Determining the neuronal ensembles underlying sex-specific social impairments following adolescent intermittent ethanol exposure [0.03%]
青春期间歇性饮酒暴露后确定性别特异性社交障碍的神经元群落
Trevor T Towner,Matthew A Goyden,Harper J Coleman et al.
Trevor T Towner et al.
Binge drinking during adolescence can have behavioral and neurobiological consequences. We have previously found that adolescent intermittent ethanol (AIE) exposure produces sex-specific social alterations indexed via decreases of social in...
Ji-Zhou Zhang,Nan-Rui Shi,Jia-Si Wu et al.
Ji-Zhou Zhang et al.
Uridine 5'-diphosphoglucose (UDP-G) as a preferential agonist, but also other UDP-sugars, such as UDP galactose, function as extracellular signaling molecules under conditions of cell injury and apoptosis. Consequently, UDP-G is regarded to...
Postictal hypoxia involves reactive oxygen species and is ameliorated by chronic mitochondrial uncoupling [0.03%]
皮质缺氧涉及活性氧并可通过线粒体去耦来改善
Bianca R Villa,Antis G George,Timothy E Shutt et al.
Bianca R Villa et al.
Prolonged severe hypoxia follows brief seizures and represents a mechanism underlying several negative postictal manifestations without interventions. Approximately 50% of the postictal hypoxia phenomenon can be accounted for by arteriole v...
CGP7930 - An allosteric modulator of GABABRs, GABAARs and inwardly-rectifying potassium channels [0.03%]
CGP7930-GABABR、GABAAR和内向整流型钾通道的变构调节剂
Saad B Hannan,Reka Penzinger,Ginte Mickute et al.
Saad B Hannan et al.
Type-A and -B GABA receptors (GABAARs/GABABRs) control brain function and behaviour by fine tuning neurotransmission. Over-time these receptors have become important therapeutic targets for treating neurodevelopmental and neuropsychiatric d...
Dopaminergic neuroprotective effects of inosine in MPTP-induced parkinsonian mice via brain-derived neurotrophic factor upregulation [0.03%]
尿苷通过上调脑源性神经营养因子发挥多巴胺能神经保护作用机制研究
Shristi Khanal,Eugene Bok,Jaekwang Kim et al.
Shristi Khanal et al.
Parkinson's disease (PD) is the second most common neurodegenerative disease. However, no curative or modifying therapy is known. Inosine is a purine nucleoside that increases brain-derived neurotrophic factor (BDNF) expression in the brain...
Maintenance of optogenetic channel rhodopsin (ChR2) function in aging mice: Implications for pharmacological studies of inhibitory synaptic transmission, quantal content, and calcium homeostasis [0.03%]
光遗传学通道视紫红质（ChR2）在老年小鼠中的功能维护：对抑制性突触传递、量子含量和钙稳态的药理学研究的意义
Dustin W DuBois,David A Murchison,Amanda H Mahnke et al.
Dustin W DuBois et al.
Disruption of synaptic function is believed to represent a common pathway contributing to cognitive decline during aging. Optogenetics is a prodigious tool for studying relationships between function and synaptic circuitry but models utiliz...
Insulin potentiates inhibitory synaptic currents between fast-spiking and pyramidal neurons in the rat insular cortex [0.03%]
胰岛素增强大鼠纹状岛带中快发放神经元和锥体神经元之间的抑制性突触电流作用
Yuka Nakaya,Satoshi Kosukegawa,Satomi Kobayashi et al.
Yuka Nakaya et al.
Insulin plays roles in brain functions such as neural development and plasticity and is reported to be involved in dementia and depression. However, little information is available on the insulin-mediated modulation of electrophysiological ...
Understanding the initiation, delivery and processing of bone cancer pain from the peripheral to the central nervous system [0.03%]
从外周到中枢神经系统启动、传递和处理骨癌痛的机制理解
Lei Yang,Beibei Liu,Shang Zheng et al.
Lei Yang et al.
Bone cancer pain is a complex condition characterized by persistent, sudden, spontaneous pain accompanied by hyperalgesia that typically arises from bone metastases or primary bone tumors, causing severe discomfort and significantly diminis...
Blunted type-5 metabotropic glutamate receptor-mediated polyphosphoinositide hydrolysis in two mouse models of monogenic autism [0.03%]
两种单基因自闭症小鼠模型中迟钝的五型元离子谷氨酸受体介导的多磷酸肌醇水解反应
Luisa Di Menna,Rosamaria Orlando,Giovanna D&#x;Errico et al.
Luisa Di Menna et al.
The involvement of the mGlu5 receptors in the pathophysiology of several forms of monogenic autism has been supported by numerous studies following the seminal observation that mGlu5 receptor-dependent long-term depression was enhanced in t...
The α1 and γ2 subunit-containing GABAA receptor-mediated inhibitory transmission in the anteroventral bed nucleus of stria terminalis is involved in the regulation of anxiety in rats with substantia nigra lesions [0.03%]
中脑黑质损伤大鼠伏隔核α1和γ2亚型GABAA受体介导的抑制性突触传递参与焦虑反应的调节
Ruotong Li,Yong Wang,Yaxin Yang et al.
Ruotong Li et al.
The anteroventral bed nucleus of the stria terminalis (avBNST) is widely acknowledged as a key brain structure that regulates negative emotional states, such as anxiety. At present, it is still unclear whether GABAA receptor-mediated inhibi...