Corticotropin-releasing factor potentiates glutamatergic input and excitability of presympathetic neurons in the hypothalamus in spontaneously hypertensive rats [0.03%]
下丘脑CRF增强神经元的兴奋性及谷氨酸能输入对SHR前交感神经元的作用
Hongyu Ma,Ziye Cui,Xinqi Guo et al.
Hongyu Ma et al.
Hyperactivity of presympathetic neurons in the hypothalamic paraventricular nucleus (PVN) plays a key role in generating excess sympathetic output in hypertension. However, the mechanisms driving hyperactivity of PVN presympathetic neurons ...
The gut-brain connection: Exploring the influence of the gut microbiota on neuroplasticity and neurodevelopmental disorders [0.03%]
肠-脑联系：探索肠道微生物群对神经可塑性和神经发育障碍的影响
Francesca Damiani,Sara Cornuti,Paola Tognini
Francesca Damiani
Neuroplasticity refers to the ability of brain circuits to reorganize and change the properties of the network, resulting in alterations in brain function and behavior. It is traditionally believed that neuroplasticity is influenced by exte...
Kenneth A Jacobson,Balaram Pradhan,Zhiwei Wen et al.
Kenneth A Jacobson et al.
The discovery and clinical implementation of modulators of adenosine, P2Y and P2X receptors (comprising nineteen subtypes) have progressed dramatically in ∼50 years since Burnstock's definition of purinergic signaling. Although most clinic...
Preclinical perspectives on the mechanisms underlying the therapeutic actions of psilocybin in psychiatric disorders [0.03%]
裸盖菇素治疗精神疾病的潜在作用机制的临床前研究观点
Andreas B Wulff,Charles D Nichols,Scott M Thompson
Andreas B Wulff
Psychedelic compounds have shown extraordinary potential in treating a wide range of neuropsychiatric disorders. Psilocybin, for example, has now been shown in several clinical trials to induce a rapid (within days) and persistent (3-12 mon...
The involvement of dopamine and D2 receptor-mediated transmission in effects of cotinine in male rats [0.03%]
尼古丁在大鼠体内发挥效果时多巴胺及D2受体介导的信号传输的作用
Xiaoying Tan,Elizabeth M Neslund,Zheng-Ming Ding
Xiaoying Tan
Previous studies indicated that cotinine, the major metabolite of nicotine, supported intravenous self-administration and exhibited relapse-like drug-seeking behaviors in rats. Subsequent studies started to reveal an important role of the m...
Oxytocin treatments or activation of the paraventricular nucleus-the shell of nucleus accumbens pathway reduce adverse effects of chronic social defeat stress on emotional and social behaviors in Mandarin voles [0.03%]
oxytocin治疗或下丘脑室旁核-伏隔核壳核通路的激活可改善纹状绒鼠慢性社会挫败应激后的不良情绪和社会行为效应
Wenjuan Hou,Shuying Huang,Lu Li et al.
Wenjuan Hou et al.
Chronic social stress can cause psychological disease. Although oxytocin (OT) has been showed to modulate effects of chronic social defeat stress (CSDS) on emotional and social behaviors, however, how OT circuits mediate effects of CSDS on ...
Ketamine and its metabolites: Potential as novel treatments for depression [0.03%]
氯胺酮及其代谢产物作为新型抗抑郁药物的潜能
Kenji Hashimoto,Shigeyuki Chaki
Kenji Hashimoto
Intermittent cocaine self-administration has sex-specific effects on addiction-like behaviors in rats [0.03%]
间断式可卡因自给行为具有性别特异性成瘾行为效应
Brooke N Bender,Mary M Torregrossa
Brooke N Bender
Intermittent access (IntA) models of cocaine self-administration were developed to better model in rodents how cocaine is used by human drug users. Compared to traditional continuous access (ContA) models, IntA has been shown to enhance sev...
Somdatta Saha,Javier González-Maeso
Somdatta Saha
Schizophrenia is a severe brain disorder that usually produces a lifetime of disability. First generation or typical antipsychotics such as haloperidol and second generation or atypical antipsychotics such as clozapine and risperidone remai...
Gudimetla Susmitha,Rahul Kumar
Gudimetla Susmitha
Alzheimer's disease (AD) is the leading cause of dementia in the elderly and detected during the advanced stages where the chances of reversal are minimum. The gut-brain axis mediates a bidirectional communication between the gut and brain,...