Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway [0.03%]
司美格鲁肽通过GLP-1受体/SIRT1/GLUT4信号通路改善三转基因小鼠模型的认知和糖代谢障碍
Zhao-Jun Wang,Xin-Ru Li,Shi-Fan Chai et al.
Zhao-Jun Wang et al.
Disorders of brain glucose metabolism is known to affect brain activity in neurodegenerative diseases including Alzheimer's disease (AD). Furthermore, recent evidence has shown an association between AD and type 2 diabetes. Numerous reports...
Restoring prefrontal cortical excitation-inhibition balance with cannabidiol ameliorates neurobehavioral abnormalities in a mouse model of neurodevelopmental disorders [0.03%]
大麻二酚通过恢复前额叶皮层兴奋抑制平衡来改善神经发育障碍小鼠模型的神经行为异常现象
Lu Zhang,Chunqiao Lin,Jiushuang Zhu et al.
Lu Zhang et al.
Maternal immune activation (MIA) resulting from viral infections during pregnancy is linked to increased rates of neurodevelopmental disorders in offspring. However, the mechanisms underlying MIA-induced neurobehavioral abnormalities remain...
Mephedrone induces partial release at human dopamine transporters but full release at human serotonin transporters [0.03%]
甲卡西酮对人的多巴胺和五羟色胺转运蛋白的部分释放诱导作用
Felix P Mayer,Marco Niello,Simon Bulling et al.
Felix P Mayer et al.
Mephedrone (4-methylmethcathinone) is a cathinone derivative that is recreationally consumed for its energizing and empathogenic effects. The stimulating properties are believed to arise from the ability of mephedrone to interact with the h...
The different cell-specific mechanisms of voluntary exercise and forced exercise in the nucleus accumbens [0.03%]
自愿运动和强迫运动在伏隔核中的不同细胞特异性机制
Yixia Gan,Yigang Dong,Shanghua Dai et al.
Yixia Gan et al.
Physical inactivity is a global epidemic. People who take the initiative to exercise will feel pleasure during the exercise process and stick with it for a long time, while people who passively ask for exercise will feel pain and cannot sti...
An integrated approach to evaluate the functional effects of disease-associated NMDA receptor variants [0.03%]
整合方法评估疾病相关NMDA受体变异体的功能效应
Gabrielle Moody,Angela Musco,Joseph Bennett et al.
Gabrielle Moody et al.
The NMDA receptor (NMDAR) is a ubiquitously expressed glutamate-gated ion channel that plays key roles in brain development and function. Not surprisingly, a variety of disease-associated variants have been identified in genes encoding NMDA...
Hallucinogenic activity, neurotransmitters release, anxiolytic and neurotoxic effects in Rat's brain following repeated administration of novel psychoactive compound 25B-NBOMe [0.03%]
新型精神活性物质25B-NBOMe重复给药后的大鼠脑幻觉、神经递质释放及抗焦虑和神经毒性作用研究
Adam Wojtas,Monika Herian,Marzena Maćkowiak et al.
Adam Wojtas et al.
2-(4-Bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)etanoamine (25B-NBOMe) is a highly selective 5-HT2A receptor agonist, exhibiting a potent hallucinogenic activity. In the present study, we investigated the effect of a 7-day treatment with...
Selective inhibition of cannabinoid CB1 receptor-evoked signalling by the interacting protein GAP43 [0.03%]
GAP43选择性抑制大麻素CB1受体诱发的信号转导
Irene B Maroto,Estefanía Moreno,Carlos Costas-Insua et al.
Irene B Maroto et al.
Cannabinoids exert pleiotropic effects on the brain by engaging the cannabinoid CB1 receptor (CB1R), a presynaptic metabotropic receptor that regulates key neuronal functions in a highly context-dependent manner. We have previously shown th...
Volatile anesthetics inhibit presynaptic cGMP signaling to depress presynaptic excitability in rat hippocampal neurons [0.03%]
吸入麻醉药通过抑制大鼠海马神经元突触前环磷酸鸟苷(cGMP)信号转导降低其兴奋性
Iris Speigel,Kishan Patel,Vanessa Osman et al.
Iris Speigel et al.
Volatile anesthetics alter presynaptic function through effects on Ca2+ influx and neurotransmitter release. These actions are proposed to play important roles in their pleiotropic neurophysiological effects including immobility, unconsciou...
Dexmedetomidine relieves inflammatory pain by enhancing GABAergic synaptic activity in pyramidal neurons of the anterior cingulate cortex [0.03%]
右美托咪定通过增强前扣带回皮质锥体神经元的GABA能突触活性缓解炎症痛
Ling Liu,Zhihao Luo,Yuanying Mai et al.
Ling Liu et al.
Pyramidal neuron (Pyn) hyperactivity in the anterior cingulate cortex (ACC) is involved in the modulation of pain. Previous studies indicate that the activation of α2 adrenoceptors (α2-ARs) by dexmedetomidine (DEX) is a safe and effective...
Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus [0.03%]
鼻内给药脂多糖诱发的小胶质细胞活化通过ERK1/2-BDNF信号产生类似抗抑郁作用
Mingxie Ni,Meng Zheng,Bingran Chen et al.
Mingxie Ni et al.
We recently reported that reversing the chronic stress-induced decline of microglia in the dentate gyrus (DG) of the hippocampus by intraperitoneal injection of a low dose of lipopolysaccharide (LPS) ameliorated depression-like behavior in ...