Medicinal chemistry of the anti-diabetic effects of momordica charantia: active constituents and modes of actions [0.03%]
苦瓜的抗糖尿病作用机制研究：活性成分及作用方式
Jaipaul Singh,Emmanuel Cumming,Gunasekar Manoharan et al.
Jaipaul Singh et al.
Diabetes mellitus (DM) is one of the oldest known human disease currently affecting more than 200 million people worldwide. Diabetes mellitus is derived from two Greek words meaning siphon and sugar. In DM, patients have high blood level of...
Ernest Adeghate
Ernest Adeghate
Kinetic analysis of some chalcones and synthetic chalcone analogues on the fenton-reaction initiated deoxyribose degradation assay [0.03%]
几种查尔康素和合成查尔康素类似物在芬顿反应诱导脱氧核糖降解试验中的动力学分析
Pál Perjési,Zsuzsanna Rozmer
Pál Perjési
Investigation of in vitro hydroxyl radical scavenging (antioxidant) effect 4-methoxychalcone (1a) and its cyclic analogues (2a-4a), as well as their hydroxyl substituted counterparts (1b-4b) was performed by means of the Fenton-reaction ini...
Acridine and acridinones: old and new structures with antimalarial activity [0.03%]
吖啶和吖叮酮：抗疟活性的已知与新结构
Aymé Fernández-Calienes Valdés
Aymé Fernández-Calienes Valdés
Since emergence of chloroquine-resistant Plasmodium falciparum and reports of parasite resistance to alternative drugs, there has been renewed interest in the antimalarial activity of acridines and their congeners, the acridinones. This art...
Julieta Coro Bermello,Rolando Pérez Piñeiro,Lianet Monzote Fidalgo et al.
Julieta Coro Bermello et al.
The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold have found many applications in recent years. This review is aimed at highlighting the most important aspects about these compounds: synthesis, spectroscopic characteri...
HIV Protease Inhibitors: Effect on the Opportunistic Protozoan Parasites [0.03%]
人类免疫缺陷病毒蛋白酶抑制剂对机会致病原虫的影响
Yenisey Alfonso,Lianet Monzote
Yenisey Alfonso
The impact of highly active antiretroviral therapy (HAART) in the natural history of AIDS disease has been allowed to prolong the survival of people with HIV infection, particularly whose with increased HIV viral load. Additionally, the ant...
Structures, targets and recent approaches in anti-leishmanial drug discovery and development [0.03%]
利什曼病药物研发中的结构、靶点及最新研究进展
Karin Seifert
Karin Seifert
Recent years have seen a significant improvement in available treatment options for leishmaniasis. Two new drugs, miltefosine and paromomycin, have been registered for the treatment of visceral leishmaniasis (VL) in India since 2002. Combin...
Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies [0.03%]
潜在抗T.克鲁氏锥虫候选物的筛选：体外和体内研究
Maria de Nazaré C Soeiro,Solange Lisboa de Castro
Maria de Nazaré C Soeiro
Chagas disease (CD), caused by the intracellular protozoan Trypanosoma cruzi, is a parasitic illness endemic in Latin America. In the centennial after CD discovery by Carlos Chagas (1909), although it still represents an important public he...
Mario Zucca,Dianella Savoia
Mario Zucca
Protozoan parasites cause serious human and zoonotic infections, including life-threatening diseases such as malaria, African and American trypanosomiasis, and leishmaniasis. These diseases are no more common in the developed world, but tog...
Lianet Monzote,Afshan Siddiq
Lianet Monzote
The diseases caused by protozoan parasite are responsible for considerable mortality and morbidity, affecting more than 500 million of people in the world. The epidemiological control of protozoan is unsatisfactory due to difficulties of ve...