Neurotensin receptor 1-biased ligand attenuates neurotensin-mediated excitation of ventral tegmental area dopamine neurons and dopamine release in the nucleus accumbens [0.03%]
神经紧张素受体1偏向性配体通过减弱神经紧张素诱发的腹侧被盖区多巴胺能神经元兴奋及纹状体内多巴胺释放来缓解精神分裂症症状
Sarthak M Singhal,Vivien Zell,Lauren Faget et al.
Sarthak M Singhal et al.
Strong expression of the G protein-coupled receptor (GPCR) neurotensin receptor 1 (NTR1) in ventral tegmental area (VTA) dopamine (DA) neurons and terminals makes it an attractive target to modulate DA neuron activity and normalize DA-relat...
Neurosteroids as positive and negative allosteric modulators of ligand-gated ion channels: P2X receptor perspective [0.03%]
神经类固醇作为离子门控受体的正负别构调节剂的作用:P2X受体的新视角
Sonja Sivcev,Eva Kudova,Hana Zemkova
Sonja Sivcev
Neurosteroids are steroids synthesized de novo in the brain from cholesterol in an independent manner from peripheral steroid sources. The term "neuroactive steroid" includes all steroids independent of their origin, and newly synthesized a...
Pre- and postsynaptic modulation of hippocampal inhibitory synaptic transmission by pregnenolone sulphate [0.03%]
孕烯醇龙硫酸盐对海马抑制性突触传递的上行和下行调控作用
Sandra Seljeset,Seth Liebowitz,Damian P Bright et al.
Sandra Seljeset et al.
Neurosteroids are important endogenous modulators of GABAA receptor-mediated neurotransmission within the CNS and play a vital role in maintaining normal healthy brain function. Research has mainly focussed on neurosteroids such as allopreg...
Contextual fear expression engages a complex set of interactions between ventromedial prefrontal cortex cholinergic, glutamatergic, nitrergic and cannabinergic signaling [0.03%]
腹内侧前额叶皮层胆碱能、谷氨酸能、一氧化氮和大麻素信号通路的相互作用参与了恐惧表达
Daniela Lescano Uliana,Cassiano Ricardo Alves Faria Diniz,Leandro Antero da Silva et al.
Daniela Lescano Uliana et al.
Rats re-exposed to an environment previously associated with the onset of shocks evoke a set of conditioned defensive responses in preparation to an eventual flight or fight reaction. Ventromedial prefrontal cortex (vmPFC) is mutually impor...
Are psychedelic medicines the reset for chronic pain? Preliminary findings and research needs [0.03%]
迷幻药物是慢性疼痛的解决方案吗？初步研究结果和未来研究方向
Farah Z Zia,Michael H Baumann,Sean J Belouin et al.
Farah Z Zia et al.
Chronic pain is a leading cause of disability, reduced productivity, healthcare seeking behavior, and a contributor to opioid overdose in the United States. For many people, pain can be satisfactorily managed by existing medicines and compr...
Alcohol potentiates multiple GABAergic inputs to dorsal striatum fast-spiking interneurons [0.03%]
酒精增强到背侧纹状体快发放中间神经元的多种GABA能输入信号
Michael S Patton,Samuel H Sheats,Allison N Siclair et al.
Michael S Patton et al.
Parvalbumin-expressing dorsal striatal fast-spiking interneurons, comprising ∼1% of the total dorsal striatal neuronal population, are necessary for the expression of compulsive-like ethanol consumption mice. Fast-spiking interneurons are ...
Receptor expression and signaling properties in the brain, and structural ligand motifs that contribute to delta opioid receptor agonist-induced seizures [0.03%]
大脑中的受体表达和信号转导特性以及贡献于δ型阿片受体激动剂致惊厥的结构配体基序
Arryn T Blaine,Richard M van Rijn
Arryn T Blaine
The δ opioid receptor (δOR) is a therapeutic target for the treatment of various neurological disorders, such as migraines, chronic pain, alcohol use, and mood disorders. Relative to μ opioid receptor agonists, δOR agonists show lower a...
An inhibitor with GSK3β and DYRK1A dual inhibitory properties reduces Tau hyperphosphorylation and ameliorates disease in models of Alzheimer's disease [0.03%]
一种GSK3β和DYRK1A双靶点抑制剂可降低Tau过度磷酸化并改善阿尔茨海默病模型小鼠的认知缺陷
Xin Liu,Ling-Yun Lai,Jiang-Xia Chen et al.
Xin Liu et al.
Since Alzheimer's disease (AD) is a complex and multifactorial neuropathology, the discovery of multi-targeted inhibitors has gradually demonstrated greater therapeutic potential. Neurofibrillary tangles (NFTs), the main neuropathologic hal...
From recent advances in underlying neurocircuitry of fear and anxiety to promising pharmacotherapies for PTSD: The saga of heart, sex and the developing brain [0.03%]
从恐惧和焦虑的神经环路研究新进展到PTSD有希望的药物治疗：来自心脏，性以及发育中的大脑的故事
Joanna Dabrowska
Joanna Dabrowska
Available pharmacotherapies for anxiety disorders and post-traumatic stress-disorder (PTSD) have limited efficacy, but no new anxiolytic drug has been approved for treatment since the 1980s. In this issue of Neuropharmacology on "Fear, anxi...
Advances in the characterization of negative affect caused by acute and protracted opioid withdrawal using animal models [0.03%]
利用动物模型表征急性阿片类药物脱毒和持续性阿片类药物脱毒引起负面情绪的进展
Dersu Ozdemir,Florence Allain,Brigitte L Kieffer et al.
Dersu Ozdemir et al.
Opioid use disorder (OUD) is a chronic brain disease which originates from long-term neuroadaptations that develop after repeated opioid consumption and withdrawal episodes. These neuroadaptations lead among other things to the development ...