Perinatal Opioid Exposure Alters Alcohol-Driven Reward Behaviors in Adolescent Male & Female Rats [0.03%]
围产期接触阿片类药物会改变青春期大鼠的酒精驱动奖赏行为
Christopher T Searles,Meghan E Vogt,Hannah J Harder et al.
Christopher T Searles et al.
In the U.S., a baby is born with neonatal opioid withdrawal syndrome (NOWS) every fifteen minutes-a rate that has increased sevenfold since 2004. Clinical studies have established intrauterine exposure to addictive drugs as a risk factor fo...
Blockage of the peri-synaptic Schwann cell nicotinic α7 receptor inhibitory drive increases the neuromuscular performance in rats with experimental autoimmune Myasthenia gravis: repurposing dipyridamole usage in myasthenics [0.03%]
面向小鼠周围突触施万细胞烟碱型乙酰胆碱受体α7亚基胆碱能抑制环路的药物干预可改善自身免疫源性重症肌无力的神经肌肉传递功能：潘生丁治疗重症肌无力的新用途探索研究
José Bernardo Noronha-Matos,Carlos Sousa-Soares,Beatriz Alves-Oliveira et al.
José Bernardo Noronha-Matos et al.
Acetylcholine spillover from the neuromuscular synapse triggers an inhibitory drive via the activation of nicotinic α7 receptors (α7nAChRs) on perisynaptic Schwann cells (PSCs). This mechanism involves the outflow of adenosine from PSCs v...
Prelimbic cortex, but not its nucleus reuniens projections, regulates punished alcohol self-administration [0.03%]
前扣带回皮层调控惩罚诱导的酒精摄入行为，而非其核团r受体注射调控
Maya N Bluitt,Wen Liu,Ana C Muñoz et al.
Maya N Bluitt et al.
Alcohol use that persists despite negative consequences is observed in only a minority of those who drink alcohol and is a defining feature of alcohol use disorder (AUD). The neurobiological mechanisms underlying drinking despite negative o...
Identification and validation of Slit3 as a depression biomarker modulating dynorphinergic neurons in the hypothalamic paraventricular nucleus [0.03%]
Slit3的鉴定与验证：作为调节下丘脑室旁核Dynorphin能神经元的抑郁症生物标志物
Yun-Hao Jiang,Cai-Yu Zhai,Jia-Na Ying et al.
Yun-Hao Jiang et al.
Depression is a psychiatric disorder primarily characterized by anhedonia, yet its underlying mechanisms remain incompletely understood. In this study, using a chronic social defeat stress (CSDS) models of male C57BL/6 J mice, we observed i...
Lysosomal TRPML1 activation modulates synaptic transmission and intrinsic neuronal excitability [0.03%]
溶酶体TRPML1激活调控突触传递和固有神经兴奋性
Masood Ahmad Wani,Chloe M Hall,Thomas Mittmann et al.
Masood Ahmad Wani et al.
The calcium channel TRPML1 regulates key functions in lysosomes and has emerged as a promising therapeutic target for lysosomal storage diseases and neurodegenerative diseases. While pharmacologically, TRPML1 activation has been shown to re...
Prenatal alcohol exposure induces circular and linear long non-coding RNAs and protein-coding genes linked to proinflammatory neuroimmune function, promoting nerve injury-induced allodynia following morphine treatment [0.03%]
孕期酒精暴露诱导环状和线性长链非编码RNA及与促炎神经免疫功能相关的蛋白编码基因，促进阿片类药物治疗后的机械痛觉过敏发生发展
Ariana N Pritha,Andrea A Pasmay,Alissa N Jones et al.
Ariana N Pritha et al.
Prenatal alcohol exposure (PAE) exerts lingering effects on neuroimmune function. Based on existing literature on overlapping neuroimmune actions of PAE and opioid pain therapies, here, we examined pain sensitivity (allodynia) in adult male...
The association of the Wnt/β-catenin signaling pathway with Alzheimer's disease [0.03%]
Wnt/β-catenin信号通路与阿尔茨海默病的关系
JiaYing Ma,Yi Liu,Desheng Lu et al.
JiaYing Ma et al.
With the global rise in population aging, the incidence of Alzheimer's disease (AD) continues to increase, posing a substantial burden on individuals, families, and healthcare systems. However, at present, the drugs approved by FDA for trea...
Caffeine Citrate does not reduce brain injury following inflammation-amplified hypoxia ischaemia or hypoxia ischaemia in the Newborn Piglet Model [0.03%]
山梨醇咖啡因不能减轻新生猪缺氧缺血或炎症放大缺氧缺血性脑损伤
George Maple,Christopher Meehan,Ilenia d&#x;Angelo et al.
George Maple et al.
There is a need to develop alternative therapies for neonatal encephalopathy (NE) in term babies. Caffeine citrate exposure saw benefit in preclinical models of hypoxia-ischaemia (HI). We assessed the safety and cytoprotective efficacy of c...
Golexanolone affords sustained improvement of Parkinson's symptoms in rats by reducing microglia activation that restores the glutamate-GABA-dopamine pathway [0.03%]
戈列克安alone通过减少小胶质细胞活化来恢复谷氨酸-γ氨基丁酸-多巴胺通路，从而在大鼠中实现帕金森症状的持续改善
Maria A Pedrosa,Gergana Mincheva,Mar Martinez-Garcia et al.
Maria A Pedrosa et al.
Golexanolone improves motor and non-motor symptoms in the 6-OHDA rat model of Parkinson's disease (PD) and reduces neuroinflammation in the striatum, without inducing dyskinesias. To understand the underlying mechanisms, we hypothesized tha...
Iguratimod Attenuates Diabetic Cognitive Impairment via Suppressing B Cell Activation and CD8+ T Cell Cytotoxicity [0.03%]
艾固拉替莫德通过抑制B细胞活化和CD8+T细胞细胞毒性作用减轻糖尿病认知障碍
Qingsheng Yin,Runtao Su,Xuan Nie et al.
Qingsheng Yin et al.
Diabetes-induced cognitive impairment (DCI) is a common complication in diabetic patients with an unclear pathogenesis, and there are currently no approved therapeutic drugs available. Iguratimod (IGU) is a novel small molecule immunosuppre...