Social defeat stress enhances the rewarding effects of cocaine through α1A adrenoceptors in the medial prefrontal cortex of mice [0.03%]
社交挫败应激通过小鼠前额叶皮层α1A肾上腺素受体增强可卡因的奖赏效应
Atsushi Saito,Haruka Murata,Kazuhei Niitani et al.
Atsushi Saito et al.
Various stressors potentiate the rewarding effects of cocaine and contribute to cocaine cravings. However, it remains unclear whether psychosocial stress enhances the rewarding effects of cocaine. Accordingly, this study employed a cocaine-...
Serotonergic and noradrenergic contributions to motor cortical and spinal motoneuronal excitability in humans [0.03%]
人五羟色胺能和去甲肾上腺素能对运动皮质和脊髓运动神经元兴奋性的影响
Jacob R Thorstensen,Tyler T Henderson,Justin J Kavanagh
Jacob R Thorstensen
Animal models indicate that motor behaviour is shaped by monoamine neuromodulators released diffusely throughout the brain and spinal cord. As an alternative to conducting a single study to explore the effects of neuromodulators on the huma...
Tafluprost promotes axon regeneration after optic nerve crush via Zn2+-mTOR pathway [0.03%]
塔夫洛普罗斯特通过Zn2+-mTOR途径促进视神经挫伤后的轴突再生
Siting Wu,Canying Liu,Jiahui Tang et al.
Siting Wu et al.
Purpose: To investigate whether Tafluprost could promote optic nerve regeneration in mice after optic nerve crush (ONC) and determine the underlying molecular mechanism. ...
Memantine: Updating a rare success story in pro-cognitive therapeutics [0.03%]
美金刚：认知促进治疗领域的一种少见的成功疗法的更新故事
Parisa Karimi Tari,Chris G Parsons,Graham L Collingridge et al.
Parisa Karimi Tari et al.
The great potential for NMDA receptor modulators as druggable targets in neurodegenerative disorders has been met with limited success. Considered one of the rare exceptions, memantine has consistently demonstrated restorative and prophylac...
Modulation of GABA release by 5-HT1B receptors: An interplay with AMPA-receptors and voltage-gated Ca2+ channels [0.03%]
五羟色胺1B受体调节GABA释放：与AMPA受体及电压门控钙通道相互作用
Dhamyaa Abed Najm Al-Halboosi,Olena Savchenko,Lora K Heisler et al.
Dhamyaa Abed Najm Al-Halboosi et al.
Obesity has become a worldwide health challenge and commonly results from the intake of more calories than the body requires. The brain represents the master controller of food intake and as such has been the target of obesity medications. ...
CCK-8 enhances acid-sensing ion channel currents in rat primary sensory neurons [0.03%]
CCK-8增强大鼠初级感觉神经元的酸感受离子通道电流
Qing-Rui Qin,Zhong-Qing Xu,Ting-Ting Liu et al.
Qing-Rui Qin et al.
Cholecystokinin (CCK) is a peptide that has been implicated in pain modulation. Acid sensitive ion channels (ASICs) also play an important role in pain associated with tissue acidification. However, it is still unclear whether there is an i...
RTI-263, a biased neuropeptide S receptor agonist that retains an anxiolytic effect, attenuates cocaine-seeking behavior in rats [0.03%]
偏向性神经肽S受体激动剂RTI-263可产生抗焦虑效应并减少大鼠对可卡因的寻求行为
Yuanli Huang,Alaina Wojciechowski,Kyle Feldman et al.
Yuanli Huang et al.
Neuropeptide S (NPS) is a neuromodulatory peptide that acts via a G protein-coupled receptor. Centrally administered NPS suppresses anxiety-like behaviors in rodents while producing a paradoxical increase in arousal. In addition, NPS increa...
Bipolar mania and epilepsy pathophysiology and treatment may converge in purine metabolism: A new perspective on available evidence [0.03%]
嘌呤代谢可能使双相躁狂和癫痫的病理生理学及治疗方法交汇：对现有证据的新见解
Scott D Daniels,Detlev Boison
Scott D Daniels
Decreased ATPergic signaling is an increasingly recognized pathophysiology in bipolar mania disease models. In parallel, adenosine deficit is increasingly recognized in epilepsy pathophysiology. Under-recognized ATP and/or adenosine-increas...
Acute anxiogenic effects of escitalopram are associated with mild alterations in D-amphetamine-induced behavior and social approach evoked by playback of 50-kHz ultrasonic vocalizations in rats [0.03%]
艾司西酞普兰急性焦虑作用与对右旋苯丙胺诱导的行为和由播放50kHz超声波信号引发的社会接近行为的轻微改变有关
Maria Willadsen,Rainer K W Schwarting,Markus Wöhr
Maria Willadsen
Rats communicate through auditory signals in the ultrasonic range, so-called ultrasonic vocalizations (USV). Short, high-frequency 50-kHz USV are associated with positive affective states and are emitted in appetitive situations, often rewa...
Corrigendum to "New paradigms in purinergic receptor ligand discovery" [Neuropharmacology 230 (2023) 109503] [0.03%]
关于“嘌呤受体配体发现的新范式”的勘误(神经药理学第230卷(2023年)109503号)
Kenneth A Jacobson,Balaram Pradhan,Zhiwei Wen et al.
Kenneth A Jacobson et al.
Published Erratum
Neuropharmacology. 2023 Dec 15:241:109731. DOI:10.1016/j.neuropharm.2023.109731 2023