Uncovering CNS access of lipidated exendin-4 analogues by quantitative whole-brain 3D light sheet imaging [0.03%]
利用定量全脑三维光片成像揭示脂肪化葛兰明激素类似物的中枢神经系统通路
Grethe Skovbjerg,Urmas Roostalu,Casper G Salinas et al.
Grethe Skovbjerg et al.
Peptide-based drug development for CNS disorders is challenged by poor blood-brain barrier (BBB) penetrability of peptides. While acylation protractions (lipidation) have been successfully applied to increase circulating half-life of therap...
Pre-traumatic antibiotic-induced microbial depletion reduces neuroinflammation in acute murine traumatic brain injury [0.03%]
伤前抗生素诱导的微生物耗竭减少小鼠急性创伤性脑损伤的神经炎症
Katharina Ritter,Diana Vetter,Isa Wernersbach et al.
Katharina Ritter et al.
The connection between dysbiosis of the gut microbiome and diseases and injuries of the brain has attracted considerable interest in recent years. Interestingly, antibiotic-induced microbial dysbiosis has been implicated in the pathogenesis...
Pharmacological GHSR (ghrelin receptor) blockade reduces alcohol binge-like drinking in male and female mice [0.03%]
药物阻断GHSR（生长激素分泌促进素受体）可减少雄性和雌性小鼠的狂饮行为
Rani S Richardson,Agnieszka Sulima,Kenner C Rice et al.
Rani S Richardson et al.
Ghrelin is a peptide that is produced by endocrine cells that are primarily localized in the stomach. Ghrelin receptors (GHSR) are expressed in the brain and periphery. Preclinical and clinical studies support a role for ghrelin in alcohol ...
Complement C1q drives microglia-dependent synaptic loss and cognitive impairments in a mouse model of lipopolysaccharide-induced neuroinflammation [0.03%]
补体C1q驱动小胶质细胞依赖性突触丢失和脂多糖诱导的神经炎症小鼠模型中的认知障碍
Xinmiao Wu,Yuzhu Gao,Cuina Shi et al.
Xinmiao Wu et al.
Activated microglia and subsequent release of pro-inflammatory cytokines result in neuroinflammatory status which further damage neurological function including cognitive impairments in various neurological conditions. However, the underlyi...
Role of purines in brain development, from neuronal proliferation to synaptic refinement [0.03%]
嘌呤在脑发育中的作用：从神经元增殖到突触精细调节
Solen Rimbert,João B Moreira,Sara Xapelli et al.
Solen Rimbert et al.
The purinergic system includes P1 and P2 receptors, which are activated by ATP and its metabolites. They are expressed in adult neuronal and glial cells and are crucial in brain function, including neuromodulation and neuronal signaling. As...
Progress in metamodulation and receptor-receptor interaction: From physiology to pathology and therapy [0.03%]
门控调制与受体-受体相互作用研究进展：从生理到病理和治疗
Anna Pittaluga,Massimo Grilli,Guendalina Olivero
Anna Pittaluga
The organization and the role of receptor-receptor interaction (RRI) and metamodulation in physiological conditions have been extensively analyzed and discussed. In this Special Issue of Neuropharmacology, we review recent advances in the u...
Strain and sex-related behavioral variability of oxycodone dependence in rats [0.03%]
大鼠氧可酮依赖的应变和性别相关的行为变异
Michelle R Doyle,Angelica R Martinez,Ran Qiao et al.
Michelle R Doyle et al.
Over the past two decades, the escalating prescription of opioid medications for pain management has culminated in a widespread opioid epidemic, significantly impacting public health, social dynamics, and economic stability. The urgent need...
HDAC3 inhibitor (BRD3308) modulates microglial pyroptosis and neuroinflammation through PPARγ/NLRP3/GSDMD to improve neurological function after intraventricular hemorrhage in mice [0.03%]
HDAC3抑制剂(BRD3308)通过PPARγ/NLRP3/GSDMD调节小胶质细胞pyroptosis和神经炎症以改善颅内出血后的小鼠神经功能
Yuanyou Li,Chang Liu,Guoqing Wang et al.
Yuanyou Li et al.
Neuroinflammation plays a vital role in intraventricular hemorrhage (IVH). Excessive neuroinflammation after IVH can activate the inflammasome in the cell and accelerate the occurrence of pyroptosis in cells, produce more inflammatory media...
Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders [0.03%]
纹状体星形胶质细胞A2A-D2受体相互作用及其在神经精神疾病中的作用
Chiara Cervetto,Guido Maura,Diego Guidolin et al.
Chiara Cervetto et al.
It is now generally accepted that astrocytes are active players in synaptic transmission, so that a neurocentric perspective of the integrative signal communication in the central nervous system is shifting towards a neuro-astrocentric pers...
Comparison of dyskinesia profiles after L-DOPA dose challenges with or without dopamine agonist coadministration [0.03%]
左旋多巴剂量滴定试验中联合多巴胺激动剂与不联合多巴胺激动剂的异动症对比研究
Sotirios Grigoriou,Elena Espa,Per Odin et al.
Sotirios Grigoriou et al.
Many patients with Parkinson's disease (PD) experiencing l-DOPA-induced dyskinesia (LID) receive adjunct treatment with dopamine agonists, whose functional impact on LID is unknown. We set out to compare temporal and topographic profiles of...