An Emerging Natural History in the Development, Mechanisms and Worldwide Prevalence of Major Mental Disorders [0.03%]
重大精神疾病的发展、机制及全球流行现状的自然史研究初探
Nicholas Pediaditakis
Nicholas Pediaditakis
Conciliating recent findings from molecular genetics, evolutionary biology, and clinical observations together point to new understandings regarding the mechanism, development and the persistent worldwide prevalence of major mental disorder...
Functional and Genomic Features of Human Genes Mutated in Neuropsychiatric Disorders [0.03%]
神经精神疾病人类基因组突变的功能和基因组特征分析
Diego A Forero,Carlos F Prada,George Perry
Diego A Forero
Background: In recent years, a large number of studies around the world have led to the identification of causal genes for hereditary types of common and rare neurological and psychiatric disorders. ...
Rudy J Castellani,Gruschenka Mojica,George Perry
Rudy J Castellani
The timing of the breakdown of red blood cells and organization of hemorrhage has significance in the catabolism of heme and the processing of iron, but also has a practical application in terms of assigning, or attempting to assign, a time...
Relationship Between Patients with Clinical Auditory Neuropathy Spectrum Disorder and Mutations in Gjb2 Gene [0.03%]
临床听神经病谱系障碍患者与GJB2基因突变的关系分析
Guilherme M de Carvalho,Priscila Z Ramos,Arthur M Castilho et al.
Guilherme M de Carvalho et al.
The auditory neuropathy is a condition which there is a dyssynchrony in the nerve conduction of the auditory nerve fibers. There is no evidence about the relationship between patients with clinical auditory neuropathy spectrum disorder and ...
Review: Cav2.3 R-type Voltage-Gated Ca2+ Channels - Functional Implications in Convulsive and Non-convulsive Seizure Activity [0.03%]
钙通道Cav2.3的突触前R型电流在惊厥和非惊厥性癫痫活动的功能意义：综述
Carola Wormuth,Andreas Lundt,Christina Henseler et al.
Carola Wormuth et al.
Background: Researchers have gained substantial insight into mechanisms of synaptic transmission, hyperexcitability, excitotoxicity and neurodegeneration within the last decades. Voltage-gated Ca2+ channels are of central...
Molecular Mapping Alzheimer's Disease: MALDI Imaging of Formalin-fixed, Paraffin-embedded Human Hippocampal Tissue [0.03%]
基质辅助激光解析电离阿尔茨海默病分子影像学研究：石蜡包埋人脑海马组织的成像分析
Andrea R Kelley,George Perry,Chloe Bethea et al.
Andrea R Kelley et al.
A method for the molecular mapping of formalin-fixed, paraffin-embedded human hippocampal tissue affected by Alzheimer's disease (AD) is presented. This approach utilizes imaging mass spectrometry (IMS) with matrix-assisted laser desorption...
Nona Aryan,Brandi S Betts-Obregon,George Perry et al.
Nona Aryan et al.
The aim of this research is to determine whether oxidative stress induces cellular senescence in human retinal pigment epithelial cells. Cultured ARPE19 cells were subjected to different concentrations of hydrogen peroxide to induce oxidati...
L Bertolasi,A Danese,S Monaco et al.
L Bertolasi et al.
Background: Poliomyelitis was before the immunization an important medical problem. Nowadays polio prior patients (PP) suffer from polio sequelae or have developed post-polio-syndrome (PPS) with increasing paresis, pain a...
Are Temporal Differences in GDNF and NOS Isoform Induction Contributors to Neurodegeneration? A Fluorescence Microscopy-Based Study [0.03%]
基于荧光显微镜的神经退行性疾病相关研究：脑源性神经营养因子和一氧化氮合酶异构体诱导的时间差异的影响作用？
Marie-Francoise Doursout,Yangyan Liang,Mya C Schiess et al.
Marie-Francoise Doursout et al.
Background: Specific factors in Parkinson's disease have become targets as to their protective and degenerative effects. We have demonstrated that cytokines and PD-CSF detrimentally affect microglia and astrocyte growth. ...
Osteopathic Manual Treatment for Amyotrophic Lateral Sclerosis: A Feasibility Pilot Study [0.03%]
肌萎缩侧索硬化症的整骨治疗：一项可行性试点研究
Alberto Maggiani,Lucio Tremolizzo,Andrea Della Valentina et al.
Alberto Maggiani et al.
Background: Current interventions in amyotrophic lateral sclerosis (ALS) are focused on supporting quality of life (QoL) and easing pain with a multidisciplinary approach. ...