combat multidrug-resistant (MDR) pathogens. Halophilic microorganisms in...
High-level expression and characterization of a thermostable thermolysin-like metalloprotease with industrial potential [0.03%]
一种具有工业应用潜力的耐热枯草芽孢杆菌蛋白酶的高效表达及其性质研究
Sezgin Karaman,Kubilay Metin
Sezgin Karaman
Proteases with high thermostability and catalytic efficiency are highly sought after for industrial applications, particularly within the M4 family of thermolysin-like metalloproteases. In this study, a thermostable thermolysin-like metallo...