Correlation between ROS production and InsP3 released by granulocytes from type 1 diabetic patients in a cAMP-dependent manner [0.03%]
cAMP依赖性产生的ROS与1型糖尿病患者中性粒细胞释放InsP3的相关性研究
Míriam Martins Chaves,Daniela Caldeira Costa,Denniece Adriana da Costa Souza et al.
Míriam Martins Chaves et al.
Background: Diabetes is associated with a pro-inflammatory status characterized by an increased production of inflammatory molecules. Reactive oxygen species (ROS) and cAMP elevating agents represent two molecular systems...
Hypopituitarism in the elderly: multifaceted clinical and biochemical presentation [0.03%]
老年人的垂体功能减退症：多方面的临床和生化表现
L Foppiani,A Ruelle,R Bandelloni et al.
L Foppiani et al.
Hypopituitarism (HYPO) is a rare and under-investigated pathology in the elderly. Aim: to review our case records of patients > or =65 yrs with first diag...
Daniela Galimberti,Chiara Fenoglio,Elio Scarpini
Daniela Galimberti
Inflammation plays a role in the development of Alzheimer's disease (AD). Several cytokines and chemokines have been detected both immunohistochemically and in cerebrospinal fluid from patients. Some of them, including Tumor Necrosis Factor...
Nadezhda D Goncharova,Victor Yu Marenin,Tatiana N Bogatyrenko
Nadezhda D Goncharova
Clinical and experimental data point to existence of disturbances of adaptive ability of aged organism to extreme impacts. However mechanisms of these disturbances are not clear yet. The purpose of the investigation was to study age-related...
Comparative Study
Current aging science. 2008 Mar;1(1):22-9. DOI:10.2174/1874609810801010022 2008
Alberto Sanz,Rhoda K A Stefanatos
Alberto Sanz
The Mitochondrial Free Radical Theory of Aging (MFRTA) proposes that mitochondrial free radicals, produced as by-products during normal metabolism, cause oxidative damage. According to MFRTA, the accumulation of this oxidative damage is the...
Towards an understanding of the anti-aging mechanism of caloric restriction [0.03%]
探究限制卡路里摄入延缓衰老的机制
Gabriella Cavallini,Alessio Donati,Zina Gori et al.
Gabriella Cavallini et al.
Accumulation of oxidatively altered cell components may play a role in the age-related cell deterioration and associated diseases. Caloric restriction is the most robust anti-aging intervention that extends lifespan and retards the appearan...
A new journal with an integrated approach in the study of aging and longevity [0.03%]
一个在衰老和长寿研究中采用综合方法的新期刊
Debomoy K Lahiri
Debomoy K Lahiri
Aamir Ahmad,Sanjeev Banerjee,Zhiwei Wang et al.
Aamir Ahmad et al.
The biochemical phenomenon of aging, as universal as it is, still remains poorly understood. A number of diseases are associated with aging either as a cause or consequence of the aging process. The incidence of human cancers increases expo...