Synthesis and Anticancer Evaluation of Some New 3-Benzyl-4,8-Dimethylbenzopyrone Derivatives [0.03%]
一些新的3-苯甲基-4,8-二甲基苯并吡酮衍生物的合成及抗肿瘤活性评价
Sohair L El-Ansary,Doaa E Abdel Rahman,Lina M A Abdel Ghany
Sohair L El-Ansary
Introduction: New benzopyrone derivatives such as Schiff's like compounds, acetohydrazides or substituted with oxadiazole or pyrazole heterocycles were synthesized from parent acid hydrazide compound 3. ...
Standardization of DNA Residual Quantification Method of Vero Cell Rabies Vaccine for Human Use [0.03%]
人用vero细胞狂犬疫苗余量DNA测定方法标准化研究
Janeth Del Carmen Arias Palacios,Carlos Alberto Barrero Barreto,José Salvador Montaña Lara et al.
Janeth Del Carmen Arias Palacios et al.
Objectives: Normalize the quantification of residual DNA from Vero cells in the rabies vaccine for use in human VAHV I, by quantitative PCR in real time and the design of primers that amplified, highly repetitive sequence...
Toxicity and Apoptosis Related Effects of Benzimidazo [3,2-α] Quinolinium Salts Upon Human Lymphoma Cells [0.03%]
苯并咪唑喹啉盐类化合物对人类淋巴瘤细胞毒性和诱导凋亡作用的研究
Christian Vélez,Jessica Soto,Karoline Ríos et al.
Christian Vélez et al.
Objectives: The present study evaluates novel cationic quinoline derivatives known as benzimidazo[3,2-a]quinolinium salts (BQS) named NBQ-48 and ABQ-48 that have structural similarities to known anti-cancer substances suc...
Tacrine, Trolox and Tryptoline as Lead Compounds for the Design and Synthesis of Multi-target Agents for Alzheimer's Disease Therapy [0.03%]
Tacrine，Trolox和Tryptoline作为多靶点阿尔茨海默病治疗药物设计与合成的先导化合物
Gerard A K Teponnou,Jacques Joubert,Sarel F Malan
Gerard A K Teponnou
The versatile biological activities of tacrine, trolox and β-carboline derivatives make them promising lead structures for the development of multifunctional Alzheimer's disease (AD) agents. Based on the topology of the active site of chol...
Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold [0.03%]
具有螺苯并吡喃支架的新型醛糖还原酶抑制剂的合成及功能评价
Maria Digiacomo,Stefania Sartini,Giulia Nesi et al.
Maria Digiacomo et al.
Background: Aldose reductase, the first enzyme of the polyol pathway, is the key determinant for the pathogenesis of long term diabetic complications. Accordingly, its inhibition represents the major therapeutic strategy ...
Monitoring the Level of 14C-Labelled Selegiline Following Oral Administration [0.03%]
口服给药后监测14C标记司来吉兰的水平
Huba Kalász,Kornélia Tekes,Erzsébet B Faigl et al.
Huba Kalász et al.
Background: Selegiline [(-)-deprenyl] is widely used for the treatment of Parkinson's disease in humans. Objective: Time-dependence of ...
Synthesis of Oxadiazolyl, Pyrazolyl and Thiazolyl Derivatives of Thiophene-2-Carboxamide as Antimicrobial and Anti-HCV Agents [0.03%]
作为抗菌和抗HCV药物的噻吩-2-甲酰胺类 oxadiazolyl，pyrazolyl 和 thiazolyl 衍生物的合成
Ola H Rizk,Omaima G Shaaban,Abeer E Abdel Wahab
Ola H Rizk
Introduction: Three series of pyrazole, thiazole and 1,3,4-oxadiazole, derivatives were synthesized starting from 5-amino-4-(hydrazinocarbonyl)-3-methylthiophene-2-carboxamide (2). ...
David Ramírez
David Ramírez
Due to the synergic relationship between medical chemistry, bioinformatics and molecular simulation, the development of new accurate computational tools for small molecules drug design has been rising over the last years. The main result is...
Development, Validation and Application of RP-HPLC Method: Simultaneous Determination of Antihistamine and Preservatives with Paracetamol in Liquid Formulations and Human Serum [0.03%]
开发、验证及应用RP-HPLC方法：同时测定液体剂型和人血清中解组胺药和防腐剂与对乙酰氨基酚的含量
Najmul Hasan,Mathurot Chaiharn,Umair Ali Toor et al.
Najmul Hasan et al.
In this article we describe development and validation of stability indicating, accurate, specific, precise and simple Ion-pairing RP-HPLC method for simultaneous determination of paracetamol and cetirizine HCl along with preservatives i.e....
Synthesis, Characterization, Antimicrobial and Antioxidant Activities of The Homocyclotrimer Of 4-Oxo-4h-Thieno[3,4-C]Chromene-3-Diazonium Sulfate [0.03%]
4-氧-4H噻诺[3,4-c]噌满-3-重氮硫酸盐的同 cyclotrimer的合成，表征及其抗菌和抗氧化活性研究
Emmanuel Sopbue Fondjo,Djeukoua Dimo Kamal Sorel,Tamokou Jean-de-Dieu et al.
Emmanuel Sopbue Fondjo et al.
The in situ formed 4-oxo-4H-thieno[3,4-c]chromene-3-diazonium sulfate (5) in the coupling reactions involving the parent 2-aminothiophene (4) and various phenolic and arylamines' couplers, readily undergoes homocyclotrimerization at low tem...