Modulatory role of α-MSH in hippocampal-dependent memory impairment, synaptic plasticity changes, oxidative stress, and astrocyte reactivity induced by short-term high-fat diet intake [0.03%]
α-MSH在短期高脂饮食诱导的海马依赖性记忆损伤、突触可塑性改变、氧化应激和星形胶质细胞反应性中的调节作用
Guadalupe Herrera,M Jazmín Silvero C,M Cecilia Becerra et al.
Guadalupe Herrera et al.
High-fat diet (HFD) consumption is associated with cognitive deficits and neurodegenerative diseases. Since the hippocampus is extremely sensitive to pathophysiological changes, neuroinflammation and the concomitant oxidative stress induced...
HET0016 inhibits neuronal pyroptosis in the immature brain post-TBI via the p38 MAPK signaling pathway [0.03%]
HET0016通过p38 MAPK信号通路抑制TBI后未成熟脑神经元的焦亡
Xiaoli Chen,Yalei Ning,Bo Wang et al.
Xiaoli Chen et al.
Traumatic brain injury (TBI) is a serious health threat worldwide, especially for the younger demographic. Our previous study demonstrated that HET0016 (a specific inhibitor of 20-hydroxyeicosatetraenoic acid synthesis) can decrease the les...
Daily treatment with the dual orexin receptor antagonist DORA-12 during oxycodone abstinence decreases oxycodone conditioned reinstatement [0.03%]
在丁丙诺啡戒断期间每天使用双重氧化素受体拮抗剂DORA-12可减少丁丙诺啡条件作用的复燃
Jessica M Illenberger,Francisco J Flores-Ramirez,Glenn Pascasio et al.
Jessica M Illenberger et al.
Chronic opioid use disturbs circadian rhythm and sleep, encouraging opioid use and relapse. The orexin (OX) system is recruited by opioids and regulates physiological processes including sleep. Dual OX receptor antagonists (DORAs), develope...
PYY3-36 infused systemically or directly into the VTA attenuates fentanyl seeking in male rats [0.03%]
静脉注射或直接向伏隔核注射PYY3-36可减轻雄性大鼠对芬太尼的寻求行为
A Caffrey,E Lavecchia,R Merkel et al.
A Caffrey et al.
More effective treatments for fentanyl use disorder are urgently needed. An emerging literature indicates that glucagon-like peptide-1 receptor (GLP-1R) agonists attenuate voluntary opioid taking and seeking in rodents. However, GLP-1R agon...
Progressive development of synchronous activity in the hippocampal neuronal network is modulated by GluK1 kainate receptors [0.03%]
GluK1谷氨酸受体调控海马神经网络同步活动的发展成熟过程
Tsvetomira Atanasova,Tiina Savonlehto,Tiina-Kaisa Kukko-Lukjanov et al.
Tsvetomira Atanasova et al.
Kainate receptors are potent modulators of circuit excitability and have been repeatedly implicated in pathophysiological synchronization of limbic networks. While the role of aberrant GluK2 subunit containing KARs in generation of epilepti...
(R,S)-trihexyphenidyl, acting via a muscarinic receptor-independent mechanism, inhibits hippocampal glutamatergic and GABAergic synaptic transmissions: Potential relevance for treatment of organophosphorus intoxication [0.03%]
(R，S)-苯海索通过胆碱能受体非依赖性机制抑制海马区谷氨酸能和GABA能突触传递：治疗有机磷中毒的潜在意义
Yasco Aracava,Edson X Albuquerque,Edna F R Pereira
Yasco Aracava
Preclinical studies have reported that, compared to the muscarinic receptor (mAChR) antagonist atropine, (R,S)-trihexyphenidyl (THP) more effectively counters the cholinergic crisis, seizures, and neuropathology triggered by organophosphoru...
The Notch1/Hes1 signaling pathway affects autophagy by adjusting DNA methyltransferases expression in a valproic acid-induced autism spectrum disorder model [0.03%]
notch1/hes1信号通路通过调节dna甲基转移酶的表达影响自闭症模型小鼠的自噬作用
Yanfang Li,Liping Ma,Yanan Deng et al.
Yanfang Li et al.
As a pervasive neurodevelopmental disease, autism spectrum disorder (ASD) is caused by both hereditary and environmental elements. Research has demonstrated the functions of the Notch pathway and DNA methylation in the etiology of ASD. DNA ...
Buprenorphine and methadone differentially alter early brain development in human cortical organoids [0.03%]
丁丙诺啡和美沙酮对人皮层类器官早期脑发育的影响不同
Hang Yao,Daisy Hu,Juan Wang et al.
Hang Yao et al.
Buprenorphine (BUP) and methadone (MTD) are used for medication-assisted treatment (MAT) in opioid use disorder. Although both medications show improved maternal and neonatal outcomes compared with illicit opioid use during pregnancy, BUP h...
CB1 receptor expression and signaling are required for dexamethasone-induced aversive memory consolidation [0.03%]
氯羟苯吡嗪受体表达和信号传导是 dex 所诱导的厌恶记忆巩固所必需的
Gina Granja-Galeano,Ana Paula Dominguez-Rubio,C Daniel Zappia et al.
Gina Granja-Galeano et al.
The molecular processes that underlie long-term memory formation involve signaling pathway activation by neurotransmitter release, which induces the expression of immediate early genes, such as Zif268, having a key role in memory formation....
Tetrandrine attenuates SNI-induced mechanical allodynia by inhibiting spinal CKLF1 [0.03%]
Tetrandrine通过抑制脊髓CKLF1对SNI诱导的机械性疼痛产生缓解作用
Zhi-Ling Zhang,Zhi-Tong Wang,Jing Shi et al.
Zhi-Ling Zhang et al.
Neuropathic pain (NP) is a prevalent clinical problem for which satisfactory treatment options are unavailable. Tetrandrine (TET), a bisbenzylisoquinoline alkaloid extracted from Stephania tetrandra S. Moore, possesses anti-inflammatory and...