Sevoflurane-induced neurotoxicity in neonatal mice is driven by microglial ferroptosis via MSTRG.7388-dependent NCOA4/STING axis [0.03%]
异丙酚诱导的小鼠神经毒性通过MSTRG.7388依赖性的NCOA4/STING轴促进小胶质细胞铁死亡所致
Qi Zhang,Jiahui Ma,Yi Gao et al.
Qi Zhang et al.
Preclinical investigations have indicated that recurrent sevoflurane exposure induces long-term cognitive deficits in neonatal mice while the effects of inhalational anesthetics on children remain ambiguous. In the current study, Our compre...
IL-1 receptor antagonist attenuates inflammatory injury and improves structural and functional outcomes in the fetal somatosensory cortex after TLR-4 mediated inflammation [0.03%]
白细胞介素1受体拮抗剂可减轻 toll 样受体 4 诱导的胎儿躯体感觉皮质炎症损伤并改善结构和功能预后
Sharmony B Kelly,Steven X Cho,Valerie Zahra et al.
Sharmony B Kelly et al.
Perinatal inflammation, often caused by bacterial infection, is strongly linked with lifelong disability. We tested the hypothesis that IL-1 is a key mediator of inflammatory injury and evaluated whether systemic administration of IL-1 rece...
Deferoxamine attenuates bone cancer pain via modulation of the RIG-I/CCL5 signaling pathway in rats [0.03%]
去铁敏通过调节RIG-I/CCL5信号通路缓解骨癌痛的作用及机制研究在大鼠中的作用及机制研究
Li-Hua Hang,Jia-Jun Ju,Min He et al.
Li-Hua Hang et al.
Bone cancer pain (BCP) severely compromises the quality of life, and its molecular mechanisms are not fully understood. Increasing evidence implicates spinal iron overload in pain-related neuroinflammation, with the chemokine CCL5 acting as...
P2X receptors in immune cells: key regulators of inflammation and immune function [0.03%]
免疫细胞中的P2X受体：炎症和免疫功能的关键调节因素
Elena Adinolfi,Simonetta Falzoni,Federica Fortuna et al.
Elena Adinolfi et al.
P2X receptors are a family of ATP-gated ion channels comprising seven subtypes (P2X1-P2X7). These receptors mediate rapid cation fluxes and downstream signaling events that regulate inflammation, synaptic transmission, and cell death. P2X r...
Targeting the purinergic P2X7 receptor in epilepsy: Cell types matter [0.03%]
癫痫中的P2X7受体靶向治疗：细胞类型有所不同
Tobias Engel,Valentina Salari,Meng-Juan Sun et al.
Tobias Engel et al.
Epilepsy affects up to 70 million people worldwide, making it one of the most prevalent chronic neurological disorders and a major burden on healthcare systems. Although more than 30 anti-seizure medications (ASMs) are currently in clinical...
Endogenous TRPV1 agonist OLDA prevents mu-opioid receptor desensitization and preserves analgesia in sensitized nociceptive circuits [0.03%]
内源性TRPV1激动剂OLDA可防止μ-阿片受体脱敏并可在敏化伤害感受环路中保留镇痛作用
Mario Heles,Daniel Vasconcelos,Jiri Palecek
Mario Heles
Opioid analgesics acting primarily through the μ-opioid receptor (MOR) are profoundly limited by receptor desensitization, tolerance and opioid-induced hyperalgesia. Recent work has identified functional crosstalk between MOR and the trans...
Adam L Halberstadt,Jared W Young
Adam L Halberstadt
Corrigendum to "Chronic morphine differentially impacts glutamatergic synaptic plasticity in the ventral tegmental area of adult versus adolescent mice" [Neuropharmacology (2026) DOI: 10.1016/j.neuropharm.2026.110925] [0.03%]
关于“慢性吗啡对成年小鼠与青少年小鼠腹侧被盖区谷氨酸能突触可塑性不同影响”的勘误[神经药理学（2026）DOI: 10.1016/j.neuropharm.2026.110925]
Jeffrey G Edwards,Isaac Ostlund,Michael Von Gunten
Jeffrey G Edwards
Published Erratum
Neuropharmacology. 2026 Aug 1:293:110966. DOI:10.1016/j.neuropharm.2026.110966 2026
Marco Niello,Predrag Kalaba,Anita Cybulska-Klosowicz et al.
Marco Niello et al.
Psychostimulants act on monoamine systems including the dopamine transporter (DAT), a key regulator of dopamine reuptake following synaptic release. While these compounds can enhance energy, cognition, and sociability, their clinical utilit...
KBN2201 attenuates Aβ pathology and neuroinflammation while promoting neuroprotective and neurogenesis-related changes in a late-stage 5xFAD mouse model of Alzheimer's disease [0.03%]
KBN2201 抵消5XFAD老年痴呆病鼠模型晚期Aβ病理学和神经炎症，同时促进神经保护和神经发生相关变化
Sun-Young Lee,Jong Chul Kim,Jiseo Song et al.
Sun-Young Lee et al.
Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) accumulation, neuroinflammation, neuronal loss, and cognitive decline. Here, we report that KBN2201, a derivative of 2-hydroxy-4-(trifluoromethyl)benzoic acid, exerts multi-targe...