Glucocorticoid receptor blockade reverses heroin and alcohol withdrawal-induced hyperalgesia in rats [0.03%]
糖皮质激素受体拮抗剂可逆转阿片和酒精戒断引起的痛觉过敏现象
Neha Skandan,Valeria P Acosta,Janaina C M Vendruscolo et al.
Neha Skandan et al.
Rationale: Alcohol use disorder (AUD) and opioid use disorder (OUD) are associated with dysregulation of the hypothalamic-pituitary-adrenal axis and extrahypothalamic stress systems, including glucocorticoid receptor (GR)...
Sex-specific responses on alcohol intake in rodents following sCT infusion in the middle part of the paraventricular nucleus of the thalamus [0.03%]
不同性别小鼠在中脑室旁核注射sCT后的饮酒行为反应差异研究
Cajsa Aranäs,Antonia Caffrey,Christian E Edvardsson et al.
Cajsa Aranäs et al.
Background: Long-term alcohol consumption contributes to the development of alcohol use disorder (AUD), a complex disorder with multifaceted neurobiological underpinnings. One of these is appetite-regulatory peptides, suc...
Inhibiting AP2M1-mediated GluA2 endocytosis by G2CT peptide ameliorates synaptic and memory deficits in Alzheimer's Disease [0.03%]
通过G2CT肽抑制AP2M1介导的GluA2内吞作用改善阿尔茨海默病的突触和记忆缺陷
Mengtong Xue,Yayan Pang,Qiuyun Tian et al.
Mengtong Xue et al.
Abnormal endocytosis of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) subunit GluA2 is implicated in early synaptic dysfunction in Alzheimer's disease (AD). In this study, we utilized human brain tissue samples fr...
The β-amyloid-induced increased tonic conductance, impaired long-term potentiation and cognitive deficits characteristic of Alzheimer's disease are reversed by an α5 inverse agonist of the GABA type A receptor [0.03%]
β-淀粉样蛋白诱导的阿尔茨海默病特征性的增加的持续性电导、长期增强作用受损和认知功能障碍可被GABA受体α5反向激动剂逆转
Aoife O&#x;Connell,Beatriz Calvo-Flores Guzmán,Ying Zhai et al.
Aoife O&#x;Connell et al.
Alzheimer's disease is a chronic, progressive neurodegenerative disorder characterized by cognitive impairment, which may arise from disruptions in the excitatory/inhibitory balance within the brain. Gamma-aminobutyric acid (GABA), the prin...
Dopamine, γ-aminobutyric acid, and glutamate balance in the nucleus accumbens shell: Differential effects of cannabinoid 1 receptor agonists Δ9-Tetrahydrocannabinol, AM11101, and AM8936 [0.03%]
多巴胺、γ-氨基丁酸和核 Accumbens 壳区中的谷氨酸平衡：大麻素1受体激动剂Δ9-四氢大麻酚、AM11101 和 AM8936 的不同效应
Evan C Smith,Christos Iliopoulos-Tsoutsouvas,Markos-Orestis Georgiadis et al.
Evan C Smith et al.
Despite being the most prevalently abused illicit drug class, the neurochemical effects of cannabinoids (CBs) in key reward-related brain regions are not fully understood. Here, we used in vivo microdialysis combined with liquid chromatogra...
Autism-Related Phenotypes in a Heterozygous Scn2aR854Q Mouse Model and Their Partial Rescue via a Potassium Channel Opener [0.03%]
一种异染色体Scn2aR854Q自闭症小鼠模型及相关表型的钾通道开放剂的改善作用
Hossam Ismail,Shaymaa Madbouli Abdalla,Zachary Thomas Carman et al.
Hossam Ismail et al.
The voltage-gated sodium channel NaV1.2, encoded by the SCN2A gene, is frequently implicated in neurodevelopmental and neurological disorders, including developmental and epileptic encephalopathy (DEE) and autism spectrum disorder (ASD). Ge...
Assessment of high-efficacy agonism in synthetic cannabinoid receptor agonists containing l-tert-leucinate [0.03%]
含L-叔亮氨酸类似物合成大麻素受体激动剂高效激动活性评估研究
Christopher Lucaj,Soo Jung Oh,Charlotte Pitha et al.
Christopher Lucaj et al.
Synthetic cannabinoid receptor agonists (SCRAs) represent a class of new psychoactive substances that pose great health risks attributed to their wide-ranging and severe adverse effects. Recent evidence has shown that SCRAs with key moietie...
Chronic ethanol drinking alters medial prefrontal cortex and nucleus accumbens astrocyte translatome and extracellular matrix glycosaminoglycans [0.03%]
慢性乙醇饮用改变中前额皮质和伏隔核星形胶质细胞翻译组和细胞外基质糖胺聚糖
Joel G Hashimoto,Angela R Ozburn,Cheryl Reed et al.
Joel G Hashimoto et al.
Alcohol Use Disorder is a leading preventable cause of morbidity and mortality, yet knowledge of mechanisms driving ethanol-related neuroplasticity remains incomplete. While research has traditionally focused on neuronal signaling, emerging...
Mediodorsal thalamus of alcohol-dependent mice shows genetic and physiological adaptations and alcohol-biased calcium signaling [0.03%]
酒精依赖小鼠的中介背侧丘脑表现出遗传和生理适应性以及偏爱酒精的钙信号传导
Jayden C Martin,Kaitlin C Reeves,Kathryn A Carter et al.
Jayden C Martin et al.
Alcohol Use Disorder (AUD) is a significant health concern characterized by cognitive dysfunction and an inability to control alcohol intake, leading to severe social and health consequences. It is crucial to uncover neuroadaptations and ce...
Diminazene attenuates astrocytic oxidative stress and neuronal ferroptosis via miR-10b-3p/NOX4 axis in Alzheimer's Disease Model [0.03%]
二氮嗪通过miR-10b-3p/NOX4轴减轻阿尔茨海默病模型中的星形胶质细胞氧化应激和神经元铁死亡
Zhaohan Xu,Xiaoyuan Li,Shiyao Wang et al.
Zhaohan Xu et al.
Purpose: Diminazene (DIZE), an agonist of the Ang-(1-7) system, has been proven to suppress astrocytic neuroinflammatory responses in Alzheimer's disease (AD). NADPH oxidase 4 (NOX4) is abundantly expressed in astrocytes ...