Functional crosstalk of the glycine transporter GlyT1 and NMDA receptors [0.03%]
甘氨酸转运蛋白GlyT1与N-甲基-D天冬氨酸受体的功能互作关系
Dolores Piniella,Francisco Zafra
Dolores Piniella
NMDA-type glutamate receptors (NMDARs) constitute one of the main glutamate (Glu) targets in the central nervous system and are involved in synaptic plasticity, which is the molecular substrate of learning and memory. Hypofunction of NMDARs...
KNT-127, a selective delta opioid receptor agonist, shows beneficial effects in the hippocampal dentate gyrus of a chronic vicarious social defeat stress mouse model [0.03%]
选择性δ阿片受体激动剂KNT-127对慢性代理社会挫败应激小鼠海马齿状回的有益作用
Toshinori Yoshioka,Daisuke Yamada,Eri Segi-Nishida et al.
Toshinori Yoshioka et al.
Delta opioid receptors (DOPs) play an important role in depression and other mood disorders. However, little is known about the underlying physiological mechanisms. The hypothalamic-pituitary-adrenal axis, adult hippocampal neurogenesis, an...
A novel monobactam lacking antimicrobial activity, MC-100093, reduces sex-specific ethanol preference and depressive-like behaviors in mice [0.03%]
一种新型无抗菌活性的单环β-内酰胺抗生素MC-100093能够降低小鼠性别特异性的酒精偏好和抑郁样行为
Brandon Emanuel León,Lee Peyton,Hesham Essa et al.
Brandon Emanuel León et al.
Several β-lactam derivatives upregulate astrocytic glutamate transporter type 1expression and are known to improve measures in models of mood and alcohol use disorders (AUD) through normalizing glutamatergic states. However, long-term, and...
Sudden unexpected death in epilepsy is prevented by blocking postictal hypoxia [0.03%]
通过阻断癫痫发作后的低氧来预防由癫痫引起的突发意外死亡
Antis G George,Jordan S Farrell,Roberto Colangeli et al.
Antis G George et al.
Epilepsy is at times a fatal disease. Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality in people with intractable epilepsy and is defined by exclusion; non-accidental, non-toxicologic, and non-a...
Chronic inflammatory pain promotes place preference for fentanyl in male rats but does not change fentanyl self-administration in male and female rats [0.03%]
慢性炎症疼痛促进雄性大鼠对芬太尼的地点偏好但不影响雌雄大鼠对芬太尼的自我给药行为
Angela E Barattini,Christian Montanari,Kimberly N Edwards et al.
Angela E Barattini et al.
The current opioid epidemic is a national health crisis marked by skyrocketing reports of opioid misuse and overdose deaths. Despite the risks involved, prescription opioid analgesics are the most powerful and effective medications for trea...
Volker Neugebauer,Peyton Presto,Vadim Yakhnitsa et al.
Volker Neugebauer et al.
Neuroplasticity in cortico-limbic circuits has been implicated in pain persistence and pain modulation in clinical and preclinical studies. The amygdala has emerged as a key player in the emotional-affective dimension of pain and pain modul...
The pattern of brain oxygen response induced by intravenous fentanyl limits the time window of therapeutic efficacy of naloxone [0.03%]
脑氧应激状态下静脉注射芬太尼引起的脑氧反应模式限制了纳洛酮的治疗时间窗口大小
Carlos M Curay,Matthew R Irwin,Eugene A Kiyatkin
Carlos M Curay
Opioids induce respiratory depression resulting in coma or even death during overdose. Naloxone, an opioid antagonist, is the gold standard reversal agent for opioid intoxication, but this treatment is often less successful for fentanyl. Wh...
Selective PDE4B and PDE4D inhibitors produce distinct behavioral responses to ethanol and GABAergic drugs in mice [0.03%]
选择性PDE4B和PDE4D抑制剂产生对小鼠乙醇和GABA能药物的行为反应
Yuri A Blednov,Adriana Da Costa,Sonia Mason et al.
Yuri A Blednov et al.
Apremilast is a phosphodiesterase (PDE) type 4 inhibitor that is nonselective at subtypes PDE4A-D. It modulates ethanol and GABAergic responses via protein kinase A (PKA) phosphorylation of specific GABAA receptor subunits and has opposite ...
Receptor-receptor interactions and microvesicle exchange as mechanisms modulating signaling between neurons and astrocytes [0.03%]
受体-受体相互作用和微囊交换在调节神经元与星形胶质细胞信号转导中的机制作用
Diego Guidolin,Cinzia Tortorella,Manuela Marcoli et al.
Diego Guidolin et al.
It is well known that astrocytes play a significant metabolic role in the nervous tissue, maintaining the homeostasis of the extracellular space and of the blood-brain barrier, and providing trophic support to neurons. In addition, however,...
The role of IL-23/IL-17 axis in ischemic stroke from the perspective of gut-brain axis [0.03%]
肠道微生物组-肠-脑轴介导的缺血性卒中中的IL-23/IL-17信号通路机制及其作用研究进展
Yang Jiang,Yajie Dai,Zhenquan Liu et al.
Yang Jiang et al.
Bidirectional communication between central nervous system (CNS) and intestine is mediated by nerve, endocrine, immune and other pathways in gut-brain axis. Many diseases of CNS disturb the homeostasis of intestine and gut microbiota. Simil...