Kenji Hashimoto
Kenji Hashimoto
Multiple lines of evidence indicate that hypofunction of glutamatergic neurotransmission via N-methyl-D-aspartate (NMDA) receptors might be implicated in the pathophysiology of schizophrenia, suggesting that increasing NMDA receptor functio...
A Single Amino Acid Substitution Makes WNK4 Susceptible to SB 203580 and SB 202190 [0.03%]
单个氨基酸的取代使WNK4易受SB 203580和SB 202190的影响
Mark Glover,Connor Sweeny,Bill Davis et al.
Mark Glover et al.
Regulation of the SLC12 family of membrane transporters including NCCT involves a scaffold of interacting proteins including the STE 20 kinase SPAK and the WNK kinases, WNK 1 and WNK 4, which are mutated in the hypertensive syndrome of pseu...
α7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer's Disease [0.03%]
乙酰胆碱受体激动剂在精神分裂症和阿尔茨海默病认知障碍治疗中的应用前景研究进展
Jun Toyohara,Kenji Hashimoto
Jun Toyohara
Accumulating evidence suggests that α7 nicotinic receptors (α7 nAChRs), a subtype of nAChRs, play a role in the pathophysiology of neuropsychiatric diseases, including schizophrenia and Alzheimer's disease (AD). A number of psychopharmaco...
Metabotropic glutamate receptors: potential drug targets for psychiatric disorders [0.03%]
代谢型谷氨酸受体：精神疾病的药物靶点潜力
Akito Yasuhara,Shigeyuki Chaki
Akito Yasuhara
Metabotropic glutamate receptors (mGlu receptors) have emerged as new therapeutic targets for psychiatric disorders, such as schizophrenia, depression and anxiety with their regulatory roles in glutamatergic transmissions. To date, several ...
Kenji Hashimoto
Kenji Hashimoto
Sean M Smith,Jason M Uslaner,Peter H Hutson
Sean M Smith
D-amino acid oxidase (DAAO) is a flavoenzyme that degrades D-amino acids through the process of oxidative deamination. DAAO regulation of D-amino acid levels has been associated with several physiological processes ranging from hormone secr...
Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors [0.03%]
设计并合成一类有效的iNOS二聚化抑制剂imidazopyrimidine衍生物
Guo-Hua Chu,Bertrand Le Bourdonnec,Minghua Gu et al.
Guo-Hua Chu et al.
A series of imidazopyrimidine derivatives with the general formula I was synthesized and identified as potent inhibitors of iNOS dimer formation, a prerequisite for proper functioning of the enzyme. Stille and Negishi coupling reactions wer...
Monitoring by HPLC of chamomile flavonoids exposed to rat liver microsomal metabolism [0.03%]
高效液相色谱法监测鼠肝微粒体代谢后洋甘菊黄酮类化合物的变化
Georg Petroianu,Eva Szoke,Huba Kalász et al.
Georg Petroianu et al.
Three major flavonoid chamomile components (quercetin, apigenin-7-O-glucoside and rutin) were subjected to oxidative metabolism by cytochrome P-450 of rat liver microsomal preparations. Changes over time in their respective concentrations w...
Cyclobutane-containing alkaloids: origin, synthesis, and biological activities [0.03%]
含环丁烷生物碱：起源、合成及生物活性研究进展
Anastasia Sergeiko,Vladimir V Poroikov,Lumir O Hanus et al.
Anastasia Sergeiko et al.
Present review describes research on novel natural cyclobutane-containing alkaloids isolated from terrestrial and marine species. More than 60 biological active compounds have been confirmed to have antimicrobial, antibacterial, antitumor, ...
Two- and three-dimensional quantitative structure-activity relationships studies on a series of liver x receptor ligands [0.03%]
肝X受体配体一系列化合物的二维和三维定量构效关系研究
Káthia M Honório,Lívia B Salum,Richard C Garratt et al.
Káthia M Honório et al.
Liver X receptor (LXR) is an attractive drug target for the development of novel therapeutic agents for the treatment of dyslipidaemia and cholestasis. In the present work, comparative molecular field analysis (CoMFA) and hologram quantitat...