Adaptation of Mycobacterium smegmatis to an Industrial Scale Medium and Isolation of the Mycobacterial PorinMspA [0.03%]
龟分枝杆菌适应工业培养基及分支杆菌Porin MspA的分离鉴定
Sebastian O Wendel,Ayomi S Perera,Peter H Pfromm et al.
Sebastian O Wendel et al.
The adaptation of the organism to a simple and cost-effective growth medium is mandatory in developing a process for large scale production of the octamericporinMspA, which is isolated from Mycobacterium smegmatis. A fermentation optimizati...
The Aggregation of Brucella abortus Occurs Under Microaerobic Conditions and Promotes Desiccation Tolerance and Biofilm Formation [0.03%]
布氏杆菌在微需氧条件下聚集并促进干燥耐受性和生物被膜形成
Marta A Almirón,Mara S Roset,Norberto Sanjuan
Marta A Almirón
Brucella abortus causes brucellosis mainly in cattle. The infection is transmitted to humans by ingestion of animal products or direct contact with infected material. While the intracellular lifestyle of Brucella is well characterized, its ...
A Simple Method for Assessment of MDR Bacteria for Over-Expressed Efflux Pumps [0.03%]
评估多药耐药细菌过表达外排泵的简便方法
Marta Martins,Matthew P McCusker,Miguel Viveiros et al.
Marta Martins et al.
It is known that bacteria showing a multi-drug resistance phenotype use several mechanisms to overcome the action of antibiotics. As a result, this phenotype can be a result of several mechanisms or a combination of thereof. The main mechan...
Sofia Santos Costa,Miguel Viveiros,Leonard Amaral et al.
Sofia Santos Costa et al.
The emergence of infections caused by multi- or pan-resistant bacteria in the hospital or in the community settings is an increasing health concern. Albeit there is no single resistance mechanism behind multiresistance, multidrug efflux pum...
Microbial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementation [0.03%]
微生物外排系统及抑制剂：药物发现方法与临床应用挑战
Christina Kourtesi,Anthony R Ball,Ying-Ying Huang et al.
Christina Kourtesi et al.
Conventional antimicrobials are increasingly ineffective due to the emergence of multidrug-resistance among pathogenic microorganisms. The need to overcome these deficiencies has triggered exploration for novel and unconventional approaches...
Structure, Function and Regulation of Outer Membrane Proteins Involved in Drug Transport in Enterobactericeae: the OmpF/C - TolC Case [0.03%]
肠杆菌科药物转运外膜蛋白的结构、功能及调控：OmpF/C-TolC为例
Muriel Masi,Jean-Marie Pagès
Muriel Masi
Antibiotic translocation across membranes of Gram-negative bacteria is a key step for the activity on their specific intracellular targets. Resistant bacteria control their membrane permeability as a first line of defense to protect themsel...
Pimozide Inhibits the AcrAB-TolC Efflux Pump in Escherichia coli [0.03%]
哌泊西平通过抑制大肠杆菌AcrAB-_tolC外排泵发挥抗菌作用
Jürgen A Bohnert,Sabine Schuster,Winfried V Kern
Jürgen A Bohnert
Efflux pump inhibitors (EPIs) are attractive compounds to reverse multidrug-resistance in clinically relevant bacterial pathogens. In this study we tested the ability of the neuroleptic drug pimozide to inhibit the Escherichia coli AcrAB-To...
Ana Martins,Attila Hunyadi,Leonard Amaral
Ana Martins
Acquisition of resistance is one of the major causes of failure in therapy of bacterial infections. According to the World Health Organization (WHO), thousands of deaths caused by Salmonella sp., Escherichia coli, Staphylococcus aureus or M...
Phenotypic and Genotypic Characterization of Escherichia coli Isolated from Untreated Surface Waters [0.03%]
来自未经处理地表水的大肠杆菌的表型及基因型特征分析
Kristopher J Janezic,Blake Ferry,Eric W Hendricks et al.
Kristopher J Janezic et al.
A common member of the intestinal microbiota in humans and animals is Escherichia coli. Based on the presence of virulence factors, E. coli can be potentially pathogenic. The focus of this study was to isolate E. coli from untreated surface...
Cross-contamination: Comparison of Nasal and Chronic Leg Ulcer Staphylococcus aureus Strains Isolated from the Same Patient [0.03%]
交叉感染：来自同一患者的鼻腔和慢性腿部溃疡的金黄色葡萄球菌菌株的比较研究
Kristine Gjødsbøl,Mette Elena Skindersoe,Robert Leo Skov et al.
Kristine Gjødsbøl et al.
The aim of this study was to investigate the occurrence of bacterial cross-contamination between the nasal cavity and leg ulcers. Sixteen patients were included in the study. Staphylococcus aureus was isolated from the leg ulcer of 13 patie...