Ciprofloxacin exposure impairs neurogenesis and E/I balance in human cortical organoids [0.03%]
环丙沙星暴露损害人脑类器官神经发生和兴奋/抑制平衡
Haxiaoyu Liu,Linhong Jiang,Qian Bu et al.
Haxiaoyu Liu et al.
Ciprofloxacin (CPFX) is a widely used broad-spectrum fluoroquinolone antibiotic. Although its neurotoxic potential in the mature brain has been recognized, its impact on the developing human nervous system remains largely unexplored. Given ...
Acute ethanol inhibits asynchronous glutamate release from mouse basolateral amygdala synapses [0.03%]
急性乙醇抑制小鼠基底外侧杏仁核突触异步谷氨酸释放
Brian P Parrish,Brian A McCool
Brian P Parrish
Acute ethanol modulates an incredibly diverse number of neurotransmitter receptors and intracellular pathways. Presynaptic modulation by acute ethanol has been identified at some GABAergic synapses; but descriptions of acute ethanol regulat...
Agomelatine alleviates depressive-like behaviors in mice by promoting mitophagy in parvalbumin-expressing neurons of the hippocampal ventral dentate gyrus [0.03%]
阿戈美拉汀通过促进海马腹侧齿状回表达钙结合蛋白(parvalbumin)神经元的线粒体自噬来缓解小鼠抑郁样行为
Suhong Ye,Qiaolu Xu,Ling Bao et al.
Suhong Ye et al.
Background: Major depressive disorder (MDD) is highly prevalent, but some patients are refractory to conventional treatments. Mitochondrial dysfunction, impaired mitophagy, and parvalbumin (PV)-expressing hippocampal neur...
The impact of prebiotic supplementation in a triple-hit rat model of schizophrenia [0.03%]
益生元补充对精神分裂症三重打击大鼠模型的影响
Szonja B Plesz,Kálmán F Szűcs,Bence Ágg et al.
Szonja B Plesz et al.
Schizophrenia is associated with cognitive deficits and higher stress sensitivity, potentially related to gut-brain axis disturbances, partially due to dysbiosis. To ascertain this phenomenon, we aimed to evaluate these behavioral phenotype...
Novel mechanism of hypidone hydrochloride (YL-0919) in Parkinson's disease: inhibiting neuronal ferroptosis by targeting the Sigma1R-PI3K-AKT-ACSL4 axis [0.03%]
盐酸氢达肝癸钠（YL-0919）治疗帕金森病的新机制：靶向Sigma1R-PI3K-AKT-ACSL4轴抑制神经元铁死亡
Mengying Huang,Yanmin Lyu,Jixiang Sun et al.
Mengying Huang et al.
Increasing evidence suggests antidepressants possess neuroprotective and anti-inflammatory properties. Hypidone hydrochloride (YL-0919), a novel antidepressant with rapid antidepressant effects currently in Phase II clinical trials, exhibit...
A bioluminescent ratiometric sensor for the measurement of extracellular ATP concentration in inflammation and cancer [0.03%]
一种生物发光比值传感器用于测定炎症和癌症中的细胞外ATP浓度
Mario Tarantini,Simonetta Falzoni,Marcello Carotti et al.
Mario Tarantini et al.
ATP is not only the key intracellular energy currency but also a ubiquitous extracellular messenger. Large increases in its extracellular concentration occur at sites of infection and inflammation, in the tumor microenvironment and virtuall...
P2X7 receptor or TNAP genetic blockade prevents the reduction of neuronal CTCF detected in tauopathy [0.03%]
P2X7受体或TNAP基因敲除可阻止tau病中神经元CTCF减少的现象
Paloma Aivar,Álvaro Sebastián-Serrano,África Vincelle-Nieto et al.
Paloma Aivar et al.
Intraneuronal aggregates assembled by hyperphosphorylated Tau protein are a common feature of a neurodegenerative disease family, namely Tauopathies. Recent studies have revealed that the ionotropic purinergic receptor P2X7 (P2X7R) and the ...
N,N-dimethyltryptamine elicits antidepressant and anxiolytic effects in helpless mice: a comparative study with S-ketamine [0.03%]
N,N-二甲基色胺与S-氯胺酮在无助小鼠模型中诱导抗抑郁和抗焦虑作用的比较研究
Anne Nathalia de Sousa-Silva,Clarissa de Almeida Moura,Carina Ioná de Oliveira Torres et al.
Anne Nathalia de Sousa-Silva et al.
N,N-dimethyltryptamine (DMT) is an naturally occurring indoleamine with hallucinogenic and antidepressant effects in humans. Here, we compared the effects of DMT and S-ketamine, a fast-acting antidepressant, in helpless mice. To induce help...
Comparative Study
Neuropharmacology. 2026 Jul 1:292:110947. DOI:10.1016/j.neuropharm.2026.110947 2026
Protective effects of adenosine A2B receptor antagonism in a cuprizone-induced demyelination model [0.03%]
腺苷A2B受体拮抗在杯rizone诱导的脱髓鞘模型中的保护作用
Federica Cherchi,Martina Venturini,Lucia Frulloni et al.
Federica Cherchi et al.
Demyelinating diseases are characterized by the progressive loss of myelin in the central nervous system (CNS). Myelin protection can be achieved by fostering the differentiation of oligodendrocyte progenitor cells to mature oligodendrocyte...
Acute and persistent sex-dependent disruptions of sleep-wake architecture induced by fentanyl self-administration in mice [0.03%]
吗啡类止痛药引发的小鼠睡眠结构性别依赖性紊乱现象及其神经机制研究
Tara C Delorme,Samara J Vilca,Ryan W Logan
Tara C Delorme
Chronic opioid use is associated with profound sleep disturbances that may contribute to relapse in opioid use disorder (OUD). However, how opioid self-administration and abstinence alter sleep architecture in a sex-dependent manner remains...