Repeated administration of the synthetic cannabinoid AKB48 induces serotonergic neuroadaptation in male and female mice: behavioural and immunohistochemical evidence [0.03%]
合成大麻素AKB48重复给药诱导小鼠血清素神经适应性：行为和免疫组织化学证据
Giorgia Corli,Fabrizio De Luca,Sabrine Bilel et al.
Giorgia Corli et al.
Background and purpose: In the last years, Synthetic Cannabinoids (SCBs) have established themselves as one of the largest and most popular groups of Novel Psychoactive Substances (NPS), being frequently detected in biolo...
LSD microdosing in major depressive disorder: results from an open-label trial [0.03%]
micro剂量使用LSD治疗重度抑郁障碍：一项开放性试验结果
Dimitri Daldegan-Bueno,Carina Joy Donegan,Rachael Sumner et al.
Dimitri Daldegan-Bueno et al.
Major depressive disorder (MDD) affects approximately 5 % of the global population. Classic psychedelics have shown promise in treating various mental health disorders. This study evaluated the feasibility and tolerability of an 8-week regi...
Multimodal relationships and multifactorial associations between oral microecological and neurodegenerative diseases [0.03%]
口腔微生态与神经退行性疾病之间的多模态关系及多重因素关联性研究
Yi Zhou,Jiaxuan Li,Di Wang et al.
Yi Zhou et al.
Dysregulation of the oral microbiome can result in inflammation of the oral mucosa and is associated with the development and advancement of numerous local and systemic illnesses, including those triggered by viral infections. The review th...
Hippocampal GPR17 down regulation ameliorates CMS-induced depression-like behaviors in mice [0.03%]
小鼠海马GPR17下调可改善慢性束缚应激诱导的抑郁样行为
Zhi Xie,Bing Fan,Tian Tian Zhi et al.
Zhi Xie et al.
Chronic stress is a significant pathogenic factor that contributes to the onset of depression. GPR17 has anti-inflammatory and anti-oxidative effects, but its role in depression is still unknown. In this study, we examined the role of GPR17...
Microdosing psilocybin and its effect on creativity: Lessons learned from three double-blind placebo controlled longitudinal trials [0.03%]
微量使用裸蓋菇素对创造力的影响：三项双盲安慰剂对照纵向试验的经验教训
Luisa Prochazkova,Josephine Marschall,Michiel van Elk et al.
Luisa Prochazkova et al.
Background: Taking very small doses of psychedelics (LSD, truffles) over an extended period became prevalent in western societies for its alleged cognitive benefit, including enhanced creativity. However, in the absence o...
Glutamatergic Neurons in the Ventral Hippocampal CA1 Participate in the Regulation of Comorbidity of Chronic Pain and Depression [0.03%]
伏隔核谷氨酸能神经元参与慢性疼痛和抑郁共病的调控
Wei Meng,Yihang Lv,Zihan Ren et al.
Wei Meng et al.
Background: Chronic pain and depression are highly comorbid conditions that pose a significant clinical challenge, yet the underlying neural circuitry mechanisms are poorly understood. The ventral hippocampal CA1 (vCA1) h...
Corrigendum to "Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration" [Neuropharmacology 109834 (2023) DOI: 10.1016/j.neuropharm.2023.109834] [0.03%]
补遗：“ Centella asiatica中的马兜铃酰醇在蛋白 L-异天冬氨酰甲基转移酶缺乏引起的神经退行性疾病中的保护作用”[ Neuropharmacology 109834 (2023) DOI: 10.1016/j.neuropharm.2023.109834]
Zicheng Ling,Sirui Zhou,Yancheng Zhou et al.
Zicheng Ling et al.
Published Erratum
Neuropharmacology. 2025 Oct 31:110735. DOI:10.1016/j.neuropharm.2025.110735 2025
Influence of social support on the acquisition of conditioned place aversion induced by chemical stimulation of the dorsal periaqueductal gray matter: a sex-dependent approach [0.03%]
社会支持对脑导水管周围灰质化学刺激所致条件性地方厌恶的影响及性别差异研究
Alvaro Henrique Bernardo de Lima Silva,Pedro Henrique Azevedo de Oliveira,Joice Maria da Cunha et al.
Alvaro Henrique Bernardo de Lima Silva et al.
Social support (SS) provided by conspecifics during an aversive situation can influence the processing of fear and anxiety responses. However, the effect of social support on the aversive response produced by stimulation of the dorsolateral...
Indole-3-acetic acid exerts protective effects on sleep deprivation-induced cognitive impairment [0.03%]
吲哚乙酸对睡眠剥夺致认知障碍的改善作用研究
Jiao Han,Linjuan Zhang,Yixuan Lyu et al.
Jiao Han et al.
The gut microbiota and its metabolites have increasingly been recognized as crucial factors contributing to the cognitive deficits induced by sleep deprivation (SD), a condition characterized by diminished hippocampal neurogenesis. Neverthe...
TREK-1 channel blockade mediates the antidepressant-like effects of hydroxynorketamine [0.03%]
羟基若立醚的抗抑郁作用类似物介导TREK-1通道阻滞的作用
Yingcai Song,Yujie Song,Weijia Du et al.
Yingcai Song et al.
The ketamine metabolite (2R,6R)-hydroxynorketamine [(2R,6R)-HNK] exhibits rapid antidepressant effects without the psychotomimetic or addictive side effects associated with ketamine, making it a promising therapeutic candidate. However, the...