Niloufar Kavian,Amélie Servettaz,Bernard Weill et al.
Niloufar Kavian et al.
The Notch pathway is an evolutionary conserved signalling mechanism that regulates cellular fate and development in various types of cells. The full spectrum of Notch effects has been well studied over the last decade in the fields of devel...
Armando Gabrielli,Silvia Svegliati,Gianluca Moroncini et al.
Armando Gabrielli et al.
Systemic sclerosis (Scleroderma - SSc) is a connective tissue disorder of unknown aetiology characterized by extensive fibrosis of the skin and visceral organs, by vascular abnormalities and immunological manifestations.Recent evidence sugg...
Carol M Artlett
Carol M Artlett
Fibrosis leads to the deposition of collagens in organs and tissues. The resulting pathology induces a loss of function in the organ it is manifested in and this loss of function modulates the morbidity and mortality in that individual. Ind...
New insights into the mechanisms of innate immune receptor signalling in fibrosis [0.03%]
纤维化中先天免疫受体信号传导机制的新见解
Robert Lafyatis,Alessandra Farina
Robert Lafyatis
Recent advances in our understanding of innate immunity and inflammation have direct bearing on how we understand autoimmunity, and fibrosis, and how innate immune sensors might stimulate both of these key features of several fibrotic disea...
Mediators of fibrosis [0.03%]
介导纤维化的分子
Maria Trojanowska
Maria Trojanowska
Laboratory Test Abnormalities are Common in Polymyositis and Dermatomyositis and Differ Among Clinical and Demographic Groups [0.03%]
多发性肌炎和皮肌炎的实验室检查异常很常见，并在不同的临床及人口统计学组中有所差异
Rita Volochayev,Gyorgy Csako,Robert Wesley et al.
Rita Volochayev et al.
Objective: Given the difficulties regarding the interpretation of common laboratory test results in polymyositis (PM) and dermatomyositis (DM) in clinical practice, we assessed their range of abnormalities, differences am...
Pentosidine, an advanced glycation end-product, may reflect clinical and morphological features of hand osteoarthritis [0.03%]
戊糖花青，一种晚期糖基化终产物，可能反映了手骨关节炎的临床和形态学特征
Martin Braun,Hana Hulejová,Jindřiška Gatterová et al.
Martin Braun et al.
The study investigates pentosidine levels, an advanced glycation end-product, in patients with erosive and non-erosive hand osteoarthritis (HOA) and determine its potential association with clinical findings and imaging-defined joint damage...
Renal perfusion in scleroderma patients assessed by microbubble-based contrast-enhanced ultrasound [0.03%]
微气泡增强型对比超声在硬皮病患者肾灌注评估中的应用研究
Stefan Kleinert,Petra Roll,Christian Baumgaertner et al.
Stefan Kleinert et al.
Objectives: Renal damage is common in scleroderma. It can occur acutely or chronically. Renal reserve might already be impaired before it can be detected by laboratory findings. Microbubble-based contrast-enhanced ultraso...
Determinants of Risk Infection During Therapy with Anti TNF-Alpha Blocking Agents in Rheumatoid Arthritis [0.03%]
接受抗TNF-α药物治疗的类风湿关节炎患者的风险感染因素分析
M Benucci,G Saviola,P Baiardi et al.
M Benucci et al.
The use of TNF-alpha antagonists (infliximab, etanercept, adalimumab) has changed the course of many rheumatic diseases including rheumatoid arthritis (RA). Since their approval, some questions regarding their safety including infections ha...
Adverse events in patients with blood loss: a pooled analysis of 51 clinical studies from the celecoxib clinical trial database [0.03%]
来自塞来昔布临床试验数据库中51项临床研究的失血患者不良事件汇总分析
Gh Sands,B Shell,R Zhang
Gh Sands
Background: Chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with an increased risk of gastrointestinal (GI) toxicity, including occult blood loss and the development of clinically significant an...