Quinpirole, but not muscimol, infused into the nucleus accumbens disrupts prepulse inhibition of the acoustic startle in rhesus macaques [0.03%]
昆普瑞林而非蘑菇碱作用于伏隔核能破坏恒河猴听性惊跳的prepulse抑制作用
Hannah F Waguespack,Rafael S Maior,Carolina Campos-Rodriguez et al.
Hannah F Waguespack et al.
Sensorimotor gating is the ability to suppress motor responses to irrelevant sensory inputs. This response is disrupted in a range of neuropsychiatric disorders. Prepulse inhibition (PPI) of the acoustic startle response (ASR) is a form of ...
Thatiane De Oliveira Sergio,Sarah Wean,Simon N Katner et al.
Thatiane De Oliveira Sergio et al.
Alcohol Use Disorders (AUD) is characterized by compulsion-like alcohol drinking (CLAD), where intake despite negative consequences can be a major clinical obstacle. With few treatment options available for AUD, there is a significant need ...
Characterizing the metabolomic signature of attention-deficit hyperactivity disorder in twins [0.03%]
双胞胎注意缺陷多动障碍代谢标志的特征分析
J R Swann,R Diaz Heijtz,J Mayneris-Perxachs et al.
J R Swann et al.
Emerging evidence implicate the gut microbiota as a potential susceptibility factor in attention-deficit hyperactivity disorder (ADHD), a common multifactorial neurodevelopmental condition. However, little is known about the biochemical sig...
Systemic treatment with GnRH agonist produces antidepressant-like effects in LPS induced depression male mouse model [0.03%]
促性腺激素释放素激动剂的全身治疗可产生类似抗抑郁的作用效应于LPS诱导的小鼠抑郁模型中
Yang Xu,Wei Li,Mengmeng Shi et al.
Yang Xu et al.
Gonadotropin-releasing hormone (GnRH) is at the head of the neuroendocrine reproductive axis. However, the non-reproductive functions of GnRH expressed in various tissues, including hippocampus, are still not known. Here, we unveil a previo...
Cannabidiol regulates behavioral and brain alterations induced by spontaneous alcohol withdrawal [0.03%]
大麻二酚调节自发性酒精戒断引起的脑和行为改变
Ani Gasparyan,Francisco Navarrete,Daniela Navarro et al.
Ani Gasparyan et al.
The main goal of this study was to evaluate if the administration of cannabidiol (CBD) regulates behavioral and gene expression alterations induced by spontaneous alcohol withdrawal (SAW) in mice. Increasing doses of ethanol were administer...
Activating the dorsomedial and ventral midbrain projections to the striatum differentially impairs goal-directed action in male mice [0.03%]
激活纹状体背内侧和中脑腹侧投射分别阻碍小鼠有目标的动作完成
Kyna-Anne Conn,Simin Zou,Joyosmita Das et al.
Kyna-Anne Conn et al.
The cognitive symptoms of schizophrenia are wide ranging and include impaired goal-directed action. This could be driven by an increase in dopamine transmission in the dorsomedial striatum, a pathophysiological hallmark of schizophrenia. Al...
Endocannabinoid-dependent decrease of GABAergic transmission on dopaminergic neurons is associated with susceptibility to cocaine stimulant effects in pre-adolescent male MAOA hypomorphic mice exposed to early life stress [0.03%]
与早年生活压力暴露的MAOA低等位基因型小鼠易感可卡因兴奋效应相关的内源大麻素介导的多巴胺能神经元上GABA能传递降低的现象
Valeria Serra,Sonia Aroni,Marco Bortolato et al.
Valeria Serra et al.
Vulnerability to cocaine use disorder depends upon a combination of genetic and environmental risk factors. While early life adversity is a critical environmental vulnerability factor for drug misuse, allelic variants of the monoamine oxida...
Preclinical evidence for the use of the atypical antipsychotic, brexpiprazole, for opioid use disorder [0.03%]
非典型抗精神病药brexpiprazole治疗阿片类药物使用障碍的临床前证据
Julia E R Nickols,Serdar M Dursun,Anna M W Taylor
Julia E R Nickols
Opioid addiction is characterized by adaptations in the mesolimbic dopamine system that occur during chronic opioid use. Alterations in dopaminergic transmission contribute to pathological drug-seeking behavior and other symptoms associated...
P2 receptor-mediated signaling in the physiological and pathological brain: From development to aging and disease [0.03%]
生理和病理条件下脑内P2受体介导的信号转导：从发育到衰老及疾病
Paula Mut-Arbona,Beáta Sperlágh
Paula Mut-Arbona
The purinergic pathway mediates both pro-inflammatory and anti-inflammatory responses, whereas the breakdown of adenosine triphosphate (ATP) is in a critical equilibrium. Under physiological conditions, extracellular ATP is maintained at a ...
Acceleration of GABA-switch after early life stress changes mouse prefrontal glutamatergic transmission [0.03%]
早期生活压力加速GABA转换影响小鼠前额叶谷氨酸能传递
Henk Karst,Wouter J Droogers,Nelleke van der Weerd et al.
Henk Karst et al.
Early life stress (ELS) alters the excitation-inhibition-balance (EI-balance) in various rodent brain areas and may be responsible for behavioral impairment later in life. The EI-balance is (amongst others) influenced by the switch of GABAe...