Exploring the role of ventrolateral periaqueductal gray in remifentanil-induced postoperative hyperalgesia [0.03%]
研究外侧导水管周围灰质在雷米芬太尼诱导的术后痛觉过敏中的作用
Huiyue Han,Bingjing Sun,Lianjun Li et al.
Huiyue Han et al.
Remifentanil-induced postoperative hyperalgesia (RIH) delays recovery, prolongs hospitalization, and may contribute to chronic pain. The ventrolateral periaqueductal gray (vlPAG) is a critical area for processing pain and supporting opioid-...
Disruption of psychostimulant-associated memories by single, low dose ketamine in rats [0.03%]
氯胺酮阻断兴奋剂相关记忆的作用研究
Angela E Gonzalez,Jonathan D Ramos,Zada Anderson et al.
Angela E Gonzalez et al.
Cocaine and methamphetamine use disorders pose public health concerns due to the high propensity for relapse driven by persistent drug-associated memories. Output from the medial prefrontal cortex (mPFC) regulates relapse and is controlled ...
Synbiotics inhibits gut microbiome perturbation-induced prolongation of migraine-like pain by restoring short-chain fatty acid signaling [0.03%]
合生元通过恢复短链脂肪酸信号传导抑制肠道微生物组紊乱引起的 migraine样疼痛持续时间延长现象
Yuanyuan Tang,Liping Guan,Zeyang Li et al.
Yuanyuan Tang et al.
Migraine is the most common disabling primary headache disorder. However, currently available therapies for migraine pain are still limited. In the present study, we investigated the effects of gut microbiome perturbation and synbiotics sup...
The MAP6-NTS axis in hippocampal CA1 regulates synaptic plasticity and memory [0.03%]
MAP6-NTS轴通过调控海马CA1区突触可塑性和记忆形成
Yanan Jia,Jintao Lei,Yunrui Jiang et al.
Yanan Jia et al.
Microtubule-associated Protein 6 (MAP6) is critical for maintaining microtubule stability and synaptic plasticity, and its dysfunction is a key driver of cognitive impairment. However, the molecular mechanisms linking MAP6 deletion to cogni...
Glutamatergic cannabinoid receptor 1 confers neuroprotection against ischemic stroke by suppressing excitotoxicity and anoxic depolarization [0.03%]
谷氨酸 cannabinoids 受体通过抑制兴奋性和缺氧去极化对缺血性卒中具有神经保护作用
Yitong Jiang,Mingqing Tao,Congpeng Zhang et al.
Yitong Jiang et al.
Cannabinoid receptor 1 (CB1R) is widely expressed in the brain and implicated in protection against ischemic stroke, yet its cell-type-specific functions remain incompletely understood. To systematically dissect the contributions of excitat...
Ajugol ameliorates mitochondrial dysfunction and cognitive decline in Alzheimer's Disease via BNIP3-dependent mitophagy [0.03%]
通过BNIP3依赖的自噬改善阿尔茨海默病中的线粒体功能障碍和认知衰退
Yuan Qiao,Mengmeng Huang,Cuiting Sun et al.
Yuan Qiao et al.
Defective mitophagy plays key roles in mitochondrial dysfunction, inflammation, and energy deprivation, and this defect can lead to synaptic loss and cognitive decline in Alzheimer's disease (AD). Although pharmacological enhancement of mit...
Neuropharmacology of novel synthetic opioids (NSOs): An ever-expanding challenge for public health and safety [0.03%]
新一代合成阿片类药物的神经药理学：对公共卫生和安全的挑战不断加大
Michael H Baumann,Grant C Glatfelter,Marthe M Vandeputte
Michael H Baumann
Beyond the toad's kiss: Mapping acute 5-MeO-DMT effects on brain connectivity across sex and dose using awake rat neuroimaging [0.03%]
超越青蛙的吻：使用清醒大鼠神经影像技术绘制急性5-甲氧基-N, N-二甲基色胺对大脑连接性的影响地图（按性别和剂量划分）
Noah Cavallaro,Priya Rai,David Akins et al.
Noah Cavallaro et al.
Background: 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent serotonergic psychedelic with rapid therapeutic potential for depression and anxiety disorders. Despite growing clinical interest, the neurobiological m...
Differential inhibition of the diverse behavioural effects of mu-opioid receptor agonists by progressive receptor depletion [0.03%]
渐进性受体耗竭对μ-阿片受体激动剂多方面行为效应的选择性抑制作用不同
Lauren Brown,Cory Langreck,Frances Hough et al.
Lauren Brown et al.
Mu-opioid receptor (MOR) agonists remain the mainstay treatment for severe acute pain but are limited by adverse effects including respiratory depression and constipation. Compounds with improved therapeutic profiles have been reported, and...
Dose- and sex-related effects of the MAGL inhibitor MCH11 on binge-like ethanol consumption in mice [0.03%]
剂量和性别相关的MAGL抑制剂MCH11对小鼠醉酒如乙醇消费的影响
Abraham B Torregrosa,María S García-Gutiérrez,Jorge Manzanares
Abraham B Torregrosa
The effects of MCH11, a novel monoacylglycerol lipase inhibitor, were evaluated on binge-like ethanol consumption using the drinking-in-the-dark paradigm in male and female C57BL/6J mice. Rodents underwent 4 weeks of binge drinking, and MCH...