GLP-1R knockdown abrogates the protective effects of liraglutide on ischaemic stroke via inhibition of M2 polarisation and activation of NLRP3 inflammasome by reducing Nrf2 activation [0.03%]
通过抑制Nrf2激活而减少M2极化和激活NLRP3炎性小体GLP-1R敲低消除利拉鲁肽对缺血性卒中的保护作用
Xian-Kun Tu,Ping-Ping Chen,Jing-Yi Chen et al.
Xian-Kun Tu et al.
Liraglutide has been recently discovered to penetrate the blood-brain barrier to exert neuroprotective effects. However, relevant mechanisms of the protective effects of liraglutide on ischaemic stroke remain to be elucidated. This study ex...
Serotonin modulates social responses to stressed conspecifics via insular 5-HT2C receptors in rat [0.03%]
五羟色胺通过大鼠脑岛的5-ht2c受体调节对处于压力状态的同类的社会反应
Alexandra J Ng,Lindsay K Vincelette,Jiayi Li et al.
Alexandra J Ng et al.
Behaviors associated with distress can affect the anxiety-like states in observers and this social transfer of affect shapes social interactions among stressed individuals. We hypothesized that social reactions to stressed individuals engag...
Trimethoxyflavanone relieves Paclitaxel-induced neuropathic pain via inhibiting expression and activation of P2X7 and production of CGRP in mice [0.03%]
藤黄素通过抑制P2X7表达和活化及降钙素基因相关肽的产生缓解紫杉醇诱导的神经病理性疼痛小鼠模型的症状
Changqing Mei,Chen Pan,Linbin Xu et al.
Changqing Mei et al.
Paclitaxel (PTX) is an anticancer drug used to treat solid tumors, but one of its common adverse effects is chemotherapy-induced peripheral neuropathy (CIPN). Currently, there is limited understanding of neuropathic pain associated with CIP...
Adjusting the brakes to adjust neuronal activity: Adenosinergic modulation of GABAergic transmission [0.03%]
调节制动以调整神经元活性：腺苷能调节GABA能传递
Ana M Sebastião,Joaquim Alexandre Ribeiro
Ana M Sebastião
About 50 years elapsed from the publication of the first full paper on the neuromodulatory action of adenosine at a 'simple' synapse model, the neuromuscular junction (Ginsborg and Hirst, 1972). In that study adenosine was used as a tool to...
Impaired cognitive control after moderate prenatal alcohol exposure corresponds to altered EEG power during a rodent touchscreen continuous performance task [0.03%]
中度孕期酒精暴露后认知控制受损与触屏连续性能任务期间的改变的EEG功率有关
Sarah L Olguin,James F Cavanagh,Jared W Young et al.
Sarah L Olguin et al.
Although it is well established that alcohol consumption during pregnancy can lead to lifelong difficulties in offspring, Fetal Alcohol Spectrum Disorders (FASD) remain a common neurodevelopmental syndrome. Translational behavioral tools th...
Repetitive transcranial magnetic stimulation and fluoxetine reverse depressive-like behavior but with differential effects on Olig2-positive cells in chronically stressed mice [0.03%]
重复经颅磁刺激和氟西汀逆转慢性压力小鼠的抑郁样行为，但对Olig2阳性细胞的影响不同
Gerardo Bernabé Ramírez-Rodríguez,David Meneses San-Juan,Allan Irasek Rico-Becerra et al.
Gerardo Bernabé Ramírez-Rodríguez et al.
Depression is a mood disorder coursing with several behavioral, cellular, and neurochemical alterations. The negative impact of chronic stress may precipitate this neuropsychiatric disorder. Interestingly, downregulation of oligodendrocyte-...
Lactoferrin averts neurological and behavioral impairments of thioacetamide-induced hepatic encephalopathy in rats via modulating HGMB1/TLR-4/MyD88/Nrf2 pathway [0.03%]
乳铁蛋白通过调节HGMB1/TLR-4/MyD88/Nrf2信号通路来逆转硫乙酸胺致大鼠肝性脑病的神经行为缺陷作用
Reham M Essam,Mariam A Saadawy,Mahitab Gamal et al.
Reham M Essam et al.
Hepatic encephalopathy (HE) is a life-threatening disease caused by acute or chronic liver failure manifested by aberrant CNS changes. In the present study, we aimed to explore the neuroprotective effect of lactoferrin (LF) against thioacet...
Kanamycin treatment in the pre-symptomatic stage of a Drosophila PD model prevents the onset of non-motor alterations [0.03%]
卡那霉素在果蝇PD模型前症状期的治疗阻止了非运动功能障碍的发生
D Molina-Mateo,B P Valderrama,R V Zárate et al.
D Molina-Mateo et al.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor alterations, which is preceded by a prodromal stage where non-motor symptoms are observed. Over recent years, it has become evident that this disorder involves ...
Microbiome and immuno-metabolic dysregulation in patients with major depressive disorder with atypical clinical presentation [0.03%]
以典型临床表现为特征的抑郁症患者中的微生物组和免疫代谢失调
Alexander Refisch,Zümrüt Duygu Sen,Tilman E Klassert et al.
Alexander Refisch et al.
Depression is highly prevalent (6% 1-year prevalence) and is the second leading cause of disability worldwide. Available treatment options for depression are far from optimal, with response rates only around 50%. This is most likely related...
Oxytocinergic neurons, but not oxytocin, are crucial for male penile erection [0.03%]
oxytocin能促进男性阴茎勃起，但并非必要条件
Yu-Xiang Wen,Lin-Yao Fan,An-Yong Yang et al.
Yu-Xiang Wen et al.
The cumulative evidence suggests that oxytocin is involved in the male sexual behaviors. However, no significant sexual impairments were observed in oxytocin gene knock-out (KO) mice, suggesting that oxytocin is not necessary for sexual beh...