1H, 13C and 15N resonance assignments of a shark variable new antigen receptor against hyaluronan synthase [0.03%]
鲨鱼可变新抗原受体的共振谱分配对抗透明质酸合成酶
Yuxin Liu,Hao Wang,Cookson K C Chiu et al.
Yuxin Liu et al.
Single domain antibody (sdAb) is only composed of a variable domain of the heavy-chain-only antibody, which is devoid of light chain and naturally occurring in camelids and cartilaginous fishes. Variable New Antigen Receptor (VNAR), a type ...
Manual and automatic assignment of two different Aβ40 amyloid fibril polymorphs using MAS solid-state NMR spectroscopy [0.03%]
利用固体状态NMR技术对两种不同的Aβ40淀粉样纤维多晶型进行手动和自动分配
Natalia Rodina,Riddhiman Sarkar,Dimitrios Tsakalos et al.
Natalia Rodina et al.
Amyloid fibrils from Alzheimer's amyloid-beta peptides (Aβ) are found to be polymorphic. So far, 14 Aβ40 fibril structures have been determined. The mechanism of why one particular protein sequence adopts so many different three-dimension...
1H, 13C and 15N assignment of self-complemented MrkA protein antigen from Klebsiella pneumoniae [0.03%]
克雷伯氏肺炎菌自我互补的MrkA蛋白抗原的氢-1，碳-13和氮-15归属化研究
Valentina Monaci,Gianmarco Gasperini,Lucia Banci et al.
Valentina Monaci et al.
Klebsiella pneumoniae (Kp) poses an escalating threat to public health, particularly given its association with nosocomial infections and its emergence as a leading cause of neonatal sepsis, particularly in low- and middle-income countries ...
Solid-state NMR assignment of α-synuclein polymorph prepared from helical intermediate [0.03%]
由螺旋中间体制备的α-突触核蛋白多态固体核磁共振 ASSIGNMENT
Sahil Ahlawat,Surabhi Mehra,Chandrakala M Gowda et al.
Sahil Ahlawat et al.
Synucleinopathies are neurodegenerative diseases characterized by the accumulation of α-synuclein protein aggregates in the neurons and glial cells. Both ex vivo and in vitro α-synuclein fibrils tend to show polymorphism. Polymorphism res...
Solid-state NMR backbone chemical shift assignments of α-synuclein amyloid fibrils at fast MAS regime [0.03%]
固态NMR研究α-突触核蛋白淀粉样纤维主链化学位移快速MAS制度
Zigmantas Toleikis,Piotr Paluch,Ewelina Kuc et al.
Zigmantas Toleikis et al.
The α-synuclein (α-syn) amyloid fibrils are involved in various neurogenerative diseases. Solid-state NMR (ssNMR) has been showed as a powerful tool to study α-syn aggregates. Here, we report the 1H, 13C and 15N back-bone chemical shifts...
Backbone and methyl side-chain resonance assignments of the Fab fragment of adalimumab [0.03%]
阿达木单抗Fab段的主链及甲基侧链共振峰指认
Muzaddid Sarker,Yves Aubin
Muzaddid Sarker
Adalimumab is a therapeutic monoclonal antibody developed to target human TNF an important mediator of immune-mediated inflammatory diseases such as rheumatoid arthritis, amongst others. The 48 kDa Fab fragment of adalimumab was produced in...
Assignment of the Lassa virus transmembrane domain in the prefusion and postfusion states in detergent micelles [0.03%]
阳离子去垢剂胶束中拉沙热病毒融合前后跨膜结构域的定位研究
Patrick M Keating,Jinwoo Lee
Patrick M Keating
Lassa virus (LASV) is the most prevalent member of the arenavirus family and the causative agent of Lassa fever, a viral hemorrhagic fever. Although there are annual outbreaks in West Africa, and recently isolated cases worldwide, there are...
NMR resonance assignment of the cell death execution domain BELL2 from multicellular bacterial signalosomes [0.03%]
来源于多细胞细菌信号体的细胞死亡执行域BELL2的核磁共振共振归属
Loic Delcourte,Corinne Sanchez,Estelle Morvan et al.
Loic Delcourte et al.
Signalosomes are high-order protein machineries involved in complex mechanisms controlling regulated immune defense and cell death execution. The immune response is initiated by the recognition of exogeneous or endogenous signals, triggerin...
Backbone NMR resonance assignments for the VP1u N-terminal receptor-binding domain of the human parvovirus pathogen B19 [0.03%]
人细小病毒B19 VP1u氨基末端受体结合域的骨干核磁共振共振峰指认
Maria Luiza Caldas Nogueira,Renuk Lakshmanan,Gwladys Rivière et al.
Maria Luiza Caldas Nogueira et al.
Parvovirus B19 (B19V) is a human pathogen that is the causative agent of several diseases in infants and adults. Due to a lack of antivirals against this virus, treatment options are limited. The minor capsid protein of B19V has a unique N ...
1H, 13C and 15N backbone resonance assignment of Cel45A from Phanerochaete chrysosporium [0.03%]
Phanerochaete chrysosporium纤维素酶Cel45A的氢-碳-氮化学 shifts背骨共振 assignments
Laura Okmane,Mats Sandgren,Jerry Ståhlberg et al.
Laura Okmane et al.
A glycoside hydrolase family 45 (GH45) enzyme from the white-rot basidiomycete fungus Phanerochaete chrysosporium (PcCel45A) was expressed in Pichia pastoris with 13C and 15N labelling. A nearly complete assignment of 1H, 13C and 15N backbo...