Annexin A1 and its N-terminal peptide Ac2-26 regulate dopaminergic degeneration and neuroinflammation in a 6-OHDA model of Parkinson's disease [0.03%]
annexin a1及其n端肽ac2-26在6-ohda诱导的帕金森病模型中的作用机制研究
Luiz Philipe de Souza Ferreira,Rafael André da Silva,Nilma R L L Janisset et al.
Luiz Philipe de Souza Ferreira et al.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss, and growing evidence highlights neuroinflammation as a key contributor to disease progression. Annexin A1 (AnxA1), a glucocorticoid-regulate...
Corrigendum to "Exploring the role of ghrelin and des-acyl ghrelin in chemotherapy-induced nausea and vomiting" [Neuropharmacology 251 (2024) 109919] [0.03%]
关于“探讨ghrelin和des-acyl ghrelin在化疗诱导的恶心和呕吐中的作用”的勘误修正[神经药理学第251卷(2024年)109919号论文]
Lingqing Yang,Charmaine J S Kung,Zengbing Lu et al.
Lingqing Yang et al.
Published Erratum
Neuropharmacology. 2026 Mar 23:110897. DOI:10.1016/j.neuropharm.2026.110897 2026
Effects of Npy1r limbic conditional knock-out on adipose tissue metabolism [0.03%]
Npy1r条件性敲除小鼠海马区对脂肪组织代谢的影响研究
Giacomo Einaudi,Alessandra Oberto,Ilaria Bertocchi et al.
Giacomo Einaudi et al.
Neuropeptide Y (NPY) is a key regulator of energy homeostasis, acting through various receptor subtypes in both central and peripheral systems. Increasing interest has been directed toward exploiting NPY as a pharmacological target in obesi...
c/EBPβ-driven Uchl3-mediated deubiquitination of TRPV1 promotes neuropathic pain by inducing mitochondrial fission in male rats [0.03%]
C/EBPβ驱动的Uchl3介导的TRPV1去泛素化通过诱导雄性大鼠神经病理性疼痛中线粒体分裂促进神经病理性疼痛
Ziyun Qiang,Dongxue Sun,Qian Lei et al.
Ziyun Qiang et al.
This study investigates the mechanism of the TRPV1 channel in neuropathic pain (NP), focusing on the c/EBPβ/Uchl3/TRPV1 axis and mitochondrial dynamics. Using male rats chronic constriction injury (CCI) model and an LPS-induced dorsal root...
Aggression after intermittent ethanol intoxication in mice: Sex differences and modulation via medial amygdala relaxin-3/RXFP3 signaling [0.03%]
间断乙醇暴露后小鼠的攻击行为：性别差异及外侧杏仁核 Relaxin-3/RXFP3 信号的作用
Mohamed Aly Zahran,Aroa Mañas-Ojeda,Mónica Navarro Sánchez et al.
Mohamed Aly Zahran et al.
Alcohol consumption is strongly associated with aggression and violence in humans, yet the underlying neurobiological mechanisms within key aggression circuits remain poorly understood. In this preclinical study, we examined the effects of ...
2-Phenyl-3-(phenylselanyl)benzofuran attenuates depressive-like behavior and memory deficits induced by subchronic glucocorticoid exposure in female Swiss mice: role of redox and neurochemical mechanisms [0.03%]
2-苯基-3-(亚酚基)苯并呋喃通过氧化和神经化学机制缓解慢性糖皮质激素暴露诱导的小雌性瑞士小鼠的抑郁样行为和记忆缺损
Dianer Nornberg Strelow,Mariana Parron Paim,Taís da Silva Teixeira Rech et al.
Dianer Nornberg Strelow et al.
Preclinical studies are valuable tools for screening new drugs, and reports suggest that the administration of glucocorticoids, such as dexamethasone (DEX), can induce neurochemical and behavioral changes linked to depression and memory def...
Bacoside-A enhances temozolomide-induced cytotoxicity in U87MG glioblastoma cells via ROS-mediated apoptosis and EGFR/MAPK inhibition [0.03%]
巴可SIDE-A通过ROS介导的凋亡和EGFR/MAPK抑制增强巴可SIDE-A在U87MG胶质母细胞瘤细胞中诱导的细胞毒性
A K Mohammed Unais,Anandan Aparna,K Saju Mariya et al.
A K Mohammed Unais et al.
Temozolomide (TMZ) is the primary chemotherapeutic agent for glioblastoma multiforme (GBM), but its effectiveness is limited by resistance, recurrence, and toxicity. Combining natural compounds with TMZ is a promising approach to overcome t...
Differential effects of cariprazine, LY379268 and donepezil on EEG oscillations and auditory steady-state response in MK-801-treated rats: relevance for schizophrenia drug development [0.03%]
卡利拉嗪、LY379268和石杉碱甲对MK-801所致大鼠脑电振荡及听觉稳态反应的影响：与精神分裂症药物研发的相关性
Florian W Adraoui,Maëlle Violas,Heloise Herbel et al.
Florian W Adraoui et al.
Treating patients affected by schizophrenia (SZ) remains highly challenging for drug developers. While available antipsychotics mostly reduce positive symptoms, their effects on cognitive and social deficits as well as their underlying path...
Substance P/Neurokinin-1 receptor signaling exhibits sex-specific regulation of inhibitory transmission in the central amygdala [0.03%]
P物质/神经激肽-1受体信号通过性别特异性调节中央杏仁核的抑制性突触传递
Laureta Gashi,Jana Lubec,Bibi Husna Daneyshar et al.
Laureta Gashi et al.
Chronic Morphine Differentially Impacts Glutamatergic Synaptic Plasticity in the Ventral Tegmental Area of Adult versus Adolescent Mice [0.03%]
慢性吗啡对成年小鼠与青春期小鼠中脑腹侧被盖区谷氨酸能可塑性的影响不同
Jeffrey G Edwards,Isaac Ostlund,Michael Von Gunten
Jeffrey G Edwards
Opioids mediate the majority of drug overdose-related deaths in the United States. Opioid-induces addictive behaviors in part via manipulation of excitatory synaptic plasticity of ventral tegmental area (VTA) dopamine cells by targeting pre...