Delayed Positivization of Cerebral Angiography in Reversible Cerebral Vasoconstriction Syndrome (RCVS) Presenting with Recurrent Subarachnoid Haemorrhage [0.03%]
复发性蛛网膜下腔出血的可逆性脑血管收缩综合征(RCVS)的延迟阳性脑血管造影检查结果分析
Luca Quartuccio,Francesco Tuniz,Benedetto Petralia et al.
Luca Quartuccio et al.
Benign angiopathy of the central nervous system is a clinical syndrome with evidence of reversible cerebral vasoconstriction (RCVS). Haemorrhagic stroke, either subarachnoid or intracerebral is an unusual presentation of RCVS. We describe a...
Sicca Symptoms and their Association with Chronic Rhinosinusitis in a Community Sample [0.03%]
社区样本中的sicca症状及其与慢性鼻窦炎的关系
S Lester,M Rischmueller,Lw Tan et al.
S Lester et al.
Objective: To determine associations between sicca symptoms, chronic rhinosinusitis (CRS) symptoms and asthma in a community survey. Methods: ...
Getting out of a sticky situation: targeting the myofibroblast in scleroderma [0.03%]
破解僵局：系统硬化病中肌成纤维细胞的靶向治疗
Andrew Leask
Andrew Leask
There is no treatment for the fibrosis observed in scleroderma (systemic sclerosis, SSc). Although genome-wide expression profiling has suggested that differences in gene expression patters between non-lesional and lesional skin are minimal...
Sashidhar Nakerakanti,Maria Trojanowska
Sashidhar Nakerakanti
Recent advances in defining TGF-β signaling pathways have provided a new level of understanding of the role of this pleiotropic growth factor in the development of fibrosis. Here, we review selected topics related to the profibrotic role o...
Jessica Trombetta-Esilva,Amy D Bradshaw
Jessica Trombetta-Esilva
Fibrosis is a common end-point of a number of different diseases such as hypertension, diabetes, liver cirrhosis, and those associated with chronic inflammation. Fibrosis is characterized by excessive deposition of extracellular matrix that...
Insulin-like growth factor binding proteins-3 and -5: central mediators of fibrosis and promising new therapeutic targets [0.03%]
胰岛素样生长因子结合蛋白3和5：纤维化核心介体及新的治疗靶点
Kristen L Veraldi,Carol A Feghali-Bostwick
Kristen L Veraldi
Fibrosis involves an orchestrated cascade of events including activation of fibroblasts, increased production and deposition of extracellular matrix components, and differentiation of fibroblasts into myofibroblasts. Epithelial-mesenchymal ...
Serena Vettori,Steffen Gay,Oliver Distler
Serena Vettori
Fibrosis is the leading cause of organ dysfunction in diseases such as systemic sclerosis, liver cirrhosis, cardiac fibrosis, progressive kidney disease, and idiopathic pulmonary fibrosis. The hallmark of fibrosis is tissue remodeling with ...
Barry S Shea,Andrew M Tager
Barry S Shea
Bioactive sphingolipids, such as sphingosine 1-phosphate (S1P), dihydrosphingosine 1-phosphate (dhS1P) and ceramide, regulate a diverse array of cellular processes. Many of these processes are important components of wound-healing responses...
Elena Tourkina,Stanley Hoffman
Elena Tourkina
Caveolin-1 is a master regulator of several signaling cascades because it is able to bind to and thereby inhibit members of a variety of kinase families. While associated with caveolae and involved in their generation, caveolin-1 is also pr...
Regulation of Matrix Remodeling by Peroxisome Proliferator-Activated Receptor-γ: A Novel Link Between Metabolism and Fibrogenesis [0.03%]
过氧化物酶体增殖激活受体γ调控基质重塑：代谢与纤维化间的全新纽带
Jun Wei,Swati Bhattacharyya,Manu Jain et al.
Jun Wei et al.
The intractable process of fibrosis underlies the pathogenesis of systemic sclerosis (SSc) and other diseases, and in aggregate contributes to 45% of deaths worldwide. Because currently there is no effective anti-fibrotic therapy, a better ...