Endothelial cell senescence: A core mechanism in the development of cardiovascular metabolic diseases [0.03%]
内皮细胞衰老：心血管代谢病发生发展核心机制
Xu Yang,Lijin Wang,Yunyun Liu et al.
Xu Yang et al.
Endothelial cells (ECs), as integral components of the vascular intima, play a pivotal role in the regulation of vascular tone, maintenance of blood flow homeostasis, and control of inflammatory responses. In response to pathological insult...
SGLT2 inhibitors therapy in patients with acute Takotsubo syndrome [0.03%]
急性应激性心肌病患者中钠-葡萄糖协同转运蛋白2抑制剂的使用
Luca Arcari,Giovanni Camastra,Matteo Sclafani et al.
Luca Arcari et al.
Background: SGLT2 inhibitors are approved for heart failure treatment, however, few data are available in patients with takotsubo syndrome (TTS). We aim to evaluate the safety, tolerability and effects of SGLT2 inhibitors...
Dilated cardiomyopathy vs. non-dilated left ventricular dysfunction: genotype-phenotype relationship and outcome [0.03%]
扩张型心肌病与非扩张型左室功能不全：基因型-表型关系及预后研究
Irina Bellisario,Alberto Aimo,Giancarlo Todiere et al.
Irina Bellisario et al.
Background: Dilated cardiomyopathy (DCM) and non-dilated left ventricular (LV) dysfunction (NDLVD) comprise patients with heterogeneous genetics and prognosis. This study aimed to investigate genotype-phenotype relationsh...
Strain detects substrate: Pioneering non-invasive visualization of atrial electropathology [0.03%]
应变检测底物：心房电病理非侵入可视化前沿技术
Manouk H C Linderhof,Anouk I Freriks,Elisa C H van Doorn et al.
Manouk H C Linderhof et al.
Background: Non-invasive assessment of arrhythmogenic substrates underlying persistent atrial fibrillation (AF) could potentially provide patient-tailored ablation therapy. Speckle Tracking Echocardiography (STE) is an im...
Racial differences in natriuretic peptide levels in wild type transthyretin amyloid cardiomyopathy [0.03%]
野生型转甲状腺素蛋白淀粉样心肌病中种族差异的利钠肽水平
Brian C Boursiquot,Muhammad Ali Khan,Sergio Teruya et al.
Brian C Boursiquot et al.
Introduction: Black individuals have significantly lower serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels than White individuals in the general population. Racial differences in NT-proBNP have not been w...
Population and family data support TNNT2 p.Arg288Cys as an intermediate effect variant in hypertrophic cardiomyopathy [0.03%]
人群和家系数据支持TNNT2 p.Arg288Cys是肥厚型心肌病的中间效应变异型
Talitha C F Spanjersberg,Fahima Hassanzada,Jan D H Jongbloed et al.
Talitha C F Spanjersberg et al.
Background: The TNNT2 (NM_001276345.2):c.862C>T, p.Arg288Cys variant has conflicting pathogenicity classifications. It is reported in individuals with severe hypertrophic cardiomyopathy (HCM) yet also occurs in the genera...
Early development and SGLT2 inhibitor-mediated reversal of coronary microvascular dysfunction in an isoprenaline-induced murine HFpEF model: Insights from multimodal in vivo imaging [0.03%]
异丙肾上腺素诱导的HFpEF小鼠模型中冠状微血管功能障碍的早期发展及SGLT2抑制剂介导的功能恢复：多模式体内成像研究的新见解
Grzegorz Kwiatkowski,Izabela Czyzynska-Cichon,Anna M Gdula et al.
Grzegorz Kwiatkowski et al.
Background: Coronary microvascular dysfunction (CMD) is increasingly recognized as a mechanistically relevant contributor to HFpEF, yet the temporal and causal relationship between early functional CMD, coronary microvasc...
Drug-coated balloon versus drug-eluting stent for treating de novo proximal left anterior descending artery lesions: Insights from the REC-CAGEFREE I trial [0.03%]
药物涂层球囊与药物洗脱支架治疗原发性左前降支近端病变的疗效：REC-CAGEFREE I研究启示
Aiyuan Cheng,Yanqing Wu,Fangjun Mou et al.
Aiyuan Cheng et al.
Background: The safety and efficacy of drug-coated balloon (DCB) angioplasty for the treatment of proximal left anterior descending (LAD) lesions remain unclear. We aim to assess the prognosis of DCB versus drug-eluting s...
Timing of cardiogenic shock and clinical outcomes in takotsubo syndrome: A multicenter cohort study [0.03%]
takoşetto综合征心源性休克的发生时间及其临床结局：一项多中心队列研究
Jordi Sans-Roselló,Estefanía Fernández-Peregrina,Kayode O Kuku et al.
Jordi Sans-Roselló et al.
Background: Takotsubo syndrome (TTS) may be complicated by cardiogenic shock (CS), a life-threatening condition that worsens prognosis. Whether the timing of CS onset-at admission or during hospitalization-provides progno...
Impact of absolute stent expansion on two-year clinical outcomes after PCI in patients with acute coronary syndrome: Results from the OCT-guided PCI registry (TACTICS registry) [0.03%]
光学 coherence 血管内断层扫描技术指导下的经皮冠状动脉介入治疗术2年临床疗效的决定因素：TIMI 15亚研究
Myong Hwa Yamamoto,Takuya Mizukami,Hiroyoshi Mori et al.
Myong Hwa Yamamoto et al.
Background: Stent expansion is a crucial determinant of chronic coronary syndrome outcomes; however, its clinical impact and factors limiting optimal expansion in acute coronary syndrome (ACS) treated with optical coheren...