Perturbation of maternal gut microbiota in mice during a critical perinatal window influences early neurobehavioral outcomes in offspring [0.03%]
小鼠肠道微生物群在关键的围产期窗口扰动影响后代早期神经行为结局
Cassandre Morel,Ines Martinez Sanchez,Yamina Cherifi et al.
Cassandre Morel et al.
The gut microbiota is increasingly recognized as a key environmental factor that shapes host development and physiology, including neural circuits formation and function. Concurrently, there has been growing concern that early-life antibiot...
Ketamine reduces electrophysiological network activity in cortical neuron cultures already at sub-micromolar concentrations - Impact on TrkB-ERK1/2 signaling [0.03%]
氯胺酮以亚微摩尔浓度抑制皮层神经网络活动及其对TrkB-ERK1/2信号的影响
A Ahtiainen,I Annala,M Rosenholm et al.
A Ahtiainen et al.
The dissociative anesthetic ketamine regulates cortical activity in a dose-dependent manner. Subanesthetic-dose ketamine has paradoxical excitatory effects which is proposed to facilitate brain-derived neurotrophic factor (BDNF) (a ligand o...
Bifidobacterium breve Bif11 supplementation improves depression-related neurobehavioural and neuroinflammatory changes in the mouse [0.03%]
鼠短双歧杆菌Bif11补充改善抑郁相关的神经行为和神经炎症变化
Gunuputi Sushma,Bhupesh Vaidya,Shikha Sharma et al.
Gunuputi Sushma et al.
Gut dysbiosis has been closely linked to the onset and progression of several brain-related disorders such as depression. The administration of microbiota-based formulations such as probiotics helps restore healthy gut flora and plays a rol...
National Institutes of Health psilocybin research speaker series: State of the science, regulatory and policy landscape, research gaps, and opportunities [0.03%]
美国国立卫生研究院迷幻蘑菇裸盖菇素研究演讲系列：科学现状、监管和政策格局、研究缺口及机遇等
Dan Xi,Ann Berger,David Shurtleff et al.
Dan Xi et al.
The U.S. National Institutes of Health (NIH) convened a seminal first ever psychedelic drug substance-focused speaker series, from April 22 to June 10, 2021, titled the "NIH Psilocybin Research Speaker Series." This speaker series provided ...
The expression of agmatinase manipulates the affective state of rats subjected to chronic restraint stress [0.03%]
瓜氨酸酶的表达调控慢性束缚应激大鼠的情感状态
Shi Yan,Chang Xu,Mengli Yang et al.
Shi Yan et al.
Agmatine is an endogenous polyamine produced from l-arginine and degraded by agmatinase (AGMAT). Studies in humans and animals have shown that agmatine has neuroprotective, anxiolytic, and antidepressant-like actions. However, little is kno...
Ulyana Lalo,Yuriy Pankratov
Ulyana Lalo
ATP released from the synaptic terminals and astrocytes can activate neuronal P2 receptors at a variety of locations across the CNS. Although the postsynaptic ATP-mediated signalling does not bring a major contribution into the excitatory t...
Chronic oral ketamine prevents anhedonia and alters neuronal activation in the lateral habenula and nucleus accumbens in rats under chronic unpredictable mild stress [0.03%]
慢性口服氯胺酮可预防慢性轻度不可预测应激大鼠的快感缺失并改变侧缰核和伏隔核神经元活性
Ege Kingir,Cem Sevinc,Gunes Unal
Ege Kingir
Acute injections of ketamine lead to rapid but transient antidepressant effects. Chronic oral treatment at low doses, a promising non-invasive alternative, may prolong this therapeutic effect. Here, we examine the antidepressant effects of ...
Beneficial effects of arketamine on the reduced bone mineral density in susceptible mice after chronic social defeat stress: Role of the gut-microbiota-bone-brain axis [0.03%]
氯胺酮对慢性社交挫败敏感小鼠降低骨密度的影响及肠道微生态系统作用机制研究
Xiayun Wan,Akifumi Eguchi,Lijia Chang et al.
Xiayun Wan et al.
Patients with depression exhibit reduced bone mineral density (BMD). We previously reported that the new antidepressant arketamine improved the reduced BMD seen in chronic social defeat stress (CSDS) susceptible mice and ovariectomized mice...
Salience to remember: VTA-IC dopaminergic pathway activity is necessary for object recognition memory formation [0.03%]
记住凸显度：伏隔核-VTA多巴胺通路活性对于物体识别记忆形成是必要的
Gerardo Ramirez-Mejia,Elvi Gil-Lievana,Oscar Urrego-Morales et al.
Gerardo Ramirez-Mejia et al.
Previous studies have shown that dopaminergic activity modulates the salience of novel stimuli enabling the formation of recognition memories. In this work, we hypothesize that dopamine released into the insular cortex (IC) from the ventral...
Basic metabolic and vascular effects of ketamine and its interaction with fentanyl [0.03%]
氯胺酮的基本代谢和血管效应及其与芬太尼的相互作用
Matthew R Irwin,Carlos M Curay,Shinbe Choi et al.
Matthew R Irwin et al.
Ketamine is a short-acting general anesthetic with hallucinogenic, analgesic, and amnestic properties. In addition to its anesthetic use, ketamine is commonly abused in rave settings. While safe when used by medical professionals, uncontrol...