Oxidation of Hydroxy- and Dihydroxybenzoic Acids Under the Udenfriend's Conditions. An HPLC Study [0.03%]
关于羟基和二羟基苯甲酸的氧化反应（Udenfriend条件）一项HPLC研究
Mónika Kuzma,Nikoletta Kovács,Lilla Sziva et al.
Mónika Kuzma et al.
Background: Non-enzymatic hydroxylation of aromatic compounds to the respective phenolic derivatives is a possible metabolic pathway of xenobiotics. The formed metabolites can undergo consecutive oxidative reactions with ...
Bini Mathew,Judith V Hobrath,Michele C Connelly et al.
Bini Mathew et al.
Background: Sulindac belongs to the chemically diverse family of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) that effectively prevent adenomatous colorectal polyps and colon cancer, especially in patients with familial...
Intra Nasal In situ Gelling System of Lamotrigine Using Ion Activated Mucoadhesive Polymer [0.03%]
利用离子激活黏膜粘附聚合物制备的左乙拉西胺鼻用原位凝胶体系
Asha Paul,K M Fathima,Sreeja C Nair
Asha Paul
Background: A novel drug delivery system for treating acute epileptic condition. Objective: To develop an intranasal mucoadhesive formu...
Ezqsar: An R Package for Developing QSAR Models Directly From Structures [0.03%]
Ezqsar：一个直接基于结构开发QSAR模型的R包
Jamal Shamsara
Jamal Shamsara
Background: Quantitative Structure Activity Relationship (QSAR) is a difficult computational chemistry approach for beginner scientists and a time consuming one for even more experienced researchers. ...
Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties [0.03%]
含嘌呤、香豆素及异噁唑啉或异噁唑类新杂环化合物的设计合成及活性评价
Michael G Kallitsakis,Angelo Carotti,Marco Catto et al.
Michael G Kallitsakis et al.
Introduction: The 1,3-dipolar cycloaddition reactions of nitrile oxides formed in situ (in the presence of NCS and Et3N) from the oximes of (purin-9-yl)acetaldehyde or (coumarinyloxy)acetaldehyde with allyloxycoumarins or...
Kamal Shah,Jeetendra K Gupta,Nagendra S Chauhan et al.
Kamal Shah et al.
Intoroduction: Prodrug approach deals with chemical biotransformation or enzymatic conversion or involves inactive or less active bio-reversible derivatives of active drug molecules. They have to pass through enzymatic or...
Huba Kalász,Julianna Thuróczy,Gellért Karvaly et al.
Huba Kalász et al.
Background: Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered. Objective: S...
Molecular Docking, Pharmacophore, and 3D-QSAR Approach: Can Adenine Derivatives Exhibit Significant Inhibitor Towards Ebola Virus? [0.03%]
分子对接、药效团单元及三维定量结构活性关系研究：腺嘌呤衍生物可否作为有效的埃博拉病毒抑制剂？
Amit Rai,Mohamed H Aboumanei,Suraj P Verma et al.
Amit Rai et al.
Introduction: Ebola Virus Disease (EVD) is caused by Ebola virus, which is often accompanied by fatal hemorrhagic fever upon infection in humans. This virus has caused the majority of deaths in human. There are no proper ...
A Review on the Modification of Polysaccharide Through Graft Copolymerization for Various Potential Applications [0.03%]
通过接枝共聚改性多糖用于各种潜在应用的研究进展综述
Deepak Kumar,Jyoti Pandey,Vinit Raj et al.
Deepak Kumar et al.
Introduction: Graft copolymerization is one of the most promising technique uses to modify the properties of naturally available polymers with a minimum loss in their native characteristics. ...
Pyrrolyl Pyrazoline Carbaldehydes as Enoyl-ACP Reductase Inhibitors: Design, Synthesis and Antitubercular Activity [0.03%]
吡咯并吡唑啉甲醛类红合酶抑制剂的设计、合成及抗结核活性研究
Sheshagiri R Dixit,Shrinivas D Joshi,Venkatarao H Kulkarni et al.
Sheshagiri R Dixit et al.
Introduction: In efforts to develop new antitubercular (anti-TB) compounds, herein we describe cytotoxic evaluation of 15 newly synthesized pyrrolyl pyrazoline carbaldehydes. ...