Oxytocin may promote hippocampal neurogenesis in ischemic stroke rats via a pathway related to DNMT1-mediated Wnt3a/β-catenin [0.03%]
oxytocin可能通过DNMT1介导的Wnt3a/β-catenin信号通路促进缺血性脑卒大鼠海马区神经发生
Xiaofan Li,Guang Shi,Wanshu Guo et al.
Xiaofan Li et al.
DNA methylation plays a pivotal role in neuroprotection after ischemic stroke. Oxytocin, a neuropeptide renowned for its involvement anti-inflammatory and antioxidant activities, emerges as a promising candidate for the treatment of stroke....
James P Farmer,James E Mason,Nicholas D Holliday et al.
James P Farmer et al.
Since the initial identification of ligand bias in the late 1990s, the possibility of designing new clinical compounds that preferentially target select signalling pathways has been attractive to drug developers. The potential for maximisin...
Effects of predator odor stress on alcohol-induced conditioned taste aversion and lateral habenula cFos expression in rats [0.03%]
应激性敌害气味对酒精致大鼠条件化味觉厌恶和外侧缰核cFos表达的影响
O R Brunke,S M Bonauto,E M Boshak et al.
O R Brunke et al.
Stress-related disorders and alcohol use disorder (AUD) frequently co-occur, yet the mechanisms linking stress coping styles to alcohol sensitivity remain unclear. Here, we tested whether acute stress exposure alters sensitivity to alcohol'...
Multi-kinase-mediated alterations in Tau phosphorylation, synaptic proteins, and choline metabolism in a human neuronal in vitro model exposed to the elastin-derived hexapeptide VGVAPG [0.03%]
人神经元模型暴露于弹性蛋白衍生的六肽VGVAPG后tau蛋白磷酸化、突触蛋白和胆碱代谢的多激酶介导的变化
Bartosz Skóra,Tomasz Piechowiak,Konrad A Szychowski
Bartosz Skóra
Elastin, a key component of the extracellular matrix (ECM), undergoes degradation during aging, leading to the release of shorter bioactive fragments - among which the VGVAPG hexapeptide exhibits the highest biological activity. Although as...
Melatonin ameliorates copper accumulation-induced cognitive impairment in Wilson disease via activation of the SIRT3/FOXO3α signaling pathway [0.03%]
褪黑素通过激活SIRT3/FOXO3α信号通路改善威尔森病铜蓄积所致的认知障碍
Luyao Wang,Limin Wu,Tingting Wang et al.
Luyao Wang et al.
Wilson disease (WD) was identified as a copper (Cu)-overload disorder characterized by disrupted Cu metabolism that caused multi-system damage. Accumulating clinical evidence indicated that cognitive deficits were present in patients with W...
Purinergic signaling in Stroke and Multiple Sclerosis: Prospects for therapies [0.03%]
嘌呤能信号在中风和多发性硬化症中的作用：治疗方法的前景
Abraham Cisneros-Mejorado,Antònia Colom-Casasnovas,Alberto Pérez-Samartín et al.
Abraham Cisneros-Mejorado et al.
Stroke and multiple sclerosis involve oxygen and nutrient deprivation in the brain as well as inflammation, all of which lead to the release of glutamate and ATP. These compounds can cause excitotoxicity, contributing to neuronal and glial ...
Increased activity of GSK3β in NAc D2-MSNs contributes to methamphetamine-induced conditioned place prefernence [0.03%]
NAcD2-MSNs中GSK3β活性增强参与了甲基苯丙胺条件位置偏爱效应
Jincen Liu,Yue Feng,Yudian Ye et al.
Jincen Liu et al.
Glycogen synthase kinase 3β (GSK3β) in the nucleus accumbens (NAc) is implicated in drug addiction, but its specific role in methamphetamine (METH)-induced conditioned place preference (CPP), including the critical phase and the involved ...
Emerging role of N6-methyladenosine (m6A) epitranscriptomic changes in adult anxiety after adolescent alcohol exposure [0.03%]
青春期酒精暴露对成人焦虑中N6-甲基腺苷(m6A)表转录组变化的新兴作用
Emir Malovic,Jamuna Tandukar,Huaibo Zhang et al.
Emir Malovic et al.
Adolescent intermittent ethanol (AIE) exposure affects multiple brain regions by producing long-lasting effects on epigenetic mechanisms and behavioral phenotypes later in life. Recently, it has been shown that epigenetic switches can contr...
Cyclooxygenase 2 (COX-2) expression is elevated in prefrontal cortex neurons, not microglia, following methamphetamine self-administration in male and female rats [0.03%]
雄性和雌性大鼠自我服用methamphetamine后，环氧化酶2（COX-2）在前额皮质神经元中的表达升高而不是小胶质细胞中的表达升高
Amanda M Acuña,Rebecca Whittington,Emma Peacock et al.
Amanda M Acuña et al.
Methamphetamine (METH) use produces lasting elevations in peripheral and central inflammation that correspond to cognitive and behavioral deficits, which may contribute to the likelihood of relapse. Though a great deal of research over the ...
Fluoxetine Modulates Both Endocannabinoid and Lysophosphatidic Acid Pathways in a Region-Specific Manner During Alcohol Withdrawal in Male Rats [0.03%]
氟西汀以区域特异性方式调节酒精戒断大鼠内源大麻素和溶血磷脂酸途径
Adriana Castro-Zavala,Kirstin Boonen,Laura Sánchez-Marín et al.
Adriana Castro-Zavala et al.
Anxiety is a major symptom associated with alcohol withdrawal and a major factor increasing the risk of relapse. Although fluoxetine, a selective serotonin reuptake inhibitor, is used to alleviate these symptoms, its effects on brain lipid ...