Central amygdala angiotensin type 1 receptor (Agtr1) expressing neurons contribute to fear extinction [0.03%]
中央杏仁核血管紧张素Ⅱ受体1型神经元在恐惧消退中的作用研究
Zhe Yu,Alexandre Kisner,Amy Bhatt et al.
Zhe Yu et al.
The renin-angiotensin system (RAS) has been linked to the pathophysiology of posttraumatic stress disorder (PTSD) however, the underlying neurobiological mechanism(s) remain elusive. Here we utilized angiotensin II receptor type 1 (AT1R) tr...
Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1) [0.03%]
羟基羧酸受体2(HCAR2)在小胶质细胞病理生理中的潜在作用：与C-X-C趋化因子受体1(CXCR1)相互作用的可能性
Michela Perrone,Martina Pagano,Carmela Belardo et al.
Michela Perrone et al.
Following insults or injury, microglia cells are activated contributing to the cytotoxic response or by promoting an immune-mediated damage resolution. Microglia cells express HCA2R, a hydroxy carboxylic acid (HCA) receptor, which has been ...
Chronic intermittent ethanol exposure differentially alters the excitability of neurons in the orbitofrontal cortex and basolateral amygdala that project to the dorsal striatum [0.03%]
慢性间歇性乙醇暴露会改变轨道前额叶皮质和基底外侧杏仁核中背侧纹状体化神经元的兴奋性
Sudarat Nimitvilai-Roberts,Dominic Gioia,Marcelo F Lopez et al.
Sudarat Nimitvilai-Roberts et al.
Alcohol use disorder is associated with altered neuron function including those in orbitofrontal cortex (OFC) and basolateral amygdala (BLA) that send glutamatergic inputs to areas of the dorsal striatum (DS) that mediate goal and habit dir...
PLPP/CIN inhibits dopamine D1 receptor-mediated seizure activity via DARPP-32 serine 97 dephosphorylation in the mouse hippocampus [0.03%]
PLPP/CIN通过在小鼠海马体中DARPP-32丝氨酸去磷酸化抑制多巴胺D₁受体介导的癫痫样活动
Ji-Eun Kim,Duk-Shin Lee,Tae-Hyun Kim et al.
Ji-Eun Kim et al.
Dopamine plays a central role in the regulation of psychomotor functions in the brain. Furthermore, the dopaminergic system is involved in the ictogenesis in human patients and animal models of epilepsy. Dopamine and cAMP-regulated phosphop...
One immune system plays many parts: The dynamic role of the immune system in chronic pain and opioid pharmacology [0.03%]
一个免疫系统扮演多种角色：免疫系统在慢性疼痛和阿片药理学中的动态作用
Sanam Mustafa,Juliana E Bajic,Benjamin Barry et al.
Sanam Mustafa et al.
The transition from acute to chronic pain is an ongoing major problem for individuals, society and healthcare systems around the world. It is clear chronic pain is a complex multidimensional biological challenge plagued with difficulties in...
Neuroimmune interactions with binge alcohol drinking in the cerebellum of IL-6 transgenic mice [0.03%]
白细胞介素-6转基因小鼠脑室内酒精中毒引起的神经免疫相互作用研究
Donna L Gruol,Delilah Calderon,Katharine French et al.
Donna L Gruol et al.
The neuroimmune system of the brain, which is comprised primarily of astrocytes and microglia, regulates a variety of homeostatic mechanisms that underlie normal brain function. Numerous conditions, including alcohol consumption, can disrup...
Distinct populations of corticotropin-releasing factor (CRF) neurons mediate divergent yet complementary defensive behaviors in response to a threat [0.03%]
不同类型的促肾上腺皮质激素释放因子(CRF)神经元在机体应对威胁时发挥不同的作用并相互配合以激发防御行为
Rachel Chudoba,Joanna Dabrowska
Rachel Chudoba
Defensive behaviors in response to a threat are shared across the animal kingdom. Active (fleeing, sheltering) or passive (freezing, avoiding) defensive responses are adaptive and facilitate survival. Selecting appropriate defensive strateg...
Orchestration of innate and conditioned defensive actions by the periaqueductal gray [0.03%]
控制导水管周围灰质的固有和习得性防御行动 orchestration: 指在乐队中演奏乐器时各个乐手配合的过程，这里是用类比的方式表示各种防御行为之间的协调。
Fernando M C V Reis,Dean Mobbs,Newton S Canteras et al.
Fernando M C V Reis et al.
The midbrain periaqueductal gray (PAG) has been recognized for decades as having a central role in the control of a wide variety of defensive responses. Initial discoveries relied primarily on lesions, electrical stimulation and pharmacolog...
Recapitulating phenotypes of alcohol dependence via overexpression of Oprk1 in the ventral tegmental area of non-dependent TH::Cre rats [0.03%]
通过非依赖性TH::Cre大鼠中缝腹侧区Oprk1过表达 Recapitulation酒精依赖表型
Gaetan Lepreux,Grace E Shinn,Gengze Wei et al.
Gaetan Lepreux et al.
The dynorphin (DYN)/kappa-opioid receptor (KOR) system is involved in dysphoria and negative emotional states. Dysregulation of KOR function promotes maladaptive behavioral regulation during withdrawal associated with alcohol dependence. Me...
L-type calcium channel antagonist isradipine age-dependently decreases plaque associated dystrophic neurites in 5XFAD mouse model [0.03%]
L型钙通道拮抗剂伊索拉明在5XFAD小鼠模型中年龄依赖性地减少与斑块相关的退行性神经突触
Jessica L Wickline,Sabrina Smith,Riley Shin et al.
Jessica L Wickline et al.
Epidemiological studies suggest that L-type calcium channel (LTCC) antagonists may reduce the incidence of age-associated neurodegenerative diseases including Alzheimer's disease (AD). However, the neuroprotective mechanism of LTCC antagoni...