Perirhinal to prefrontal circuit in methamphetamine induced recognition memory deficits [0.03%]
甲氨蝶呤引起的识别记忆缺损的腹侧纹状体到前额叶环路
Jordan L Hopkins,Sarah T Goldsmith,Samuel K Wood et al.
Jordan L Hopkins et al.
Return to methamphetamine (meth) use is part of an overarching addictive disorder hallmarked by cognitive sequela and cortical dysfunction in individuals who use meth chronically. In rats, long access meth self-administration produces objec...
Click-train evoked steady state harmonic response as a novel pharmacodynamic biomarker of cortical oscillatory synchrony [0.03%]
基于皮层振荡同步性的稳态谐波响应作为新型药理动力学生物标志物的研究
Deepshila Gautam,Muhammad Ummear Raza,M Miyakoshi et al.
Deepshila Gautam et al.
Sensory networks naturally entrain to rhythmic stimuli like a click train delivered at a particular frequency. Such synchronization is integral to information processing, can be measured by electroencephalography (EEG) and is an accessible ...
Hydralazine inhibits neuroinflammation and oxidative stress in APP/PS1 mice via TLR4/NF-κB and Nrf2 pathways [0.03%]
hydralazine通过TLR4/NF-κB和Nrf2途径抑制APP / PS1小鼠的神经炎症和氧化应激
Yu Wang,Jiayang Zou,Yue Wang et al.
Yu Wang et al.
Alzheimer's disease (AD) is a common chronic progressive neurodegenerative disorder, and curative treatment has not been developed. The objective of this study was to investigate the potential effects of hydralazine (Hyd, a hypertension tre...
Cue-induced reinstatement of seeking behavior in male rats is independent from the rewarding value of the primary reinforcer: Effect of mGluR5 blockade [0.03%]
条件刺激诱导的雄性大鼠觅取行为的恢复与主要强化物的奖赏价值无关： metabotropic glutamate receptor 5（mGluR5）拮抗剂的影响
Marsida Kallupi,Roberto Ciccocioppo
Marsida Kallupi
Environmental conditioning factors have a profound impact on alcohol-seeking behavior and the maintenance of alcohol use in individuals with alcohol dependence. Cues associated with alcohol, depending on the perceived value of the primary r...
A novel inhibitory corticostriatal circuit that expresses mu opioid receptor-mediated synaptic plasticity [0.03%]
一种表达μ型阿片受体介导的突触可塑性的抑制性皮层纹状体环路
Braulio Munoz,Brady K Atwood
Braulio Munoz
Corticostriatal circuits are generally characterized by the release of glutamate neurotransmitter from cortical terminals within the striatum. It is well known that cortical excitatory input to the dorsal striatum regulates addictive drug-r...
Altered resting-state cerebellar-cerebral functional connectivity in patients with panic disorder before and after treatment [0.03%]
治疗前和治疗后惊恐障碍患者休息态小脑-大脑功能连接的改变
Haohao Yan,Yiding Han,Xiaoxiao Shan et al.
Haohao Yan et al.
The study aimed to investigate the functional connectivity (FC) between the cerebellum and intrinsic cerebral networks in patients with panic disorder (PD), and to observe changes in the cerebellar-cerebral FC following pharmacotherapy. Fif...
Phosphorylated Ser187-SNAP25-modulated hyperfunction of glutamatergic system in the vmPFC mediates depressive-like behaviors in male mice [0.03%]
雄性小鼠抑郁样行为的表型中，磷酸化Ser187-SNAP25介导vmPFC谷氨酸能系统过度活化所致机制研究
Xinjuan Wang,Xueyu Hou,Yu Huo et al.
Xinjuan Wang et al.
Dysfunctional glutamatergic neurotransmission contributes importantly to the pathophysiology of depression. However, the underlying neural mechanisms of glutamatergic dysfunction remain poorly understood. Here, we employed chronic unpredict...
The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases [0.03%]
微生物群-肠-脑轴中吲哚类衍生物的作用及潜在治疗靶点：重点关注人类神经和神经精神疾病
Yi Zhou,Yue Chen,Hui He et al.
Yi Zhou et al.
At present, a large number of relevant studies have suggested that the changes in gut microbiota are related to the course of nervous system diseases, and the microbiota-gut-brain axis is necessary for the proper functioning of the nervous ...
Withdrawal from repeated nicotine vapor exposure increases somatic signs of physical dependence, anxiety-like behavior, and brain reward thresholds in adult male rats [0.03%]
反复接触尼古丁气溶胶的撤药加重雄性大鼠身体依赖体征、焦虑样行为和大脑奖赏阈值
Michelle Martínez,Veronika E Espinoza,Valeria Garcia et al.
Michelle Martínez et al.
Nicotine vapor consumption via electronic nicotine delivery systems has increased over the last decade. While prior work has shed light on the health effects of nicotine vapor inhalation, its unique effects on the brain and behavior have no...
Acute administration of the NMDA receptor antagonists ketamine and MK-801 reveals dysregulation of glutamatergic signalling and sensorimotor gating in the Sapap3 knockout mouse model of compulsive-like behaviour [0.03%]
NMDA受体拮抗剂氯胺酮和MK-801急性给药揭示了Sapap3基因敲除小鼠模型中强迫样行为的谷氨酸能信号转导和感觉运动门控失调
James J Gattuso,Carey Wilson,Anthony J Hannan et al.
James J Gattuso et al.
Obsessive-compulsive disorder (OCD) is characterised by excessive intrusive thoughts that may cause an individual to engage in compulsive behaviours. Frontline pharmacological treatments (i.e., selective serotonin reuptake inhibitors (SSRIs...