Running exercise attenuates excitatory synaptic loss in the medial prefrontal cortex of CUS rats: Potential modulation of microglial and astrocytic synaptic contacts [0.03%]
跑步通过调节小胶质细胞和星形胶质细胞对突触的接触减轻慢性应激大鼠前额叶皮层突触丢失
Xing-Yu Wu,Shan Liu,Qian Xiao et al.
Xing-Yu Wu et al.
Reduction of excitatory synapses in the medial prefrontal cortex (mPFC) is closely associated with depression and can be mitigated by running exercise. However, precise quantitative studies focusing on subregion-specific excitatory synaptic...
A novel rat model harboring two BDNF gene mutations exhibiting autism-like behaviors and cognitive impairments [0.03%]
一个新的携带两个脑源性神经营养因子基因突变的患自闭症样的行为和认知障碍的大鼠模型
Zeping Xue,Junying Lan,Yueyang Zhao et al.
Zeping Xue et al.
Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder that occurs most frequently in early childhood, affecting approximately 1% of the global population. Currently, the elusive nature of the pathological mechanisms underl...
Cannabidiol reduces the latency for the behavioral effect of escitalopram in chronically stressed male mice: involvement of NAPE-PLD expressed in parvalbumin-positive interneurons and the prefrontal cortex [0.03%]
大麻二酚能减少慢性应激小鼠的行为效应的伏隔核舌状部通路的作用机制研究
FrancieleF Scarante,Vinícius D Lopes,Eduardo J Fusse et al.
FrancieleF Scarante et al.
Antidepressant drugs are the first-line treatment for chronic stress-related psychiatric disorders such as major depressive disorder, anxiety disorders, and post-traumatic stress disorder. However, their delayed-onset of therapeutic action,...
Anxiety in male psoriasis mouse model is mediated by the interaction between γδ T cell-derived IL-17A and microglia [0.03%]
雄性银屑病小鼠模型中焦虑由γδ T细胞来源的IL-17A与小胶质细胞互作介导
Juexi Yang,Song Zhang,Cuiying Fu et al.
Juexi Yang et al.
Objective: Both clinical and animal studies indicate a high incidence of anxiety in psoriasis, though the underlying mechanisms remain poorly understood. Our previous review suggested that T cells, related cytokines, and ...
Tetramethylpyrazine mitigates ER-stress-driven ATF4/CHOP apoptosis to protect dopaminergic neurons in cellular and MPTP models of Parkinson's disease [0.03%]
Tetramethylpyrazine通过减轻ER压力驱动的ATF4/CHOP凋亡来保护帕金森氏病细胞和MPTP模型中的多巴胺能神经元
Sha Zhan,Shaowen Wen,Lili Wu et al.
Sha Zhan et al.
Parkinson's disease (PD) is a prevalent neurodegenerative disorder lacking effective disease-modifying therapies, with neuronal death critically linked to endoplasmic reticulum stress (ERS) and the activation of the activating transcription...
Fisetin targets multiple signaling pathways to suppress microglia-mediated neuroinflammation and cognitive decline in Alzheimer's disease [0.03%]
山奈酚通过靶向多种信号通路抑制微胶质细胞介导的阿尔茨海默病神经炎症和认知衰退作用
Yu-Ting Dai,Qian Chen,Yan-Dong Ma et al.
Yu-Ting Dai et al.
Neuroinflammation driven by dysfunctional microglial responses represents a critical early pathogenic process, particularly in the context of Alzheimer's disease (AD). The natural flavonoid fisetin possesses anti-inflammatory characteristic...
Hypocretin receptor 1 blockade early in abstinence reduces future demand for cocaine [0.03%]
abstention早期抑制 hypocretin受体1可降低以后的可卡因需求量
Shanna B Samels,Jessica K Shaw,I Pamela Alonso et al.
Shanna B Samels et al.
Relapse to cocaine use after periods of abstinence remains a significant challenge for treating cocaine use disorder. While the neurobiological mechanisms underlying relapse are still under investigation, adaptations in mesolimbic dopamine ...
Dentate gyrus microglial dynamics contributes to high-fat diet-induced depression-like behaviors in mice [0.03%]
齿状回小胶质细胞动态参与高脂饮食诱导的小鼠抑郁样行为
Tao Zhu,Minxiu Ye,Chao Huang et al.
Tao Zhu et al.
High-fat diet (HFD) consumption is a harmful habit worldwide that can lead to various problems, including an increased risk of depression. However, the mechanisms underlying HFD-induced depression remain unclear. Previous studies have repor...
Functional interaction between orexin/CRF and orexin/dynorphin transmission in the infralimbic cortex modulates the stress-induced reinstatement of alcohol-seeking behavior in male and female Wistar rats [0.03%]
下顶叶皮层的食欲素/CRF和食欲素/多啡信号传递的功能性交互作用可调节Wistar大鼠的压力诱导的觅酒行为的恢复反应
Francisco J Flores-Ramirez,Rémi Martin-Fardon
Francisco J Flores-Ramirez
Stress contributes to the chronic relapsing nature of alcohol use disorder (AUD), given its ability to elicit craving and precipitate relapse, even after long periods of self-imposed abstinence. Although not thoroughly understood, anatomica...
Repeated fentanyl administration impairs spatial memory, synaptic plasticity, and induces neuroinflammation in the dorsal hippocampus of rats [0.03%]
反复注射芬太尼可损害大鼠海马区的空间记忆、突触可塑性并诱导神经炎症
Gabriela Rocha-Botello,Silvia L Cruz,Emilio J Galván
Gabriela Rocha-Botello
Repeated opioid exposure, including therapeutic or illicit fentanyl (Fnt) use, disrupts the hippocampal network activity that supports learning and memory. However, the cellular mechanisms underlying these effects remain elusive. To elucida...