Practical Guidance on How to Handle Levodopa/Carbidopa Intestinal Gel Therapy of Advanced PD in a Movement Disorder Clinic [0.03%]
运动障碍病门诊帕金森病肠凝胶泵治疗利舍平/卡比多巴的临床应用指导意见
Stephen Wørlich Pedersen,Jesper Clausen,Mie Manon Gregerslund
Stephen Wørlich Pedersen
Continuous dopaminergic delivery is recognized for the capacity to ameliorate symptoms in Parkinson's disease (PD). In advanced PD the short comings of orally administered Levodopa/Carbidopa include fluctuations resulting in unstable effect...
Transdermal lidocaine and ketamine for neuropathic pain: a study of effectiveness and tolerability [0.03%]
用于神经痛的利多卡因和氯胺酮贴剂：有效性和耐受性研究
Emily Tam,Andrea D Furlan
Emily Tam
Background: Acute neuropathic pain is a common disorder. Transdermal cream could be an alternative to oral medications. Objective: To e...
The Relation of Urinary 8-OHdG, A Marker of Oxidative Stress to DNA, and Clinical Outcomes for Ischemic Stroke [0.03%]
尿液中氧化应激标志物8-羟基脱氧鸟苷与缺血性卒中临床结局的关系
Hideto Nakajima,Ki-Ichi Unoda,Takumi Ito et al.
Hideto Nakajima et al.
Background: Oxidative stress/free radical generation after ischemic stroke contributes to neuronal cell injury. We evaluated the utility of an oxidative stress marker, urinary 8-hydroxy-2-deoxyguanosine (8-OHdG), to demon...
Josef Finsterer
Josef Finsterer
Background: Though not obvious at a first glance, myopathies may be associated with ischemic stroke. Stroke-like episodes resemble ischemic stroke only to some extent but are a unique feature of certain mitochondrial diso...
J Sonn,A Mayevsky
J Sonn
Objectives: The effect of cortical spreading depression (CSD) on extracellular K(+) concentrations ([K(+)](e)), cerebral blood flow (CBF), mitochondrial NADH redox state and direct current (DC) potential was studied durin...
Igor Grant,J Hampton Atkinson,Ben Gouaux et al.
Igor Grant et al.
Recent advances in understanding of the mode of action of tetrahydrocannabinol and related cannabinoid in-gredients of marijuana, plus the accumulating anecdotal reports on potential medical benefits have spurred increasing re-search into p...
Genetic Screening of the Mitochondrial Rho GTPases MIRO1 and MIRO2 in Parkinson's Disease [0.03%]
帕金森病的线粒体Rho GTP酶MIRO1和MIRO2的基因筛查
Anna Anvret,Caroline Ran,Marie Westerlund et al.
Anna Anvret et al.
MIRO1 and MIRO2 (mitochondrial Ras homolog gene family, member T1 and T2) also referred to as RHOT1 and RHOT2, belong to the mitochondrial Rho GTPase family and are involved in axonal transport of mitochondria in neurons. Because mitochondr...
Predictors of attack severity and duration in multiple sclerosis: a prospective study [0.03%]
预测多发性硬化症攻击严重程度和持续时间的因素：一项前瞻性研究
P Naldi,L Collimedaglia,D Vecchio et al.
P Naldi et al.
Objective: To evaluate predictors of severity and duration of early Multiple Sclerosis (MS) attacks. Methods: We analyzed 248 attacks i...
An immunological analysis of dystroglycan subunits: lessons learned from a small cohort of non-congenital dystrophic patients [0.03%]
糖蛋白聚糖亚单位的免疫学分析：从一组非先天性营养不良患者的初步研究中得到的经验教训
Ernesto Pavoni,Francesca Sciandra,Giorgio Tasca et al.
Ernesto Pavoni et al.
The dystroglycan (DG) expression pattern can be altered in severe muscular dystrophies. In fact, some congenital muscular dystrophies (CMDs) and limb-girdle muscular dystrophies (LGMDs) are caused by point mutations identified in six glycos...
Silvia Kochen,Constanza Salera,Josef Seni
Silvia Kochen
This is the first prospective study carried out in Argentina and Latin America to provide the impact of epilepsy throughout the childbearing years life of women, and pregnancy outcome in a population of pregnant women with diagnosis of epil...