Comparative efficacy and safety study of two chondroitin sulfate preparations from different origin (avian and bovine) in symptomatic osteoarthritis of the knee [0.03%]
不同来源（禽类和牛类）硫酸软骨素治疗膝关节症状性骨关节炎的疗效与安全性比较研究
Patrice Fardellone,Mohammed Zaim,Anne-Sophie Saurel et al.
Patrice Fardellone et al.
Introduction: Some argued that clinical efficacy of Chondroitin Sulfate (CS) could vary upon the product origin. The objective of this trial is to compare the effect of 2 CS medicinal products from different origin: Struc...
Mart van Laar,Joseph V Pergolizzi Jr,Hans-Ulrich Mellinghoff et al.
Mart van Laar et al.
Managing pain from chronic conditions, such as, but not limited to, osteoarthritis and rheumatoid arthritis, requires the clinician to balance the need for effective analgesia against safety risks associated with analgesic agents. Osteoarth...
Hani Almoallim,Yahya Al-Ghamdi,Haneen Almaghrabi et al.
Hani Almoallim et al.
Anti-tumor necrosis factor-alpha induced lupus (ATIL) represents a major diagnostic and therapeutic challenge. Most cases of ATIL are caused by infliximab, followed by etanercept and adalimumab. Symptoms can range from common, mild cutaneou...
Line Heylen,Daan Dierickx,Peter Vandenberghe et al.
Line Heylen et al.
Felty's syndrome is a rare, severe extra-articular manifestation of rheumatoid arthritis (RA). There is no standard therapy, and several disease-modifying antirheumatic drugs have been used with varying success. Only very few reports exist ...
Barbara Legius,Kristel Van Landuyt,Patrick Verschueren et al.
Barbara Legius et al.
A septic arthritis due to an indolent infection is a challenge for timely diagnosis. In recent years septic arthritides due to Staphylococcus Warneri are increasingly reported, mostly as a complication in patients with prosthetic devices. W...
The Effect of Stopping Smoking on Disease Activity in Rheumatoid Arthritis (RA). Data from BARFOT, a Multicenter Study of Early RA [0.03%]
吸烟与早期类风湿关节炎病情活动度关系的研究BARFOT研究数据
Maria LE Andersson,Stefan Bergman,Maria K Söderlin
Maria LE Andersson
Objective: We studied the effect of stopping smoking on disease activity in patients with RA. Methods: Between 1992 and 2005, 2,800 adu...
Is the deficit in pain inhibition in fibromyalgia influenced by sleep impairments? [0.03%]
纤维肌痛患者的镇痛抑制缺陷受睡眠障碍的影响吗？
Emilie Paul-Savoie,Serge Marchand,Mélanie Morin et al.
Emilie Paul-Savoie et al.
It has been proposed that a deficit in inhibitory conditioned pain modulation (ICPM) underlies the pathophysiology of fibromyalgia (FM), but there is high variability in ICPM efficacy in this syndrome that remains poorly understood. Based o...
Foot problems in a group of patients with rheumatoid arthritis: an unmet need for foot care [0.03%]
类风湿性关节炎患者足病问题：亟需开展足部护理
Pinar Borman,Figen Ayhan,Figen Tuncay et al.
Pinar Borman et al.
Objectives: The aim of this study was to evaluate the foot involvement in a group of RA patients in regard to symptoms, type and frequency of deformities, location, radiological changes, and foot care. ...
Signal transduction pathways in chronic inflammatory autoimmune disease: small GTPases [0.03%]
慢性炎症自身免疫病中的信号转导途径：小G蛋白酶
Kris A Reedquist,Paul P Tak
Kris A Reedquist
Ras superfamily small GTPases represent a wide and diverse class of intracellular signaling proteins that are highly conserved during evolution. These enzymes serve as key checkpoints in coupling antigen receptor, growth factor, cytokine an...
The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases [0.03%]
PI3K抑制剂在自身免疫性疾病治疗中的潜力
Edward Banham-Hall,Menna R Clatworthy,Klaus Okkenhaug
Edward Banham-Hall
The class 1 PI3Ks are lipid kinases with key roles in cell surface receptor-triggered signal transduction pathways. Two isoforms of the catalytic subunits, p110γ and p110δ, are enriched in leucocytes in which they promote activation, cell...