Somatostatin signaling modulates binge drinking behavior via the central nucleus of the amygdala [0.03%]
生长抑素通过杏仁中央核调节强迫性饮酒行为
Stacey L Robinson,Todd E Thiele
Stacey L Robinson
Somatostatin (SST) is a neuropeptide widely expressed in the central nervous system with dense expression in limbic regions such as the extended amygdala. It has recently gained attention for playing a role in modulating alcohol use disorde...
Serotonergic circuit dysregulation underlying autism-related phenotypes in BTBR mouse model of autism [0.03%]
五羟色胺能神经环路功能异常介导自闭症模型BTBR小鼠的核心症状
Yuki Higuchi,Tomoaki Tada,Taiga Nakachi et al.
Yuki Higuchi et al.
The inbred mouse strain, BTBR T+Itpr3tf/J (BTBR), possesses neuronal and circuit abnormalities that underlie atypical behavioral profiles resembling the major symptoms of human autism spectrum disorder (ASD). Forebrain serotonin (5-HT) tran...
Linking input- and cell-type-specific synaptic plasticity to the reinforcement of alcohol-seeking behavior [0.03%]
将特异型突触可塑性与酒精寻求行为的强化相联系
Xueyi Xie,Jiayi Lu,Tengfei Ma et al.
Xueyi Xie et al.
The reinforcement of voluntary alcohol-seeking behavior requires dopamine-dependent long-term synaptic plasticity in the striatum. Specifically, the long-term potentiation (LTP) of direct-pathway medium spiny neurons (dMSNs) in the dorsomed...
Disease-modifying effects of cannabidiol, β-caryophyllene and their combination in Syn1-Cre/Scn1aWT/A1783V mice, a preclinical model of Dravet syndrome [0.03%]
大麻二酚、百里香醇及其组合在Dravet综合征近端模型Syn1-Cre/Scn1aWT/A1783V小鼠中的疾病修正作用
Cristina Alonso,Valentina Satta,Inés Hernández-Fisac et al.
Cristina Alonso et al.
Cannabidiol (CBD) has been recently approved as an antiseizure agent in Dravet Syndrome (DS), a pediatric epileptic encephalopathy, but CBD could also be active against associated comorbidities. Such associated comorbidities were also atten...
Conditional deletion of CB2 cannabinoid receptors from peripheral sensory neurons eliminates CB2-mediated antinociceptive efficacy in a mouse model of carrageenan-induced inflammatory pain [0.03%]
条件性删除外周感觉神经元的CB2型大麻素受体可消除CB2介导的卡琼胶诱导的炎性痛小鼠模型中的镇痛效力
Kelsey G Guenther,Zhili Xu,Julian Romero et al.
Kelsey G Guenther et al.
CB2 cannabinoid receptor agonists suppress pathological pain in animal models and lack unwanted side effects commonly associated with direct activation of CB1 receptors. However, the types of pain most responsive to CB2 agonists are incompl...
Modulation of dopamine from ventral tegmental area neurons by the LC-REM-OFF and PPT-REM-ON neurons in REMS regulation in freely moving rats [0.03%]
大鼠快速眼动睡眠调控中蓝斑去甲肾上腺素神经元和脑桥肽能胆碱乙酰转移酶神经元对伏隔核多巴胺的调节作用
Deshdeepak Ratna,Amal Chandra Mondal,Birendra Nath Mallick
Deshdeepak Ratna
The role of dopamine (DA)-ergic neurons in ventral tegmental area (VTA) in schizophrenia, depression, hallucinations have been extensively studied. Rapid eye movement sleep (REMS), the closest objective correlate of dream and hallucination,...
Cell-type specific molecular architecture for mu opioid receptor function in pain and addiction circuits [0.03%]
疼痛和成瘾环路中μ型阿片受体功能的细胞类型特异性分子架构
Nicole E Ochandarena,Jesse K Niehaus,Adrien Tassou et al.
Nicole E Ochandarena et al.
Opioids are potent analgesics broadly used for pain management; however, they can produce dangerous side effects including addiction and respiratory depression. These harmful effects have led to an epidemic of opioid abuse and overdose deat...
Long-term α5 GABA A receptor negative allosteric modulator treatment reduces NMDAR-mediated neuronal excitation and maintains basal neuronal inhibition [0.03%]
长期α5-GABAA受体负性变构调节剂治疗可减少N-甲基-D天冬氨酸受体介导的神经元兴奋并维持基础神经元抑制作用
Jessica L Nuwer,Nadya Povysheva,Tija C Jacob
Jessica L Nuwer
α5 subunit-containing GABA type-A receptors (α5 GABAARs) are enriched in the hippocampus and play critical roles in neurodevelopment, synaptic plasticity, and cognition. α5 GABAAR preferring negative allosteric modulators (α5 NAMs) show...
Tamara Bahamonde,Daisy Quintana-Donoso,Sergio Linsambarth et al.
Tamara Bahamonde et al.
Increased activity in the insula has been consistently reported to be associated with anxiety and anxiety-related disorders. However, little is known on how the insula regulates anxiety. The present study aims at determining the role of the...
D J Heal,S L Smith,S J Belouin et al.
D J Heal et al.
This Special Issue of Neuropharmacology on psychedelics provides a timely and comprehensive update on progress following the previous Neuropharmacology Special Issue "Psychedelics: New Doors, Altered Perceptions". Remarkable advances have b...