Yuan Chang-Halabi,José Cordero,Xander Sarabia et al.
Yuan Chang-Halabi et al.
Ionotropic receptors are ligand-gated ion channels triggering fast neurotransmitter responses. Among them, P2X and 5-HT3 receptors have been shown to physically interact each other and functionally inducing cross inhibitory responses. Never...
Differences in the gut microbiome across typical ageing and in Parkinson's disease [0.03%]
正常老化与帕金森病的肠道微生物组差异
Nathan D Nuzum,Ewa A Szymlek-Gay,Stella Loke et al.
Nathan D Nuzum et al.
The microbiota-gut-brain axis' role in Parkinson's disease (PD) pathophysiology, and how this differs from typical ageing, is poorly understood. Presently, gut-bacterial diversity, taxonomic abundance and metabolic bacterial pathways were c...
Live or heat-killed probiotic administration reduces anxiety and central cytokine expression in BALB/c mice, but differentially alters brain neurotransmitter gene expression [0.03%]
益生菌的活菌或死菌制剂均可减少BALB/C小鼠的焦虑及中枢细胞因子表达，但会以不同的方式改变大脑中神经递质基因的表达
Ka Wai Chan,Jennifer Hebert,Daniel Radford-Smith et al.
Ka Wai Chan et al.
While the potential for probiotic supplements to act as adjunctive treatments for mood disorders has been widely demonstrated, the precise mode of action remains unclear. To investigate the psychotropic effects of a multi-species probiotic ...
Intermittent-access operant alcohol self-administration promotes binge-like drinking and drinking despite negative consequences in male and female heterogeneous stock rats [0.03%]
间歇性操作性酒精自给促进雄性和雌性杂种大鼠醉酒和后果不顾饮酒行为
Grey A Gage,Marissa A Muench,Changhoon Jee et al.
Grey A Gage et al.
The study of Alcohol Use Disorders (AUD) in preclinical models is hampered by difficulty in training rodents to voluntarily consume high levels of alcohol. The intermittency of alcohol access/exposure is well known to modulate alcohol consu...
Enhancement of memory consolidation by an avoidance conditioned stimulus: Modulation by the D3 receptor [0.03%]
通过D3受体调节的回避条件刺激对巩固的加强作用
Thomas Lapointe,Travis Francis,Kamrani Doray et al.
Thomas Lapointe et al.
Conditioned stimuli (CS) paired with foot-shock can enhance memory consolidation. Because the dopamine D3 receptor (D3R) has been implicated in mediating various responses to CSs, the current study explored its potential role in modulation ...
PirB negatively regulates the inflammatory activation of astrocytes in a mouse model of sleep deprivation [0.03%]
PirB在睡眠剥夺小鼠模型中通过负向调节星形胶质细胞的炎症活化发挥作用
Liya Li,Yan Mou,Qian Zhai et al.
Liya Li et al.
Reactive astrocytes play a potential regulatory role in sleep deprivation (SD). Paired immunoglobulin-like receptor B (PirB) is expressed in reactive astrocytes, suggesting that PirB may participate in regulating the inflammatory response o...
Metamodulation of presynaptic NMDA receptors: New perspectives for pharmacological interventions [0.03%]
突触前N-甲基-D天冬氨酸受体的跨调控：药物干预的新视角
Guendalina Olivero,Massimo Grilli,Mario Marchi et al.
Guendalina Olivero et al.
Metamodulation shifted the scenario of the central neuromodulation from a simplified unimodal model to a multimodal one. It involves different receptors/membrane proteins physically associated or merely colocalized that act in concert to co...
GPCR interactions involving metabotropic glutamate receptors and their relevance to the pathophysiology and treatment of CNS disorders [0.03%]
代谢型谷氨酸受体的G蛋白偶联受体相互作用及其在中枢神经系统疾病病理生理和治疗中的相关性
Ferdinando Nicoletti,Luisa Di Menna,Luisa Iacovelli et al.
Ferdinando Nicoletti et al.
Cellular responses to metabotropic glutamate (mGlu) receptor activation are shaped by mechanisms of receptor-receptor interaction. mGlu receptor subtypes form homodimers, intra- or inter-group heterodimers, and heteromeric complexes with ot...
Adolescent binge drinking leads to long-lasting changes in cortical microcircuits in mice [0.03%]
青春期大量饮酒会导致小鼠皮质微回路发生持久性变化
Avery R Sicher,William D Starnes,Keith R Griffith et al.
Avery R Sicher et al.
Adolescent drug consumption has increased risks to the individual compared to consumption in adulthood, due to the likelihood of long-term and permanent behavioral and neurological adaptations. However, little is known about how adolescent ...
CHRNA5 gene variation affects the response of VTA dopaminergic neurons during chronic nicotine exposure and withdrawal [0.03%]
CHRNA5基因多态性影响尼古丁慢性暴露及戒断对中脑伏隔核多巴胺神经元的作用
Kechun Yang,Ian McLaughlin,Jessica K Shaw et al.
Kechun Yang et al.
Nicotine is the principal psychoactive component in tobacco that drives addiction through its action on neuronal nicotinic acetylcholine receptors (nAChR). The nicotinic receptor gene CHRNA5, which encodes the α5 subunit, is associated wit...