Molecular docking and analysis of survivin delta-ex3 isoform protein [0.03%]
SurvivinΔex3蛋白的分子对接及分析研究
Z Ezziane
Z Ezziane
This project explores molecular models of Survivin Delta-Ex3, H-Ras, and their binding sites, and generates energy optimized 3D coordinates of docked poses and conformations of the XY2 ligand molecule in the active site of Delta-Ex3. The ai...
Juha Horsti,Helena Uppa,Juhani A Vilpo
Juha Horsti
Prothrombin time (PT) is the leading test for monitoring oral anticoagulation therapy (OAT). We sought to determine INR taking into account only active coagulation factors FII, FVII and FX without inhibition in patient plasmas and calibrato...
Important bioactive molecules of erythrocytes in colorectal cancer patients after colectomy [0.03%]
结肠癌患者结肠切除术后红细胞的重要生物活性分子
Anna Blázovics,Agnes Szilvás,György Székely et al.
Anna Blázovics et al.
Formaldehyde (HCHO) and protoporphyrin, are in connection with redox homeostasis. Data show the importance of HCHO in proliferative as well as in apoptotic processes. Free protoporphyrin can be detected near the Zn-protoporphyrin in cancer ...
Chronic experimental diabetes accelerates urinary elimination of deprenyl and its metabolites [0.03%]
慢性实验性糖尿病加速左旋雷尼替丁及其代谢物的尿排泄
Ernest Adeghate,Péter Sótonyi Jr,Huba Kalász
Ernest Adeghate
Many diabetic patients take several medications to treat diabetes-associated complications and other ailments. The mode of elimination of these drugs and their metabolites are poorly understood. The elimination of deprenyl, a MAO-B inhibito...
Heteroarotinoids with anti-cancer activity against ovarian cancer cells [0.03%]
具有抗卵巢癌细胞活性的杂环维甲酸类化合物
Thanh C Le,K Darrell Berlin,Stacy D Benson et al.
Thanh C Le et al.
The Flex-Het compound 10a (SHetA2-NSC 721689) {[4-nitrophenylamino][(2,2,4,4-tetramethylthiochroman-6-yl)amino]methane-1-thione]} has shown promise in preclinical testing as an anti-cancer agent without evidence of toxicity, skin irritancy,...
Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors [0.03%]
一类新型3-芳基-n-甲基四氢吡啶衍生物的合成及其乙酰胆碱酯酶抑制活性研究
S B Benaka Prasad,Y C Sunil Kumar,C S Ananda Kumar et al.
S B Benaka Prasad et al.
Alzheimer's disease (AD) is a neurodegenerative disorder affecting the central nervous system, which is also associated with progressive loss of memory and cognition. The development of numerous structural classes of compounds with differen...
A Tsotinis,S Zouroudis,D Moreau et al.
A Tsotinis et al.
A facile synthesis of the C4-substituted isoquinolines 5a-c and 6a-c is described. Commercially available 4-bromoisoquinoline is converted to the alpha,beta-unsaturated esters 8 and 10 on treatment with the appropriate acrylate ester under ...