Targeting treatment-resistant social anxiety with sitagliptin: effects on social fear and comorbid depressive-like behavior in a preclinical model [0.03%]
西格列汀靶向治疗难治性社交焦虑：对临床前模型中社交恐惧和共病抑郁样行为的影响
Iulia Zoicas,Johannes Kornhuber
Iulia Zoicas
Social anxiety disorder (SAD) is often complicated by comorbid depression and resistance to standard treatments, yet therapeutic strategies that effectively address both core and comorbid symptoms remain limited. We previously demonstrated ...
Activation of 5-HT4 Receptors Reverses Stress-induced Dopamine System Dysregulation [0.03%]
5-HT4受体激活逆转应激诱导的多巴胺系统失调
Olivia J Yang,Stephanie M Perez,Daniel J Lodge
Olivia J Yang
Stress can profoundly impact brain function, particularly in circuits regulating dopamine transmission. Increased mesolimbic dopamine activity is a well-documented consequence of stress exposure, contributing to maladaptive behavioral and c...
HCN channel inhibitor ZD7288 in the lateral septum attenuates methamphetamine-induced behavior sensitization and relapse [0.03%]
侧隔室HCN通道抑制剂ZD7288削弱甲基苯丙胺引起的寻死行为敏感性及复吸
Shishi Lai,Wenpei Zhang,Cailing Wang et al.
Shishi Lai et al.
Drug addiction involves dysregulation in limbic circuits, with the lateral septum (LS) playing a critical role in regulating drug reward and behavioral sensitization. Although chronic methamphetamine (METH) upregulates hyperpolarization-act...
Enteric gliosis induced by TRPV4 alleviates intestinal excessive-motility through Ca2+ signaling [0.03%]
瞬时受体电位锚定通道V4诱导肠胶质细胞活化减轻肠过度活动症的机制研究
Qianshan Tan,Teming Li,Huichao Xie et al.
Qianshan Tan et al.
Background: Gastrointestinal (GI) dysmotility is a fundamental clinical issue in multiple diseases such as IBS, and there is a critical requirement for drugs to precisely modulate excessive GI motility. Enteric glial cell...
Age-dependent transcriptomic effects of morphine in the frontal cortex of female mice [0.03%]
吗啡在雌性小鼠前额叶皮层中的年龄依赖性转录组效应
Jarvis Savage,Anupama Rai,Jonathan Lee et al.
Jarvis Savage et al.
Increasing lifespans make health problems in the elderly such as opioid misuse a more prominent concern. Understanding the effects that opioids may have on the aged brain can help us address age-related concerns of opioid exposure. This stu...
Downregulation of SNORD20 promotes ferroptosis in corpus cavernosum smooth muscle cells from diabetic rats through inducing the mitochondrial dysfunction [0.03%]
SNORD20下调通过诱导线粒体功能障碍促进糖尿病大鼠阴茎海绵体平滑肌细胞铁死亡
Yiyu Qin,Wenjie Huang,Yang Zhou et al.
Yiyu Qin et al.
Erectile dysfunction (ED) disturbs the life of elderly men, and ferroptosis may be associated with the progression of ED. Small nucleolar RNAs (snoRNAs, 60-300 nucleotides) are non-coding regulatory RNAs mainly located in cell nucleolus, an...
Cftr Nominates a Novel Therapeutic Target for Alzheimer's Disease: Evidence from Integrative Omics and In Vitro Validation [0.03%]
CTFR作为阿尔茨海默病治疗新靶点的发现：整合组学和体外验证提供的证据
Hao-Ran Li,Jun-Zhuo Shi,Meng-Jie Zhang et al.
Hao-Ran Li et al.
Alzheimer's disease (AD), among the most prevalent neurodegenerative disorders, poses substantial challenges for therapeutic development due to its complex pathophysiology, necessitating novel treatment strategies. This study applied an int...
Osthole Ameliorates Cognitive Impairment in Ovariectomized Rats via Estrogen-Mediated Enhancement of Cholinergic Function and Regulation of Neurotransmitter Homeostasis [0.03%]
欧香豆素通过雌激素介导的胆碱能功能增强和神经递质稳态调节来改善卵巢切除大鼠的认知障碍
Yanman Liu,Jimei Zhang,Wenjuan Li et al.
Yanman Liu et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive dysfunction that is closely associated with cholinergic system damage. Estrogen deficiency is a well-established risk factor for AD in women. Os...
Assessment of the therapeutic effect of IGS2.7, a CK1δ protein kinase inhibitor, in combination with riluzole for the treatment of ALS-associated TDP-43 proteinopathy [0.03%]
评估IGS2.7（一种CK1δ蛋白激酶抑制剂）与利鲁唑联用治疗ALS相关TDP-43蛋白病的疗效
Marta Gomez-Almeria,Loreto Martinez-Gonzalez,Ana Teresa Matos et al.
Marta Gomez-Almeria et al.
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease for which no effective treatments currently exist. The FDA and EMA have approved only riluzole, a drug that modestly extends patient survival by 3-18 months. In ...
Evaluating Tocilizumab in Ischemic Stroke: Findings from the SPAN Multicenter Trial [0.03%]
托珠单抗治疗缺血性卒中的疗效研究——SPAN多中心试验结果
Anjali Chauhan,Eunyoung Angela Lee,Rakesh B Patel et al.
Anjali Chauhan et al.
Inflammation, particularly mediated through interleukin-6 (IL-6) signaling, plays a critical role in stroke pathophysiology. High levels of IL-6 are associated with poor outcomes in stroke patients. Therapeutic inhibition of IL-6 signaling ...