Varenicline enhances recognition memory via α7 nicotinic acetylcholine receptors in the medial prefrontal cortex in male mice [0.03%]
伐尼克兰通过小鼠前额叶皮质α7烟碱型乙酰胆碱受体增强识别记忆
Hirohito Esaki,Satoshi Deyama,Shoma Izumi et al.
Hirohito Esaki et al.
Previous studies postulated that chronic administration of varenicline, a partial and full agonist at α4β2 and α7 nicotinic acetylcholine receptors (nAChRs), respectively, enhances recognition memory. However, whether its acute administr...
Acute alcohol and chronic drinking bidirectionally regulate the excitability of prefrontal cortex vasoactive intestinal peptide interneurons [0.03%]
急性酒精和慢性饮酒双向调节前额皮层血管活性肠肽中间神经元的兴奋性
Shannon M Thompson,Carly B Fabian,Anthony S Ferranti et al.
Shannon M Thompson et al.
The prefrontal cortex (PFC) regulates drinking behaviors and affective changes following chronic alcohol use. PFC activity is dynamically modulated by local inhibitory interneurons (INs), which can be divided into non-overlapping groups wit...
Sestrin 3 promotes oxidative stress primarily in neurons following epileptic seizures in rats [0.03%]
塞斯特林3促进癫痫发作后的氧化应激主要发生在大鼠的神经元中
Rhoda Olowe Taiwo,Sereen Sandouka,Aseel Saadi et al.
Rhoda Olowe Taiwo et al.
Epilepsy affects approximately 1% of the global population, with 30% of patients experiencing uncontrolled seizures despite treatment. Reactive oxygen species (ROS) and oxidative stress have been implicated in the pathogenesis of epilepsy. ...
Graham L Collingridge,Richard H Evans,David E Jane et al.
Graham L Collingridge et al.
Impairments in hippocampal oscillations accompany the loss of LTP induced by GIRK activity blockade [0.03%]
GIRK通道活性抑制引起的LTP缺失伴海马振荡异常
Ana Contreras,Souhail Djebari,Sara Temprano-Carazo et al.
Ana Contreras et al.
Learning and memory occurrence requires of hippocampal long-term synaptic plasticity and precise neural activity orchestrated by brain network oscillations, both processes reciprocally influencing each other. As G-protein-gated inwardly rec...
MPFC PV+ interneurons are involved in the antidepressant effects of running exercise but not fluoxetine therapy [0.03%]
MPFC PV+神经元参与跑步的抗抑郁作用但不参与氟西汀的抗抑郁作用
Lu Qin,Xin Liang,Yingqiang Qi et al.
Lu Qin et al.
Depression is a complex psychiatric disorder. Previous studies have shown that running exercise reverses depression-like behavior faster and more effectively than fluoxetine therapy. GABAergic interneurons, including the PV+ interneuron sub...
ADX106772, an mGlu2 receptor positive allosteric modulator, selectively attenuates oxycodone taking and seeking [0.03%]
一种选择性作用于mGlu2受体的激动剂能有效减少羟考酮的摄入和觅药行为：新型成瘾治疗药物研究取得进展
Jessica M Illenberger,Francisco J Flores-Ramirez,Alessandra Matzeu et al.
Jessica M Illenberger et al.
Opioid abuse and overdose have risen to epidemic proportions in the United States. Oxycodone is the most abused prescription opioid. Treatments for opioid use disorder (OUD) seek to reduce vulnerability to relapse by reducing sources of rei...
Antagonism of P2X7 receptors enhances lorazepam action in delaying seizure onset in an in vitro model of status epilepticus [0.03%]
P2X7受体拮抗能增强劳拉西泮在体外癫痫持续状态模型中延缓发作的作用
Monica Garcia-Durillo,Bruno G Frenguelli
Monica Garcia-Durillo
Approximately 30% of patients with status epilepticus (SE) become refractory to two or more antiseizure medications (ASMs). There is thus a real need to identify novel targets against which to develop new ASMs for treating this clinical eme...
Tumor necrosis factor-α-induced protein 8-like 2 alleviates morphine antinociceptive tolerance through reduction of ROS-mediated apoptosis and MAPK/NF-κB signaling pathways [0.03%]
肿瘤坏死因子α诱导蛋白8样蛋白2通过减少ROS介导的凋亡和MAPK/NF-κB信号通路来缓解阿片类药物耐受性
Zhong Yang,Feifei Zhang,Mannan Abdul et al.
Zhong Yang et al.
Chronic morphine tolerance is a repulsive barrier to the clinical treatment of pain. Whereas the underlying molecular mechanisms of morphine tolerance remain unknown. Here, we proposed that tumor necrosis factor-α-induced protein 8-like 2 ...
The t-N-methyl-d-aspartate receptor: Making the case for d-Serine to be considered its inverse co-agonist [0.03%]
D-丝氨酸作为N-甲基-D天冬氨酸受体的逆向激动剂共激动剂的证据
Stephen Beesley,Sanjay S Kumar
Stephen Beesley
The N-methyl-d-aspartate receptor (NMDAR) is an enigmatic macromolecule that has garnered a good deal of attention on account of its involvement in the cellular processes that underlie learning and memory, following its discovery in the mid...